DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH2 and CAH8

DIOPT Version :9

Sequence 1:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001262833.1	Gene:	CAH8 / 42625	FlyBaseID:	FBgn0038956	Length:	303	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	93/286 - (32%)
Similarity:	134/286 - (46%)	Gaps:	33/286 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKL------EFFNFKVVPDNLQMTN 85
            ||.|:   .||.|.|.|..|.|..||||.|.:..|:....|.|      |||:     :.:.:.|
  Fly    27 DFDYK---SPERWPEKYPNCGGSEQSPIAISRRKAIPLNLPPLIFALYDEFFD-----ELVTIRN 83

  Fly    86 NGHTVLVKMSYNEDEI-PSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHV 149
            :||||..|:......: |.|.||.|.:    .|..|..|||||..::.|||.|:|.|.:..|:|:
  Fly    84 SGHTVEFKVPTTIYGVKPYVTGGLLRD----CYDAEAVHFHWGSPESKGSEHLLNGRRFDLEMHI 144

  Fly   150 VLRNLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYE-GFTNLLSQIDRKGK---SVNMTNPLP 210
            |.||.:|.:...|:....|:.|:|..|:|.......|: |.:.:.|.:...|.   |..:...|.
  Fly   145 VHRNTKYLNLEEAVKYSDGVTVLAVLFKVVRSGPFFYQPGLSEIFSSLLHLGNFNASYTVQERLT 209

  Fly   211 LGEYI-SKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAF-RLLTANDDHLKNNFRP 273
            ||..: |....::::|.|||||||||..|.|..|...:.|:.:.|..| .|.......|..||||
  Fly   210 LGSLLGSLDRGNFYTYKGSLTTPPCSPVVQWHVFGEVLPISHQDLPKFWNLRDERGRPLLKNFRP 274

  Fly   274 IQPLNDRTLYKNYIEIPIHNMGSIPL 299
            :|...:|.::        |....:||
  Fly   275 LQSQENRLIF--------HRQHIVPL 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	88/265 (33%)
CAH8	NP_001262833.1	Carb_anhydrase	31..281	CDD:215000	86/261 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27166
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	11	10.880