Protein Alignment Rh7 and LTB4R2

DIOPT Version :10

• Sequence 1: NP_524035.2
• Gene: Rh7 / 39389
• FlyBaseID: FBgn0036260
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_062813.2
• Gene: LTB4R2 / 56413
• HGNCID: 19260
• Length: 358
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 96/376 - (25%)
• Similarity: 153/376 - (40%)
• Gaps: 80/376 - (21%)

  Fly   108 FEPPKSST-------------FLIMAALYCLISVVGCVGNAFVIFMFANRKSLR-TP-ANILVMN 157
            :.||.:.|             ||::|||      :|..||.||::..|..:..| .| |..||::
Human     5 YRPPGNETLLSWKTSRATGTAFLLLAAL------LGLPGNGFVVWSLAGWRPARGRPLAATLVLH 63

  Fly   158 LAICDFLMLIKCPIAIYNNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHP-L 221
            ||:.|..:|:..|:.:....::...||...|:...:|..||...::.....::|.|...|..| |
Human    64 LALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFL 128

  Fly   222 QPLRRCSRLRS----YLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIF 282
            .|     ||||    ..::|.:|..:.|.|| ||     :||........|...: ...:.|...
Human   129 AP-----RLRSPALARRLLLAVWLAALLLAV-PA-----AVYRHLWRDRVCQLCH-PSPVHAAAH 181

  Fly   283 MALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNK-DKAKTEQKLAFIVAAIIGLWFLAWSPY 346
            ::|..:.|:.:|...::..|      ..|.:|::..: ...:...::..:|:||:..:.|.|:||
Human   182 LSLETLTAFVLPFGLMLGCY------SVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPY 240

  Fly   347 -AIVAMMGVFGL---ERHITPLGSMIPALFCKTAA------CVDPYLYAAT--------HPRFRV 393
             |:..:..|..|   |..:..||....|....|.|      .|:|.||..|        .|||
Human   241 HAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRF-- 303

  Fly   394 EVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTS----TTGEG-GMGD 439
             :..||.|.|..|....:|..         |..|||:    ..|:| |.||
Human   304 -LTRLFEGSGEARGGGRSREG---------TMELRTTPQLKVVGQGRGNGD 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_GPCRs	118..395	CDD:475119	76/302 (25%)
		TM helix 1	119..143	CDD:320207	8/23 (35%)
		TM helix 2	152..173	CDD:320207	7/20 (35%)
		TM helix 3	189..211	CDD:320207	3/21 (14%)
		TM helix 4	234..250	CDD:320207	5/15 (33%)
		TM helix 5	280..303	CDD:320207	3/22 (14%)
		TM helix 6	329..351	CDD:320207	8/22 (36%)
		TM helix 7	363..388	CDD:320207	10/38 (26%)
LTB4R2	NP_062813.2	7tm_GPCRs	21..300	CDD:475119	75/302 (25%)
		TM helix 1	23..47	CDD:410628	10/29 (34%)
		TM helix 2	58..79	CDD:410628	7/20 (35%)
		TM helix 3	95..117	CDD:410628	3/21 (14%)
		TM helix 4	140..156	CDD:410628	5/16 (31%)
		TM helix 5	179..202	CDD:410628	4/28 (14%)
		TM helix 6	223..245	CDD:410628	8/21 (38%)
		TM helix 7	267..292	CDD:410628	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..358		12/43 (28%)