DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and ACA8

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_200444.1	Gene:	ACA8 / 835733	AraportID:	AT5G56330	Length:	350	Species:	Arabidopsis thaliana

Alignment Length:	280	Identity:	69/280 - (24%)
Similarity:	106/280 - (37%)	Gaps:	88/280 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DFGYE--GRHGPEHW---SEDYARCS-GKHQSPINI-DQVSAVEKKFPKLEFFNFKVVPDNLQMT 84
            :|.||  |..||..|   ..::..|. ||.||||:: |:...|..||..|   ..:.:|.|..:.
plant   139 EFSYETKGNKGPAKWGTLDAEWKMCGIGKMQSPIDLRDKNVVVSNKFGLL---RSQYLPSNTTIK 200

  Fly    85 NNGHTVLVKMSYNEDEI-PSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELH 148
            |.||.:::|.......| .::||        ..||.:|.|:|      ..||..||.:.:..|.|
plant   201 NRGHDIMLKFKGGNKGIGVTIRG--------TRYQLQQLHWH------SPSEHTINGKRFALEEH 251

  Fly   149 VVLRNLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGE 213
            :|..:           ||...||:||.:.:|....        .|..::::.|.:..|:
plant   252 LVHES-----------KDKRYAVVAFLYNLGASDP--------FLFSLEKQLKKITDTH------ 291

  Fly   214 YISKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTANDDHLKNNFRPIQPLN 278
                                .|||    ...|   ::.||:...|:  |..|...:|.||:|.:|
plant   292 --------------------ASEE----HIRT---VSSKQVKLLRV--AVHDASDSNARPLQAVN 327

  Fly   279 DRTLY---------KNYIEI 289
            .|.:|         |.|..|
plant   328 KRKVYLYKPKVKLMKKYCNI 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	64/260 (25%)
ACA8	NP_200444.1	alpha_CA_prokaryotic_like	149..333	CDD:239398	61/254 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820