DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and ces3.1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001120019.1	Gene:	ces3.1 / 100144981	XenbaseID:	XB-GENE-6467140	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	156/556 - (28%)
Similarity:	244/556 - (43%)	Gaps:	123/556 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGS------YYSYESIPYAEPPTGDLRFEAPE 67
            :::|.|..|....::...|||: ...|:|.|:..|:      .:.:..:|:|:||.|.||||||:
Frog     7 VLLLCCATLEIYGTEDARPLLM-TKYGQLLGKTVGAKETDRLVHVFMGVPFAKPPIGPLRFEAPQ 70

  Fly    68 PYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE----------------EDCLTVSVYKPKNS 116
            | .:.||.:.:||.....|||        :|.|.|                ||||.::|:.|.:.
Frog    71 P-PEPWSSVREATAPSPMCLQ--------DKEVMELLADFFKAKFDFSRVSEDCLYLNVFTPADK 126

  Fly   117 KRN-SFPVVAHIH------GGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLP 174
            ..| ..||:..||      |||.||..:..:.:|||      ::|.|.||||.:||:||||:::.
Frog   127 GENPGLPVMVFIHGGGLAIGGASMFEGSALSAYENV------VVVSIQYRLGIMGFLSTGDKEVR 185

  Fly   175 GNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNAL 239
            ||:|..||..||:|::.||..|||:||:|.:.|.||||.||...:|......|...|.:.||.|:
Frog   186 GNFGFLDQVAALQWVRDNIKDFGGDPQSVTIFGESAGGLSVSALVLSPLSEGLFHRAIAESGVAI 250

  Fly   240 DPWVIQKGARG--RAFELGRNVGCESAEDSTSLKKCLKSKPASEL--VTAVRKFLIFSYVPFAPF 300
            .|.:.......  ...::..||...|..|   |..|||:|...|:  :||..:::||..|....|
Frog   251 LPGLTASKTEEILPLLDMVINVSSCSVSD---LVGCLKNKTEDEIIEITAAMRYVIFPAVVDGVF 312

  Fly   301 SPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERW 365
            .|  :|::           :::.:.:...||:.:       |.|                 |..:
Frog   313 LP--KPAE-----------EILAAKESHPVPFLI-------GIN-----------------NHEF 340

  Fly   366 LELAPYLL---FYRDTKTKKD-------------MDDYSRKIKQEYIGNQRFDIESYSELQRLFT 414
            ..:.|..|   .||:...|||             :......|.:||.|:.....|..:....|..
Frog   341 GSMLPVTLNITGYREGMEKKDIQAILGALPLLNTVSSVIPFIMEEYFGDTNDPKELRNNFLDLAG 405

  Fly   415 DILFKNSTQESLDLHRKYGKSPAYAYVYDN-PAEKGIAQVLANRTDYDFGTV-HGDD-YFLIFEN 476
            ||:|......:...||..| .|.|.|.:.: |:       |...:..||... |||: ||:....
Frog   406 DIIFVIPALRTAKYHRDSG-FPVYFYEFQHRPS-------LYADSKEDFVKADHGDELYFVGGGP 462

  Fly   477 FVRDVEM-----RPDEQIISRNFINMLADFASSDNG 507
            |:::..:     ..:|:|:|:..:...|:||.  ||
Frog   463 FLKNGILFKSNGTEEEKILSKTIMKYWANFAR--NG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	151/536 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	57/139 (41%)
ces3.1	NP_001120019.1	COesterase	25..536	CDD:365897	153/538 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010