DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and SSTR1

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001040.1	Gene:	SSTR1 / 6751	HGNCID:	11330	Length:	391	Species:	Homo sapiens

Alignment Length:	364	Identity:	77/364 - (21%)
Similarity:	161/364 - (44%)	Gaps:	49/364 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NSSHSHSTGSTTSTAGSSATESSAVNVGKDHDKHV--NDSVSTGLSNYSNYPSYIHYRDKYDLSY 97
            :||.|.|.||.....||....:.|.:..::..::.  |.::|.|
Human    11 SSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEG--------------------- 54

  Fly    98 IAKVNPFWLQFEPPKSSTFLIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICD 162
                           ..:.::::.:|.::.:||..||:.||::......::|..||.::||||.|
Human    55 ---------------QGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD 104

  Fly   163 FLMLIKCPIAIYNNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRC 227
            .|:::..|..:.:.:......|.:.|||...|..::...:|..||.:::|||..||||::..|..
Human   105 ELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYR 169

  Fly   228 SRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIFMALF----FV 288
            ....:.::.|.:|..| |..::|.:....:....:|   |.:.:.|..| ||:.::..|    |:
Human   170 RPTVAKVVNLGVWVLS-LLVILPIVVFSRTAANSDG---TVACNMLMPE-PAQRWLVGFVLYTFL 229

  Fly   289 AAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMG 353
            ..:.:|:.:|...|..|:..:...:.....:.:.::|:|:..:|..::.::.:.|.|:.:|.::.
Human   230 MGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVN 294

  Fly   354 VFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFR 392
            ||..:...|.  |.:..:.....:|.:|.||......|:
Human   295 VFAEQDDATV--SQLSVILGYANSCANPILYGFLSDNFK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	36/121 (30%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	59/254 (23%)
SSTR1	NP_001040.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		10/38 (26%)
		7tmA_SSTR1	59..334	CDD:320636	65/280 (23%)
		TM helix 1	61..85	CDD:320636	7/23 (30%)
		TM helix 2	94..115	CDD:320636	9/20 (45%)
		TM helix 3	131..153	CDD:320636	6/21 (29%)
		TM helix 4	176..192	CDD:320636	4/16 (25%)
		TM helix 5	221..244	CDD:320636	4/22 (18%)
		TM helix 6	270..292	CDD:320636	4/21 (19%)
		TM helix 7	302..327	CDD:320636	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940