DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and ltb4r2a

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_017212293.2	Gene:	ltb4r2a / 100535026	ZFINID:	ZDB-GENE-140106-272	Length:	402	Species:	Danio rerio

Alignment Length:	395	Identity:	81/395 - (20%)
Similarity:	151/395 - (38%)	Gaps:	89/395 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 AALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAIYNNIKEGPALG 184
            ||:..|:.::|..||.|:::....|...|:...:|::|||..|..:::..|..:...::......
Zfish    59 AAILSLVFLLGVPGNVFIMWSILARARRRSITTLLILNLAFADGFLMLLTPFFMVYLVQRSWVFS 123

  Fly   185 DIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVM 249
            ...|::..::...:...:|..:..::|.|...:|.|.:...:..|.....:::.:|
Zfish   124 LALCKVLYYLCCANMYASIFMIMLMSLHRLVAIVWPKRVGAKTERKMLTRVLVGLW--------- 179

  Fly   250 PALDIGLSVYV------------PEGFLTTCSFDYLNKEMPARIFM-ALFFVAAYCIPLTSIVYS 301
             .|.:|||..|            ||.|:..|    ::.|....:.. ::..:..:.:|...|:.|
Zfish   180 -VLALGLSAPVLAFRNILSDSKKPEKFVCDC----IHPETQYEVMQYSMETLLGFLLPYGVIIGS 239

  Fly   302 YFYILKVVFTASRIQSNKDKAK-TEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLG 365
            |..||:      ||:..:.:.: ..:||..::....||:   |.||.|:.|:.|...   :.|.|
Zfish   240 YTCILR------RIRKTRFRRRIRSEKLILVIVVTFGLF---WLPYHIINMVQVTAA---LLPEG 292

  Fly   366 S--------------MIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSSYM 416
            |              .:.:.....::|::|.||.             |.|:           ||:
Zfish   293 SAAKHRLQEIRANMRALTSTVAFVSSCINPVLYT-------------FAGK-----------SYI 333

  Fly   417 TRSRSSFTHRLRTSTTGEGGMGDHRMENYLMNNNLMMVPEETEENEEIV-----VVAEIN-NSIS 475
            .|...:|..||...|..|......|     .|.|.....:||:|.:.|.     .:..|| ||:.
Zfish   334 RREGLAFMARLFEGTALESTRKIRR-----SNQNSRERDKETDEGDSIKDKDSDSINTINANSVI 393

  Fly   476 SVMEQ 480
            .|..|
Zfish   394 KVAPQ 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	21/121 (17%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	52/278 (19%)
ltb4r2a	XP_017212293.2	7tm_GPCRs	56..337	CDD:333717	63/327 (19%)
		TM helix 1	58..82	CDD:320095	7/22 (32%)
		TM helix 2	91..112	CDD:320095	6/20 (30%)
		TM helix 3	128..150	CDD:320095	1/21 (5%)
		TM helix 4	173..189	CDD:320095	5/25 (20%)
		TM helix 5	218..241	CDD:320095	3/22 (14%)
		TM helix 6	256..281	CDD:320095	8/27 (30%)
		TM helix 7	304..329	CDD:320095	5/37 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930