DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rh7 and mchr1.2

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001072243.1	Gene:	mchr1.2 / 779692	XenbaseID:	XB-GENE-1018376	Length:	360	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	76/347 - (21%)
Similarity:	145/347 - (41%)	Gaps:	55/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 EPPKSSTF--LIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPA---NILVMNLAICDFLMLIK 168
            :|..:.|:  :||..::.:|.::|.:||:.||:....:...|..:   :|.::||::.|.|.|:.
Frog    28 DPSSNVTYASVIMPTVFGVICLLGIIGNSVVIYTVFKKSKFRCSSSVPDIFIINLSVVDLLFLLG 92

  Fly   169 CPIAIYNNIKEGP-ALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRS 232
            .|..|:..:..|. ..|:..|.|...:...|...:...|||:::|||...|:|....:......:
Frog    93 MPFLIHQLLGNGVWHFGETMCTLITALDTNSQFTSTYILTAMSIDRYLATVYPFTSAKYRKPPIA 157

  Fly   233 YLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCIPLTS 297
            .::|.::|..| |.::.|.......:.:|.|.| .|.....|.|.....:....|..|:.||...
Frog   158 IMVICILWVLS-LLSITPVWMYARLIALPGGVL-GCGITLPNPESDIYWYTLYQFFLAFAIPFAV 220

  Fly   298 IVYSYFYILKVVFTASRIQSNKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHIT 362
            |..:|..||..:.::..:.:::......:|:.....||..::|:.|:|:.::          .|.
Frog   221 ISVAYRRILLKMASSEALTAHRSSRIRTKKVTRTAIAICLVFFICWAPFYVL----------QII 275

  Fly   363 PLGSMIPAL-----FCKTA------ACVDPYLY-----------------AATHPRFRVEVRMLF 399
            .|....|.|     :|...      :|::|::|                 |..||..|  :||.|
Frog   276 QLVMDQPTLAFHYAYCVAISMGYANSCINPFIYIILCETFRRRFIVSVQPAEDHPESR--IRMKF 338

  Fly   400 -------YGRGVLRRVSTTRSS 414
                   .|:.:|:.|..:..|
Frog   339 RTDPPSGSGQPLLQLVPVSTGS 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	32/125 (26%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	58/265 (22%)
mchr1.2	NP_001072243.1	7tmA_MCHR1	38..319	CDD:320460	63/292 (22%)
		TM helix 1	39..65	CDD:320460	8/25 (32%)
		TM helix 2	75..101	CDD:320460	8/25 (32%)
		TM helix 3	113..143	CDD:320460	9/29 (31%)
		TM helix 4	155..175	CDD:320460	4/20 (20%)
		TM helix 5	202..231	CDD:320460	8/28 (29%)
		TM helix 6	246..276	CDD:320460	7/39 (18%)
		TM helix 7	287..312	CDD:320460	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010