DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and Sstr3

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_598206.1	Gene:	Sstr3 / 171044	RGDID:	620308	Length:	428	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	90/374 - (24%)
Similarity:	164/374 - (43%)	Gaps:	84/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCP-IAIYNNIKEG 180
            ::::.:|.::.|||.:||:.||::.....|..:..::.::|||:.|.|.::..| :|..|.:...
  Rat    46 ILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYW 110

  Fly   181 PALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFL 245
            | .|.:.|||...|.|::...:|..||.:::|||..||||.:..|..:...:.::...:|..|.:
  Rat   111 P-FGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAV 174

  Fly   246 FAVMPALDIGLSVY--VPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCI----PLTSIVYSYFY 304
             .|:|.:     |:  ||.| ::||   ::....||..:...|.:....:    ||..|...|..
  Rat   175 -VVLPVV-----VFSGVPRG-MSTC---HMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLL 229

  Fly   305 I-LKVVFTASRIQSN----------KDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLE 358
            | :||..|..|:::.          :.:.::|:::..:|.|::.|:.|.|.|:.::.::.|
  Rat   230 IVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNV---- 290

  Fly   359 RHITPLGSMIPALF---------CKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSS 414
              :.||... ||.|         ....:|.:|.||.....||:...|.      :|.|.|
  Rat   291 --VCPLPEE-PAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRR------ILLRPS----- 341

  Fly   415 YMTRSRSSFTHRLRTSTTGEGGMGDHRMENYLMNNNLMMVPEETEENEE 463
                      .|:|:...|.|                  .||:|||.|:
  Rat   342 ----------RRVRSQEPGSG------------------PPEKTEEEED 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	36/122 (30%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	68/277 (25%)
Sstr3	NP_598206.1	7tm_GPCRs	46..333	CDD:421689	76/304 (25%)
		TM helix 1	47..73	CDD:410628	8/25 (32%)
		TM helix 2	80..106	CDD:410628	7/25 (28%)
		TM helix 3	117..147	CDD:410628	11/29 (38%)
		TM helix 4	159..181	CDD:410628	4/27 (15%)
		TM helix 5	204..233	CDD:410628	6/28 (21%)
		TM helix 6	259..289	CDD:410628	7/29 (24%)
		TM helix 7	301..326	CDD:410628	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..428		10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940