DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and ACA3

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_196038.1	Gene:	ACA3 / 830296	AraportID:	AT5G04180	Length:	277	Species:	Arabidopsis thaliana

Alignment Length:	303	Identity:	79/303 - (26%)
Similarity:	124/303 - (40%)	Gaps:	77/303 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVIAPILICASLVLAQ----DFGYEGRH--GPEHWSE---DYARC-SGKHQSPINIDQVSAVEKK 65
            |:....|..:|..||.    :|.|:...  .|..||.   ::..| :||.|||||:.
plant     5 ILFVTFLALSSSSLADETETEFHYKPGEIADPSKWSSIKAEWKICGTGKRQSPINLT-------- 61

  Fly    66 FPKL--------EFFNFKVVPDNLQMTNNGHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQF 122
             ||:        |.......|....:.|.|..:.||.   ||:    .|..:...|  .|:..|.
plant    62 -PKIARIVHNSTEILQTYYKPVEAILKNRGFDMKVKW---EDD----AGKIVINDT--DYKLVQS 116

  Fly   123 HFHWGENDTIGSEDLINNRAYPAELHVVLRNLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYE 187
            |:|      ..||..::.:....|||:|.:::|          .| :||:...|:.|:.:.
plant   117 HWH------APSEHFLDGQRLAMELHMVHKSVE----------GH-LAVIGVLFREGEPNA---- 160

  Fly   188 GFTNLLSQI-DRKGK---------SVNMTNPLPLGEYISKSVESYFSYTGSLTTPPCSEEVTWID 242
                .:|:| |:..|         |:...:|...|..::|    ::.|.||||||||:|:|.|..
plant   161 ----FISRIMDKIHKIADVQDGEVSIGKIDPREFGWDLTK----FYEYRGSLTTPPCTEDVMWTI 217

  Fly   243 FTTPIDITEKQLNAFRLLTANDDHLKNNFRPIQPLNDRTLYKN 285
            ......::.:|::.  |..|.....:.|.||.||||.|.:|.|
plant   218 INKVGTVSREQIDV--LTDARRGGYEKNARPAQPLNGRLVYLN 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	71/276 (26%)
ACA3	NP_196038.1	alpha_CA_prokaryotic_like	35..257	CDD:239398	70/270 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730