DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and Gpr1

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001343974.1	Gene:	Gpr1 / 241070	MGIID:	2385324	Length:	353	Species:	Mus musculus

Alignment Length:	390	Identity:	88/390 - (22%)
Similarity:	157/390 - (40%)	Gaps:	92/390 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LSNYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFL-----IMAALYCLISVVGCVGNAF 136
            |.|||           |.|.|       :.|...|:...:|     |...||.|..|:|..|||.
Mouse    12 LDNYS-----------YALDY-------YSQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAI 58

  Fly   137 VIFM--FANRKSLRTPANILVMNLAICDFLMLIKCPIAI-YNNIKEGPALGDIACRLYGFVGGLS 198
            ||::  |..:|::.|   :..:||||.||:.::..|:.| |..:......|...|::..|:..|:
Mouse    59 VIWLMGFKWKKTVTT---LWFLNLAIADFIFVLFLPLYISYVALSFHWPFGLWLCKVNSFIAQLN 120

  Fly   199 GTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEG 263
            ...::..||.|:||||..::||....|..:...|.::::|:|..:.|..       |.::|
Mouse   121 MFSSVFFLTVISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLG-------GPTLY---- 174

  Fly   264 FLTT--------CSFDYLNKE---MPARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQS 317
            |..|        |..::...|   |...:...:.|:..|..||.::...|..::        .:.
Mouse   175 FRDTMEVNNHIICYNNFQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLI--------FKM 231

  Fly   318 NKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHIT-----------PLGSMIPAL 371
            .|......:|..:::.:::..:.:.|:||   .:..::.|..|..           ||.:.:..|
Mouse   232 KKRNILISRKHLWMILSVVIAFLVCWTPY---HLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFL 293

  Fly   372 FCKTAACVDPYLYA----ATHPRFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTT 432
                .:|::|.||.    ....|||..|      ..||:     ||.:......:.:.:||::.|
Mouse   294 ----NSCLNPILYVLISKTFQARFRASV------AEVLK-----RSLWEASCSGTVSEQLRSAET 343

Fly 433 432
Mouse 344 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	38/124 (31%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	59/275 (21%)
Gpr1	NP_001343974.1	7tmA_GPR1	39..313	CDD:320247	67/302 (22%)
		TM helix 1	40..66	CDD:320247	11/25 (44%)
		TM helix 2	72..97	CDD:320247	9/27 (33%)
		TM helix 3	110..140	CDD:320247	10/29 (34%)
		TM helix 4	152..172	CDD:320247	5/26 (19%)
		TM helix 5	201..226	CDD:320247	5/24 (21%)
		TM helix 6	237..267	CDD:320247	4/32 (13%)
		TM helix 7	281..306	CDD:320247	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030