DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and ca16b

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	XP_001919055.3	Gene:	ca16b / 569183	ZFINID:	ZDB-GENE-080818-1	Length:	1382	Species:	Danio rerio

Alignment Length:	324	Identity:	102/324 - (31%)
Similarity:	160/324 - (49%)	Gaps:	43/324 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FGYEGRHGPEHWSEDYARCSGKHQSPINI-DQVSAVEKKFPKLEFFNFKVVPDN-LQMTNNGHTV 90
            :.|.|.:||..|:..|..|..::|||::| |..:.|.::..:|....|:....| ..|.|.|.||
Zfish    55 WAYSGTYGPRRWASAYPECGERNQSPVDILDPETQVSQECQELTLDGFETKSSNRTTMKNTGKTV 119

  Fly    91 --LVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGE-NDTIGSEDLINNRAYPAELHVVLR 152
              ::|..|      .|||..|    |..::.|:..||||. |.:.|||..||.:.:|.|:.:...
Zfish   120 SIVLKNDY------FVRGAGL----PGRFKAEKVEFHWGSTNGSAGSEHSINGKKFPVEMQIYFY 174

  Fly   153 NL-EYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYIS 216
            |. ::...::|:.:...||.||.||||..|.....|.....|.::....|..|:.:.: |.:.:.
Zfish   175 NSDDFDSLSTAIKERRIIAAMAVFFQVATKDNIAAEPIIAGLKRVVHHEKETNLGSFI-LRDLLP 238

  Fly   217 KSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLL--TANDDH------LKNNFRP 273
            .|:.||:.|||||||||||:.|.||.|:.|:.::..||.||..:  |...||      |:||.||
Zfish   239 SSLGSYYRYTGSLTTPPCSKVVEWIIFSRPVYLSYHQLEAFYSIFTTEQQDHVKSVDYLRNNHRP 303

  Fly   274 IQPLNDRTLYKNYIEIPIHNMGSIPLVDA------ENAAGKWRAQAAAVLLPLVVLAALSRTSI 331
            ||.|:.|.::|:            .|:||      .:||....::..:.:...:.|..|:||::
Zfish   304 IQDLDSRRIFKS------------ALMDAWMPETMASAADTETSRVCSSIPDNMKLHPLNRTAL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	91/266 (34%)
ca16b	XP_001919055.3	alpha_CARP_receptor_like	62..314	CDD:239396	90/262 (34%)
		FN3	340..417	CDD:214495	4/16 (25%)
		Herpes_BLLF1	450..>557	CDD:330317
		PTPc	790..1057	CDD:214550
		PTPc	1089..1347	CDD:214550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810