Protein Alignment Est-6 and CES1

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 166/563 - (29%)
• Similarity: 241/563 - (42%)
• Gaps: 136/563 - (24%)

  Fly    13 SCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGDLRFEAPE 67
            |..|.|..:|    |.:|....||:.|:    :.|.|          .||:|:||.|.|||..|:
Human    14 SAAWAGHPSS----PPVVDTVHGKVLGK----FVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQ 70

  Fly    68 PYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE--------------EDCLTVSVYKPKN-SK 117
            | .:.||.:.:||..|..|.|    .|.|.:|:.|              ||||.:::|.|.: :|
Human    71 P-AEPWSFVKNATSYPPMCTQ----DPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTK 130

  Fly   118 RNSFPVVAHIHGGAFMFGAA-WQNG-----HENVMREGKFILVKISYRLGPLGFVSTGDRDLPGN 176
            :|..||:..||||..|.||| ..:|     ||||      ::|.|.||||..||.||||....||
Human   131 KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENV------VVVTIQYRLGIWGFFSTGDEHSRGN 189

  Fly   177 YGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDP 241
            :|..||..||:|::.|||||||.|.:|.:.|.||||.||.:.:|......|...|.|.||.||..
Human   190 WGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTS 254

  Fly   242 WVIQKG-ARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV--TAVRKFLIFSYVPFAPFSPV 303
            .:::|| .:..|.::....||::. .|..:..||:.|...||:  |...|||..........|..
Human   255 VLVKKGDVKPLAEQIAITAGCKTT-TSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQP 318

  Fly   304 LEPSDAPDAIITQDPRDVIKSGKFGQVPWAV----------------SYVTEDG----------- 341
            |..:.....::.:.|.::.....|..||:.|                ||...:|
Human   319 LLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLL 383

  Fly   342 --GYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIE 404
              .|....:.||     :|.:..|:      ||....||..|||       :..:.|.:..|.:.
Human   384 WKSYPLVCIAKE-----LIPEATEK------YLGGTDDTVKKKD-------LFLDLIADVMFGVP 430

  Fly   405 SYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYD-NPAEKGIAQVLANRTDYDFGTV--- 465
            |.         |:.:|        ||..| :|.|.|.:. .|:..         :|....||
Human   431 SV---------IVARN--------HRDAG-APTYMYEFQYRPSFS---------SDMKPKTVIGD 468

  Fly   466 HGDDYFLIF-ENFVRDVEMRPDEQI-ISRNFINMLADFASSDN 506
            |||:.|.:| ..|::  |...:|:| :|:..:...|:||.:.|
Human   469 HGDELFSVFGAPFLK--EGASEEEIRLSKMVMKFWANFARNGN 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	161/547 (29%)
		Aes	<110..>243	CDD:223730	63/139 (45%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	161/548 (29%)
		Aes	<122..>240	CDD:223730	56/123 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840