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Protein Alignment CAH2 and CA2

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_000058.1	Gene:	CA2 / 760	HGNCID:	1373	Length:	260	Species:	Homo sapiens

Alignment Length:	271	Identity:	101/271 - (37%)
Similarity:	157/271 - (57%)	Gaps:	20/271 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LAQDFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPD---NLQMTN 85
            ::..:||...:|||||.:|:....|:.|||::||..:|  |..|.|:  ...|..|   :|::.|
Human     1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTA--KYDPSLK--PLSVSYDQATSLRILN 61

  Fly    86 NGHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVV 150
            |||...|:...::|: ..::|||| :.|   |:..|||||||..|..|||..::.:.|.||||:|
Human    62 NGHAFNVEFDDSQDK-AVLKGGPL-DGT---YRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLV 121

  Fly   151 LRNLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYI 215
            ..|.:|.||..|:.:..|:||:..|.:|| .:..|.:...::|..|..||||.:.||..|.| .:
Human   122 HWNTKYGDFGKAVQQPDGLAVLGIFLKVG-SAKPGLQKVVDVLDSIKTKGKSADFTNFDPRG-LL 184

  Fly   216 SKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTAN-----DDHLKNNFRPIQ 275
            .:|:: |::|.|||||||..|.||||....||.::.:|:..||.|..|     ::.:.:|:||.|
Human   185 PESLD-YWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQ 248

  Fly   276 PLNDRTLYKNY 286
            ||.:|.:..::
Human   249 PLKNRQIKASF 259

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.