DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and CMKLR2

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001091669.1	Gene:	CMKLR2 / 2825	HGNCID:	4463	Length:	355	Species:	Homo sapiens

Alignment Length:	346	Identity:	79/346 - (22%)
Similarity:	139/346 - (40%)	Gaps:	48/346 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VNDSVSTGLSNYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLIMAALYCLISVVGCVG 133
            :.|...|....:.||        .|||.|.:..:.  |:.:........:...||||..|:|..|
Human     1 MEDLEETLFEEFENY--------SYDLDYYSLESD--LEEKVQLGVVHWVSLVLYCLAFVLGIPG 55

  Fly   134 NAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAI-YNNIKEGPALGDIACRLYGFVGGL 197
            ||.||: |...|..:|...:..:||||.||:.|:..|:.| |..:......|...|:...|...|
Human    56 NAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119

  Fly   198 SGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPE 262
            :...::..||.|:||.|..::||:...|..:...|.::|:.||..:.|..       |.::|
Human   120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-------GPALY--- 174

  Fly   263 GFLTTCSFD-----YLN--KEMP------ARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASR 314
             |..|..|:     |.|  |..|      ..:...:.|:..|..||.::...|..::..|...|.
Human   175 -FRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI 238

  Fly   315 IQSNKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVF----GLERHITPLGSMIPALFCKT 375
            :.|::.        .:.:..::..:.:.|:||.:.::..:.    ....|:...|..:.......
Human   239 LISSRH--------FWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFL 295

  Fly   376 AACVDPYLYAATHPRFRVEVR 396
            .:|::|.||.....:|:...|
Human   296 NSCLNPILYVLISKKFQARFR 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	39/122 (32%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	60/268 (22%)
CMKLR2	NP_001091669.1	7tmA_GPR1	39..315	CDD:320247	69/295 (23%)
		TM helix 1	41..65	CDD:320247	12/24 (50%)
		TM helix 2	73..94	CDD:320247	8/20 (40%)
		TM helix 3	111..133	CDD:320247	5/21 (24%)
		TM helix 4	156..172	CDD:320247	5/22 (23%)
		TM helix 5	204..227	CDD:320247	4/22 (18%)
		TM helix 6	245..267	CDD:320247	3/21 (14%)
		TM helix 7	283..308	CDD:320247	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940