DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and ca15b

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	XP_005169499.1	Gene:	ca15b / 791844	ZFINID:	ZDB-GENE-040426-2222	Length:	320	Species:	Danio rerio

Alignment Length:	249	Identity:	72/249 - (28%)
Similarity:	120/249 - (48%)	Gaps:	33/249 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPDNLQMT---NNGHTVLVKMSYNEDEIPSVRGG 107
            |:|..||||||  |:|..|....|..|.:....|:..:|   |.|.::.|.:   :.:...|.||
Zfish    46 CNGTQQSPINI--VTANVKANANLTSFTYVGYNDSTALTVIKNTGTSIQVTL---DPKKMRVAGG 105

  Fly   108 PLAEKTPLGYQFEQFHFHWGENDTI-GSEDLINNRAYPAELHVVLRNLEYPDFASALDKDHGIAV 171
            .|    |..:...:||.|||....: |||..:|.:.:|.|||:|.:.:.        :....:||
Zfish   106 NL----PGRFASTEFHLHWGNGSAMPGSEHTVNGKRFPMELHIVNKPVS--------NTSDSLAV 158

  Fly   172 MAFFFQVGDKSTG---GYEGFTNLLSQIDRKGKSVNMTNPLPLGEYISKSVE--SYFSYTGSLTT 231
            :..|.:..:: ||   .::..|:.|::|.:.|...::.....:.:.:| .|:  .|:.|.|||||
Zfish   159 LGVFIEASNE-TGKPESWKTLTSYLTRIVKAGDKASLFRNFSMDDLLS-GVDRTKYYRYLGSLTT 221

  Fly   232 PPCSEEVTWIDFTTPIDITEKQLNAFRLL-----TANDDHLKNNFRPIQPLNDR 280
            |.|:|.|.|..|..||.::...::.|...     ::|...:.|.||.:||:|.|
Zfish   222 PNCNEGVIWTVFKDPIRVSRDLIDLFSTTVYINNSSNSPLMTNIFRSVQPVNGR 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	72/249 (29%)
ca15b	XP_005169499.1	alpha_CA_IV_XV_like	48..279	CDD:239391	71/247 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920