DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and nlgn3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_012823589.1	Gene:	nlgn3 / 100329188	XenbaseID:	XB-GENE-977261	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	152/563 - (26%)
Similarity:	224/563 - (39%)	Gaps:	133/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GLGLIIV---LS-CLW--------LGSNA---SDTDDPLLVQLPQGKLRG-------RDNGSYYS 47
            |:||.:.   || .||        |.|:|   |.|     |....|||||       ...|....
Frog     3 GVGLKVAPRKLSLVLWVLSVTSRVLSSHAQVYSQT-----VNTHYGKLRGTRVPLPSEILGPVDQ 62

  Fly    48 YESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ-------------WDQFTPGANKL 99
            |..:|||.||.|:.||..||| ...||.|.:||.....|.|             |  ||...:.:
Frog    63 YLGVPYAAPPVGEKRFLPPEP-PPSWSGIRNATHFSPVCPQNIQNAVPDIMMPVW--FTSNLDTV 124

  Fly   100 VG-----EEDCLTVSVYKP-------------KNSKR---------------------------- 118
            .|     .||||.:::|.|             |.:|:
Frog   125 TGYLQEQSEDCLYLNIYVPTEDVKRISKECVRKPNKKICRKGGPSAKKQGEELSDNDEDEEGDIR 189

  Fly   119 --NSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKD 181
              .:.||:.:||||::|.|:........:...|..:::.::||:|.|||:||||:...|||||.|
Frog   190 DTGAKPVMVYIHGGSYMEGSGNMIDGSVLASYGNVVVITLNYRVGVLGFLSTGDQAAKGNYGLLD 254

  Fly   182 QRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQK 246
            |..||:|:.:|:|.|||:|..:.:.|...|.:.|.|..|......|.:.|...||:||..|.:..
Frog   255 QIQALRWVSENVAFFGGDPHRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNY 319

  Fly   247 GARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVP---FAPFSPVLEPSD 308
            ........|...||| :..|:..:..||:.|.|.|||..       ...|   ...|.||::...
Frog   320 QPVKYTRLLAEKVGC-NVLDTVDMVDCLRQKSAKELVEQ-------DIQPARYHVAFGPVIDGDV 376

  Fly   309 APDAIITQDPRDVIKSGKFGQVPWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLEL 368
            .||     ||..:::.|:|      ::|     |.:..|......:.:.:.|:...|.:......
Frog   377 IPD-----DPEILMEQGEF------LNYDIMLGVNQGEGLKFVENVVDAEDGVSGSDFDYSVSNF 430

  Fly   369 APYLLFYRDTKTKKDMDDYSRKIKQEYIG-NQRFDIESYSE-LQRLFTDILFKNSTQESLDLHRK 431
            ...|..|.:.|     |.....||..|.. ..|.:.|:..: |..||||..:...:..:.|||.:
Frog   431 VDNLYGYPEGK-----DTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHAR 490

  Fly   432 YGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
            || ||.|.|.:.:..:..:....|:       ..|||:...:|
Frog   491 YG-SPTYFYAFYHHCQSLMKPAWAD-------AAHGDEVPYVF 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	140/524 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	50/175 (29%)
nlgn3	XP_012823589.1	COesterase	31..618	CDD:278561	143/535 (27%)
nlgn3	XP_012823589.1	Aes	<195..>302	CDD:223730	41/106 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910