DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and npr-24

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_510833.3	Gene:	npr-24 / 187897	WormBaseID:	WBGene00020086	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	80/327 - (24%)
Similarity:	145/327 - (44%)	Gaps:	49/327 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 EPPKSSTFLIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAI 173
            :|.|:...|    .:||.:::|...|.||:......:.:||.:||.:.|||:.|.|.|...|:::
Worm    15 DPIKTVAHL----TWCLTALIGIPANLFVLAAIVYFRDMRTISNIYIFNLAVADLLFLCGIPVSL 75

  Fly   174 Y-NNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLR-RCSR------L 230
            : .:..:|...|.|.|:||.....:|...:...:..::.|||..|..|:|... |.::      :
Worm    76 FAQSSHDGWIWGPIMCKLYISGNAVSQFASAVFIAILSFDRYLAVCRPIQSKSFRTTQAAFALSV 140

  Fly   231 RSYLIILLIWCYSFLFAVM-------------PALDIGLSVYVPEGFLTTCSFDYLN---KEMPA 279
            .::::::|.....|||..:             ..|.:| :|.|.|. .|..:...||   :.|.|
Worm   141 AAWIMVILEMTPLFLFVKLIKSSSAGEARGGSCMLFVG-NVTVLES-ATEMNETLLNEIEQNMLA 203

  Fly   280 --RIFMALFFVAAYCIPLTSIVYSYF-YILKVVFTASRIQSNKDKAKTE-QKLAFIVAAIIGLWF 340
              |.|::..|..:|.|||.::.|.|| .|||:.....::|:.:...|.. .|:..:..||:..:.
Worm   204 SRRFFISYTFALSYLIPLVAVWYFYFKIILKMCQRKRQMQTKRTATKKRTTKVTIMGLAIVISYT 268

  Fly   341 LAWSPYAIVAMMGVFGLERHITPLGSMIPALFCKT---------AACVDPYLYAATHPRFRVEVR 396
            ..|.|:.||.    :.:|.::......:  |||.|         .:..:|:||......|:..::
Worm   269 HCWLPFWIVQ----WSIEANLFEKSKYL--LFCCTHFAFALQYINSAANPFLYVFLSDSFQKNIQ 327

  Fly   397 ML 398
            .|
Worm   328 KL 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	33/129 (26%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	70/287 (24%)
npr-24	NP_510833.3	7tm_GPCRs	25..326	CDD:391938	76/308 (25%)
		TM helix 1	25..46	CDD:341315	6/20 (30%)
		TM helix 2	53..80	CDD:341315	9/26 (35%)
		TM helix 3	91..121	CDD:341315	7/29 (24%)
		TM helix 4	133..155	CDD:341315	1/21 (5%)
		TM helix 5	185..234	CDD:341315	16/49 (33%)
		TM helix 6	251..281	CDD:341315	7/33 (21%)
		TM helix 7	293..319	CDD:341315	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010