DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and npr-28

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_509416.2	Gene:	npr-28 / 181089	WormBaseID:	WBGene00018886	Length:	518	Species:	Caenorhabditis elegans

Alignment Length:	420	Identity:	82/420 - (19%)
Similarity:	174/420 - (41%)	Gaps:	57/420 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NPFWLQFEPPKSSTFLIMAALYCLISVVGCVGNAFVIFMFANRKS-------------LRTPANI 153
            :|..:|||      .:.:..||..::|.|..||.:|:.....:.|             :::.|.:
Worm    29 DPMEIQFE------IMFVMVLYSCLAVTGVGGNCWVLIKVIKQLSGCSSNRSRPYKTVVQSSAYV 87

  Fly   154 LVMNLAICDFLMLIKCPIAIYNNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVV 218
            .::.|::.|...||..|:.:.:........|..||:|..|...::.:.:...|||:::|||..|.
Worm    88 YLIILSVVDLFSLIPVPMIVTDVYVNHFPFGLWACKLSYFCEAINKSLSPMVLTALSVDRYIAVC 152

  Fly   219 HPLQPLRRCSRLRSYLIILLIWCYS----FLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPA 279
            ||.....|.::   :.:.:|..|:|    |:..|.....:.:.....:..:..|:||:  .:..:
Worm   153 HPTLYWLRTTK---FSLGVLAVCFSVSLIFIIPVTKKATMQVMKDNTDEEIIKCAFDH--GDSAS 212

  Fly   280 RIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQKLAFIV---AAIIGLWFL 341
            .:|.....:..|.:||..|...|..||..:|..:|. |...| ||...|..:|   ..::..:|:
Worm   213 YVFDTAQAIVCYLVPLFIICAVYLAILHKLFIHTRF-STVGK-KTSISLGRVVKCSVMVVAFYFI 275

  Fly   342 AWSPY------AIVAMMGVFGLERHITPLGSMIPALFCKTAACVD-PYLYAATHPR--FRVEVRM 397
            .|:||      .:|........:.:.|.:..::.|:..:....:: .|.:.....:  ..:|:.:
Worm   276 CWTPYWTMRIHYLVTRFIETNSDGNSTVIDEVVAAVAEEVQDGIETSYFFGLISKKRMHNIEIAL 340

  Fly   398 LFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTTGEG---------GMGDHRMENYLMNNNLMM 453
            ::    :|..::..:|::.....|.....|| |..|.|         .:.|:......:|.:|..
Worm   341 IY----ILHSLTYAQSAFNWLFYSFLNRNLR-SNNGRGNGTRSAANTSVFDNGNATSTVNTSLTP 400

  Fly   454 VPEETEENEEIVVVAEINNSISSVMEQSKF 483
            :.:..::....:..|.::.. |::|::|.|
Worm   401 IWKNIQQMGSHIKTAGLDTR-SALMKKSPF 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	31/138 (22%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	57/277 (21%)
npr-28	NP_509416.2	7tm_classA_rhodopsin-like	41..363	CDD:381740	65/332 (20%)
		TM helix 1	41..64	CDD:381740	7/22 (32%)
		TM helix 2	86..107	CDD:381740	5/20 (25%)
		TM helix 3	123..145	CDD:381740	5/21 (24%)
		TM helix 4	167..183	CDD:381740	4/15 (27%)
		TM helix 5	213..236	CDD:381740	5/22 (23%)
		TM helix 6	260..285	CDD:381740	5/24 (21%)
		TM helix 7	338..363	CDD:381740	3/28 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010