DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and nlgn2b

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001159808.1	Gene:	nlgn2b / 100002407	ZFINID:	ZDB-GENE-090918-3	Length:	860	Species:	Danio rerio

Alignment Length:	547	Identity:	147/547 - (26%)
Similarity:	218/547 - (39%)	Gaps:	134/547 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVL-SCLWLGSNASDTDDPLLVQLPQGKLRG----RDN---GSYYSYESIPYAEPPTGD 60
            :||.|.:.| ||  ..::.:....| :|....|||||    .:|   |....|..:|||.||.|:
Zfish    30 LGLALRLALSSC--QRADLTTAKHP-MVTTGYGKLRGVRKELNNEILGPVEQYLGVPYATPPVGE 91

  Fly    61 LRFEAPEPYKQKWSDIFDATKTPVACLQ-------------WDQFTPGANKLVG-----EEDCLT 107
            .||:.||. ...|.:|.:||:....|.|             |  ||...:....     .||||.
Zfish    92 RRFQPPEA-PGSWQEIRNATQFAPVCPQNIHGVLPEIMLPVW--FTDNLDAAAAYVQNQSEDCLY 153

  Fly   108 VSVYKPKNS---------------------KRNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKF 151
            ::||.|...                     .|...||:..||||:||.|.........:...|..
Zfish   154 LNVYVPTEDGPLTKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSFMEGTGNMFDASVLAAYGNV 218

  Fly   152 ILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVH 216
            |:|.::||||.|||:|:||:...|||||.||..||:|:.:||..|||:|:.:.:.|..||.:.|:
Zfish   219 IVVTMNYRLGVLGFLSSGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVN 283

  Fly   217 LQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASE 281
            |.:|......|.:.|.:.||:|:..|.:..........|.:.||| |..|:..|..||:.|...|
Zfish   284 LLILSHHSEGLFQRAIAQSGSAISSWSVNYRPLMYTKILAKKVGC-SYSDTADLVDCLRRKSYRE 347

  Fly   282 LV---TAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGY 343
            ||   ....::.|       .|.||::....||     ||..:::.|:|      ::|
Zfish   348 LVDQDVQPARYHI-------AFGPVVDGDVVPD-----DPEILMQQGEF------LNY------- 387

  Fly   344 NAALLLKERKSGI--VIDDLNERWLELAPY----------LLFYRDTK--------------TKK 382
             ..||...:..|:  |.|:..|..:..|.:          |..|.:.|              ..:
Zfish   388 -DILLGVNQGEGLKFVDDNEGEEGISAASFDYTISNFVDNLYGYPEGKDILRETIKFMYTDWADR 451

  Fly   383 DMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAE 447
            |..|..||                 .|..||||..:......:..||.:: :||.|.|.:.:..:
Zfish   452 DNGDMRRK-----------------TLLALFTDHQWVAPAVATAKLHAEF-QSPVYFYTFHHHCQ 498

  Fly   448 KGIAQVLANRTDYDFGTVHGDDYFLIF 474
            .......|:       ..|||:...:|
Zfish   499 TEARPEWAD-------AAHGDEIPYVF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	140/521 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	53/153 (35%)
nlgn2b	NP_001159808.1	COesterase	47..611	CDD:278561	141/528 (27%)
nlgn2b	NP_001159808.1	Aes	<181..>279	CDD:223730	41/97 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740