DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and CA8

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001308766.1	Gene:	CA8 / 767	HGNCID:	1382	Length:	290	Species:	Homo sapiens

Alignment Length:	281	Identity:	100/281 - (35%)
Similarity:	146/281 - (51%)	Gaps:	48/281 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPD-----NLQMTNN 86
            ::|||  .|.| |...:...:|::|||||::...|  :..|.|  .:.::.|:     :.::||:
Human    28 EWGYE--EGVE-WGLVFPDANGEYQSPINLNSREA--RYDPSL--LDVRLSPNYVVCRDCEVTND 85

  Fly    87 GHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFE--QFHFHWGENDTIGSEDLINNRAYPAELHV 149
            |||:.|.:....    .:.||||    |.|::||  :..||||..:..|||..:|.:|:|.|||:
Human    86 GHTIQVILKSKS----VLSGGPL----PQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHL 142

  Fly   150 VLRNLE-YPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKS-------VNMT 206
            :..|.. :.....|:.|.||||::|.|.|:| |...|.:..|.:|..|..||||       .|..
Human   143 IHWNSTLFGSIDEAVGKPHGIAIIALFVQIG-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTL 206

  Fly   207 NPLPLGEYISKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTAN-------- 263
            .|.||       :..|:.|.||||.|||||.||||.|..|:.|::.|:..||.|..:
Human   207 LPDPL-------LRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVE 264

  Fly   264 --DDHLKNNFRPIQPLNDRTL 282
              |..|.:||||.|||:||.:
Human   265 GCDGILGDNFRPTQPLSDRVI 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	99/277 (36%)
CA8	NP_001308766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
CA8	NP_001308766.1	alpha_CARP_VIII	35..289	CDD:239394	96/272 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820