Protein Alignment CAH2 and CA3

DIOPT Version :10

• Sequence 1: NP_648555.1
• Gene: CAH2 / 39390
• FlyBaseID: FBgn0027843
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 86/269 - (31%)
• Similarity: 142/269 - (52%)
• Gaps: 16/269 - (5%)

  Fly    24 LAQDFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPDNLQ-MTNNG 87
            :|:::||...:||:||.|.:....|::|||:.:.....  :..|.|:.::......:.: :.|||
Human     1 MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDI--RHDPSLQPWSVSYDGGSAKTILNNG 63

  Fly    88 HTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLR 152
            .|..|......|. ..:|||||    |..|:..|||.|||.:|..|||..::...|.||||:|..
Human    64 KTCRVVFDDTYDR-SMLRGGPL----PGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHW 123

  Fly   153 NLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYISK 217
            |.:|..|..||.:..||||:..|.::|.:: |.::.|.:.|.:|..|||....|...|  ..:..
Human   124 NPKYNTFKEALKQRDGIAVIGIFLKIGHEN-GEFQIFLDALDKIKTKGKEAPFTKFDP--SCLFP 185

  Fly   218 SVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTANDDH-----LKNNFRPIQPL 277
            :...|::|.||.|||||.|.:.|:....|:.::..|:...|.|.::.::     |.:|:||.||:
Human   186 ACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPI 250

  Fly   278 NDRTLYKNY 286
            |:|.:..::
Human   251 NNRVVRASF 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	34..286	CDD:459707	83/257 (32%)
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	86/267 (32%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		1/2 (50%)