DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and Oprk1

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_038965287.1	Gene:	Oprk1 / 29335	RGDID:	69426	Length:	431	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	84/332 - (25%)
Similarity:	155/332 - (46%)	Gaps:	46/332 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 QFEPPKSSTFL--IMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKC 169
            |.||...|..:  |:.|:|.::.|||.|||:.|:|:......::|..||.:.|||:.|.|:....
  Rat    99 QLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM 163

  Fly   170 PI--AIYNNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRS 232
            |.  |:|  :......||:.|::...:...:...:|.|||.:::|||..|.||::.|...:.|::
  Rat   164 PFQSAVY--LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKA 226

  Fly   233 YLIILLIWCYSFLFAVMPALDIGLSVYVPEGF-------LTTCSFDYLNKEMP-ARIFMAL-FFV 288
            .:|.:.||        :.|..:|:|..|..|.       :..||..:.:.|.. ..:||.: .||
  Rat   227 KIINICIW--------LLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFV 283

  Fly   289 AAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMG 353
            .|:.||:..|:..|..::..:.:...:..:::|.:..:::..:|..::.::.:.|:|..|..::.
  Rat   284 FAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVE 348

  Fly   354 VFGLERHITPLGSMIPALFC----KTAACVDPYLYAATHPRFR---------VEVRMLFYGRGVL 405
            ..|...|.|.:.|..  .||    .|.:.::|.|||.....|:         :::||
  Rat   349 ALGSTSHSTAVLSSY--YFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRM-------- 403

  Fly   406 RRVSTTR 412
            .|.||.|
  Rat   404 ERQSTNR 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	37/123 (30%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	63/265 (24%)
Oprk1	XP_038965287.1	7tmA_Kappa_opioid_R	111..392	CDD:320219	74/292 (25%)
		TM helix 1	113..137	CDD:320219	10/23 (43%)
		TM helix 2	146..167	CDD:320219	8/20 (40%)
		TM helix 3	183..205	CDD:320219	4/21 (19%)
		TM helix 4	228..244	CDD:320219	5/23 (22%)
		TM helix 5	275..298	CDD:320219	8/22 (36%)
		TM helix 6	324..346	CDD:320219	4/21 (19%)
		TM helix 7	360..385	CDD:320219	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940