DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rh7 and gpr149

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_002933305.3	Gene:	gpr149 / 100497416	XenbaseID:	XB-GENE-983069	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	87/451 - (19%)
Similarity:	150/451 - (33%)	Gaps:	146/451 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 QFEP-------PKSSTFLIMAALYCL---ISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAIC 161
            :|||       || :||...|.::.|   |::...:|:...:......|| ::..::||.:|::.
Frog    14 RFEPDLGIMDMPK-ATFTFNALVFSLTLIITLTVFLGSIISLVSLLKMKS-KSTLSLLVTSLSVD 76

  Fly   162 DFLMLIKCPIAIY------NNIKEGPALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHP 220
            |.:.::  |.:|:      .:....| |...|..||.|.|..|      .|.|.::..||...
Frog    77 DLVSVV--PASIFMLHQWTTHALPQP-LCSAAAFLYLFQGISS------NLKASSIICYNFYT-- 130

  Fly   221 LQPLRRCSRLRSY----------LIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNK 275
                  .::|.||          ..:..||..|.|.:.:|....|.......|..|.|:..|:
Frog   131 ------VNKLGSYETTKISVKIFCAVATIWVISILISAIPFFGWGRFHTTSWGCFTDCTSSYI-- 187

  Fly   276 EMPARIFMALFFVAAYCI------PLT---------------SIVYSYF---------------- 303
                 :|:...:...:||      |||               .|...|.
Frog   188 -----LFLFGLYSLCFCILVILSAPLTHQLLCSDDHQHINYKDISKGYLTPTTPLGSNASSLSPD 247

  Fly   304 -------------YIL-KVVF------TASRIQSNKDKAKTEQKLAFIVA-----AIIGLW-FLA 342
                         |:. :.||      |:..:|.:.:..:..:.:..:.|     .|:.|. .:.
Frog   248 NPVGKTLKNSNEKYVSPEAVFKRSVAETSGDVQHSSNSVRGGRNITVLYAQKRFSLILALTKVIL 312

  Fly   343 WSPYAIVAMMGVFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRR 407
            |.|..|..::      :||....|    |..:|.:.:...|.||..|.|.:..|......|.:
Frog   313 WLPIMIQMVV------QHIVAFQS----LSFETLSFILSLLSAAATPLFVLSERWRHLPCGCI-- 365

  Fly   408 VSTTRSSYMTRS------RSSFTHRLR-------------TSTTGEGGMGDHRMENYLMNN 449
            ::..|::|.|.:      :..|...|.             ...|||..:..|.:.||...|
Frog   366 INCKRNTYETSAEENQIKKRGFDFNLSFNKGYGIYKISQDNHATGENSISYHNLINYDCEN 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	30/140 (21%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	58/329 (18%)
gpr149	XP_002933305.3	7tmA_GPR149	34..364	CDD:320139	66/364 (18%)
		TM helix 1	35..59	CDD:320139	3/23 (13%)
		TM helix 2	67..88	CDD:320139	6/22 (27%)
		TM helix 3	103..126	CDD:320139	8/28 (29%)
		TM helix 4	148..164	CDD:320139	4/15 (27%)
		TM helix 5	193..216	CDD:320139	5/22 (23%)
		TM helix 6	299..321	CDD:320139	5/21 (24%)
		TM helix 7	331..356	CDD:320139	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100