DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and ca15a

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001075158.1	Gene:	ca15a / 553469	ZFINID:	ZDB-GENE-070424-7	Length:	324	Species:	Danio rerio

Alignment Length:	255	Identity:	87/255 - (34%)
Similarity:	129/255 - (50%)	Gaps:	29/255 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPDN---LQMTNNGHTVLVKMSYNEDEIPSVRGG 107
            |:|..||||||.....:|..  .|..|||.....|   :.|.|:|.:|:|.:   ::||.||:||
Zfish    46 CNGSSQSPINIVTAQVLENS--NLTQFNFTGFDANTTFISMANSGISVVVTL---DEEIMSVQGG 105

  Fly   108 PLAEKTPLGYQFEQFHFHWGENDTI-GSEDLINNRAYPAELHVVLRNLEYP---DFASALDKDHG 168
            .|    |..|..:|||.|||.:.:. |||..::.:.|..|||:|..:.:|.   ..|.|.:....
Zfish   106 DL----PGLYVSKQFHLHWGNSSSFPGSEHTVDGKQYAMELHIVNVHSKYNGSLSAALAANDSSA 166

  Fly   169 IAVMAFFFQVGDKST--GGYEGFTNLLSQIDRKGKS----VNMTNPLPLGEYISKSVESYFSYTG 227
            :||:.||.:..::::  .|:...|:.|..|...|.:    :|.|:...|.|.::|:  .|:.|.|
Zfish   167 LAVLGFFIEGTNEASKAKGWGVLTSFLRNITYSGNATVDIMNRTSMNSLLEGVNKT--KYYRYRG 229

  Fly   228 SLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLL----TANDDHLK-NNFRPIQPLNDRTL 282
            |||||.|:|.|.|..|..||.:....:|.|...    .|:...|. ||||.:||||.|.:
Zfish   230 SLTTPSCNEAVIWTVFKEPIKVNNNLINLFSTTVFAKNASAPVLNVNNFRGVQPLNGRVV 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	86/252 (34%)
ca15a	NP_001075158.1	alpha_CA_IV_XV_like	48..291	CDD:239391	86/253 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920