DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	245/532 - (46%)	Gaps:	75/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSY----------YSYESIPYAEPPT 58
            |..||:::|..:    :..|:..|:     :...||:..||:          :::..||:|:||.
Mouse    13 VACGLLLLLQHV----HGQDSASPI-----RNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPV 68

  Fly    59 GDLRF---EAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVG--------EEDCLTVSVYK 112
            |.|||   |.|||    ||.:.|.|..|..|||.|.......|.:.        .||||.:::|.
Mouse    69 GLLRFAPPEDPEP----WSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYT 129

  Fly   113 PKNSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGN 176
            |.:::..| .||:..||||..:.|:|..|....:....:.::|.|.||||.|||.||||:...||
Mouse   130 PTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHARGN 194

  Fly   177 YGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDP 241
            :|..||..||:|:::|||.|||....|.:.|.||||.||...:|......|...|...||.||.|
Mouse   195 WGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLP 259

  Fly   242 WVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEP 306
            .:|...:......:....||| |.||.:|..||::|...|::...:.|.:...|....|.|
Mouse   260 DLISDTSEVVYKTVANLSGCE-ATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLP---- 319

  Fly   307 SDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGI--VIDDLNERWLELA 369
                     :.|::::.|..|..||..:...|::.|:...:.:     |:  :|.::..   |..
Mouse   320 ---------KHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFM-----GLDHIIKNITR---ETL 367

  Fly   370 PYLLFYRDTKTKKDM-DDYSRKIKQEYIGNQRFDIESYSELQRLFTDIL--FKNSTQESLDLHRK 431
            |.:|  ::|..:..: .:.|..:.:||:|    |.|....||..|.::|  |..........|.:
Mouse   368 PAVL--KNTAARMMLPPECSHLLVEEYMG----DTEDPETLQAQFREMLGDFMFVIPALQVAHFQ 426

  Fly   432 YGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRD--VEMRPDEQIISRNF 494
            ..::|.|.|.:.: ....|..|..:....|    ||||...:|.:::.|  :::..:|:::.|..
Mouse   427 RSQAPVYFYEFQH-LSSFIKHVRPSHVKAD----HGDDVAFVFGSYLWDMNLDLTEEEELLKRMM 486

  Fly   495 INMLADFASSDN 506
            :...|:||.:.|
Mouse   487 MKYWANFARNGN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	145/507 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/133 (41%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	146/511 (29%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	43/102 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850