DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and nlgn1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_017213657.1	Gene:	nlgn1 / 100002610	ZFINID:	ZDB-GENE-090918-1	Length:	867	Species:	Danio rerio

Alignment Length:	561	Identity:	149/561 - (26%)
Similarity:	227/561 - (40%)	Gaps:	131/561 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDN-------GSYYSYESIPYAEPPTGDL 61
            |||.|...|:    .|...|..|| :|....||:||...       |....:..:|||.||||:.
Zfish    35 VGLALHAQLA----ASEKLDETDP-IVTTTYGKVRGFKKELNNEILGPVIQFLGVPYAAPPTGER 94

  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQ--------------WDQFTPGANKLVG-----EEDCLT 107
            ||:.||| ...||:|.:||:....|.|              |  ||.....:..     .||||.
Zfish    95 RFQPPEP-PISWSEIRNATQFAPVCPQTLLEGRLPDVMLPVW--FTNSIEVVSSYVQDQSEDCLF 156

  Fly   108 VSVYKPK-------------------------NSKRNS-------------------FPVVAHIH 128
            :::|.|.                         :.|:|.                   .||:..:|
Zfish   157 LNIYVPTEDVKRISKECARKPGKKICRKGGPLSKKQNDDLADNDGAEDEDIRESGSPKPVMVFVH 221

  Fly   129 GGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNI 193
            ||::|.|.........:...|..|::.::||||.|||:||||:...|||||.|...||:|..:||
Zfish   222 GGSYMEGTGNMFDGSILASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENI 286

  Fly   194 ASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQ----------LARAAFSFSGNALDPWVIQKGA 248
            |.|||:|..:.:.|..||.:.|:|..| ..:.:          |.:.|.:.||.||..|.:....
Zfish   287 AFFGGDPLRITVFGSGAGASCVNLLTL-SHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQP 350

  Fly   249 RGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV---TAVRKFLIFSYVPFAPFSPVLEPSDAP 310
            ...|..|.:.||| :.:|:..:.:||:.|...|||   ....::.|       .|.||::....|
Zfish   351 AKYARMLAKKVGC-NLKDTVEMVECLQKKHYKELVEQDIQPARYHI-------AFGPVIDGDVIP 407

  Fly   311 DAIITQDPRDVIKSGKFGQVPWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAP 370
            |     ||:.:::.|:|      ::|     |.:..|.....|:.:.::|:..:|.:........
Zfish   408 D-----DPQILMEQGEF------LNYDIMLGVNQGEGLKFVELIVDNENGVQANDFDYAVSSFVD 461

  Fly   371 YLLFYRDTKTKKDMDDYSRKIKQEYIG-NQRFDIESYSE-LQRLFTDILFKNSTQESLDLHRKYG 433
            .|..|.:.|     |.....||..|.. ..|.:.|:..: |..||||..:......:.|||..:|
Zfish   462 DLYGYPEGK-----DILRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSSFG 521

  Fly   434 KSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
             ||.|.|.:.:..:.......|:       ..|||:...:|
Zfish   522 -SPTYFYAFYHHCQTEQVPPWAD-------AAHGDEIPYVF 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	140/536 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/186 (28%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:306613	142/539 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740