DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and Sstr3

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001343890.1	Gene:	Sstr3 / 20607	MGIID:	98329	Length:	428	Species:	Mus musculus

Alignment Length:	374	Identity:	90/374 - (24%)
Similarity:	163/374 - (43%)	Gaps:	84/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCP-IAIYNNIKEG 180
            ::::.:|.::.|||.:||:.||::.....|..:..::.::|||:.|.|.::..| :|..|.:...
Mouse    46 ILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYW 110

  Fly   181 PALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFL 245
            | .|.:.|||...|.|::...:|..||.:::|||..||||.:..|..:...:..:...:|..|.:
Mouse   111 P-FGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAV 174

  Fly   246 FAVMPALDIGLSVY--VPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCI----PLTSIVYSYFY 304
             .|:|.:     |:  ||.| ::||   ::....||..:...|.:....:    ||..|...|..
Mouse   175 -VVLPVV-----VFSGVPRG-MSTC---HMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLL 229

  Fly   305 I-LKVVFTASRIQSN----------KDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLE 358
            | :||..|..|:::.          :.:.::|:::..:|.|::.|:.|.|.|:.::.::.|
Mouse   230 IVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNV---- 290

  Fly   359 RHITPLGSMIPALF---------CKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSS 414
              :.||... ||.|         ....:|.:|.||.....||:...|.      :|.|.|
Mouse   291 --VCPLPEE-PAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRR------ILLRPS----- 341

  Fly   415 YMTRSRSSFTHRLRTSTTGEGGMGDHRMENYLMNNNLMMVPEETEENEE 463
                      .|:|:...|.|                  .||:|||.|:
Mouse   342 ----------RRIRSQEPGSG------------------PPEKTEEEED 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	36/122 (30%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	68/277 (25%)
Sstr3	NP_001343890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		7tm_GPCRs	46..333	CDD:391938	76/304 (25%)
		TM helix 1	48..72	CDD:341315	8/23 (35%)
		TM helix 2	81..102	CDD:341315	6/20 (30%)
		TM helix 3	118..140	CDD:341315	7/21 (33%)
		TM helix 4	163..179	CDD:341315	3/16 (19%)
		TM helix 5	205..228	CDD:341315	4/22 (18%)
		TM helix 6	262..287	CDD:341315	6/24 (25%)
		TM helix 7	301..326	CDD:341315	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..428		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940