DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and CAH5

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001097988.2	Gene:	CAH5 / 50102	FlyBaseID:	FBgn0040629	Length:	302	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	84/270 - (31%)
Similarity:	135/270 - (50%)	Gaps:	21/270 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GRHGPEHWSEDY-ARC-SGKHQSPINI----DQVSAVEKKFPKLEFFNF-KVVPDNLQMTNNGHT 89
            |.:..:...:|: ..| ||::||||::    .::.|:    |:|.|.|: :.:...|.:||||||
  Fly    41 GEYNYDEQGDDWTGTCQSGENQSPIDLIFEDSKIVAI----PRLRFNNYDQPLQTPLVITNNGHT 101

  Fly    90 V-LVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRN 153
            . :|.......:.||:.|..|    |..::.:..|||||..:..|||..||.:.|..|:|:|.:|
  Fly   102 ANMVIPQTRGGQRPSINGSLL----PGNFEAQSVHFHWGSREAKGSEHAINFQRYDVEMHIVHKN 162

  Fly   154 LEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDR---KGKSVNMTNPLPLGEYI 215
            ..|.....|.....|:||:...|:..|:.|..:.|...:.:|:.|   ...:..:|..|.:|:.:
  Fly   163 TIYETMGEATMHPDGLAVLGVMFRAVDRQTSQHYGLNKIFNQLPRIVQYNSNATITGRLTVGQLL 227

  Fly   216 SKSVE-SYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQL-NAFRLLTANDDHLKNNFRPIQPLN 278
            ...|. .:|:|.||||||.|:|.|||..|...:|...:|: ..:.|..:....|.||:|.||..|
  Fly   228 GNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDYPRRQITKLWNLRDSRQRPLINNYRSIQDTN 292

  Fly   279 DRTLYKNYIE 288
            .|.:|...|:
  Fly   293 SRDVYYRTIQ 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	81/261 (31%)
CAH5	NP_001097988.2	Carb_anhydrase	43..294	CDD:215000	80/258 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27166
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	11	10.880