DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh7 and sstr2

DIOPT Version :9

Sequence 1:	NP_524035.2	Gene:	Rh7 / 39389	FlyBaseID:	FBgn0036260	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_002935929.1	Gene:	sstr2 / 100496382	XenbaseID:	XB-GENE-953419	Length:	372	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	93/413 - (22%)
Similarity:	170/413 - (41%)	Gaps:	84/413 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 STGLSNYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLIMAALYCLISVVGCVGNAFVI 138
            :..:||.:.|         ||::..|                  |:..:|.::.:||..||..||
Frog    32 NASISNSTTY---------YDMTSNA------------------ILTFIYFVVCIVGLCGNTLVI 69

  Fly   139 FMFANRKSLRTPANILVMNLAICDFLMLIKCP-IAIYNNIKEGPALGDIACRLYGFVGGLSGTCA 202
            ::......::|..||.::||||.|.|.::..| :|:...:...| .|...||:...|.|::...:
Frog    70 YVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWP-FGKAICRIVMTVDGINQFTS 133

  Fly   203 IGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALD-IGLSVYVPEGFLT 266
            |..||.:::|||..||||::..:......:.::...:|..| |..:||.:. .|:..|...|
Frog   134 IFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMVNAAVWTVS-LLVIMPIMTYAGVQSYHGRG--- 194

  Fly   267 TCSFDYL-NKEMPARIFMALFFVAAYCIPLTSIVYSY-FYILKVVFTASRIQSNKDKAKTEQKLA 329
            :|:..:. |.......|:...|:..:.:||:.|...| |.|:||..:..|:.|:|.| ::|:|:.
Frog   195 SCTIIWPGNSSAWYTGFIIYAFILGFLVPLSIICLCYLFIIIKVKSSGIRVGSSKRK-RSEKKVT 258

  Fly   330 FIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLGSM-----IPALFCKTAACVDPYLYAATHP 389
            .:|:.::.::...|.|:.|..:..|..|   |.|...:     ...:.....:|.:|.|||....
Frog   259 RMVSIVVAVFIFCWLPFYIFNVSSVSLL---IVPTPGLKAMWDFVVVLSYANSCANPILYAFLSD 320

  Fly   390 RFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRL---RTSTTGEGGMGDHRMENYLMNNNL 451
            .|                            :.||.:.|   :.|...|....|.:.:...:|
Frog   321 NF----------------------------KKSFQNVLCLSKVSGMDEVDRSDSKQDKSRLN--- 354

  Fly   452 MMVPEETEENEEIVVVAEINNSI 474
                 ||.|.:..::..::..||
Frog   355 -----ETTETQRTLLNGDLQTSI 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh7	NP_524035.2	7tm_4	125..>247	CDD:304433	36/122 (30%)
Rh7	NP_524035.2	7tm_1	133..384	CDD:278431	67/259 (26%)
sstr2	XP_002935929.1	7tmA_SSTR2	48..326	CDD:320637	76/332 (23%)
		TM helix 1	49..75	CDD:320637	8/25 (32%)
		TM helix 2	82..108	CDD:320637	10/25 (40%)
		TM helix 3	119..149	CDD:320637	10/29 (34%)
		TM helix 4	161..183	CDD:320637	5/22 (23%)
		TM helix 5	208..237	CDD:320637	8/28 (29%)
		TM helix 6	252..282	CDD:320637	6/29 (21%)
		TM helix 7	294..319	CDD:320637	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010