DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and NRXN2

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_011543672.1	Gene:	NRXN2 / 9379	HGNCID:	8009	Length:	1715	Species:	Homo sapiens

Alignment Length:	1147	Identity:	274/1147 - (23%)
Similarity:	462/1147 - (40%)	Gaps:	265/1147 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 FNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSR 258
            |.|.....|||...||.|:.:.|...|:|...||:|::: |...||..|.||...:.|.::|||.
Human   292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVWLVINLGSG 355

  Fly   259 VMTSL--SVGSLLDDNVWHDVVISRNQRD---------------IIFSVDRVI-VRGRIQGEFTR 305
            ...:|  .|....:||.||||.::||.|.               :..|||.:: ..|..|.::|.
Human   356 AFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM 420

  Fly   306 LNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYA 368
            |..:...|:||.||..:  |..|..||.|||:::.:.:.:|...:....:.|:..:..:.:..:.
Human   421 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFR 485

  Fly   369 CPS-PPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVML------------------H 414
            |.. ..:.||||.:..:||.|..:...:..::|..|||.|..|::|                  .
Human   486 CEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQR 550

  Fly   415 HDFYS----GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKW-H-SFVISIEKNRLILN 473
            .|:::    .|:|.:.|:.|...|.|:...:          :.|||:| | .|.....|..:.:|
Human   551 ADYFAMELLDGHLYLLLDMGSGGIKLRASSR----------KVNDGEWCHVDFQRDGRKGSISVN 605

  Fly   474 IDQRPMTTTKSMQVA-TGAQYYIAGGKD-----------------KNGFVGCMRLISVDGNYKLP 520
            ....|...|...::. ..::.|:.|..:                 :.|:|||:|.:.:||.   .
Human   606 SRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGR---S 667

  Fly   521 QDWVKGEEVCCGDDVVVDAC--QMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNN 583
            :| ::|.....|...|...|  :.:.:|...||::.|:|.:....|.|||..||:.|.||.....
Human   668 RD-LRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT 731

  Fly   584 PLSC-------LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVITTLSHSQEHT 638
            .||.       :.|.|..|.                |...|:..|.|.   |.::.|.|.....|
Human   732 VLSYDGSMYMKIMLPNAMHT----------------EAEDVSLRFMSQRAYGLMMATTSRESADT 780

  Fly   639 TTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWI 703
            ..::             .|..|:::...|:    |   |...|       :||.||
Human   781 LRLE-------------LDGGQMKLTVNLD----C---LRVGC-------APSAAG--------- 809

  Fly   704 SRHNQPMDYWAGALPGSRKCECGILGKCHDPTKW-------------CNCDSNSLEWMEDGGDIR 755
               ..|...:||             .|.:| .:|             .:.|:.::|....|..:|
Human   810 ---KGPETLFAG-------------HKLND-NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMR 857

  Fly   756 ------------EKEYLPVRAVKF-GD------TGTP-LDE-KMGRYTLGPLRCEGDDLF----- 794
                        |:.::.|....| |.      .|.| :|: |.|..|.    ||.:..|
Human   858 LEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITY----CELNARFGLRAI 918

  Fly   795 -SNVVTFRIADASINLPPFDMGHSGDIYLEFRTT-QENSVIFHATGPTDYIKLSLNGGNKLQFQY 857
             ::.|||:...:.:.|.......|..::.:|:|| .:..::|::....|:|.:.|..| .:.:.:
Human   919 VADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG-YIHYVF 982

  Fly   858 QAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEAR-LVVDGSIKAEVREPPGPVRALHLTSDLVI 921
            ..|:||..:...:...:|||.||.|.|.|:..... |.:|   ...|.:.....|.|.|..:|.|
Human   983 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID---SRTVTQHSNGARNLDLKGELYI 1044

  Fly   922 GATTE-----------YRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG---RCESNPCL 972
            |..::           .|||:.||:.::.|||::.||...:...:..:..||.|   .|....|.
Human  1045 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1109

  Fly   973 NNGTCIERYDGYSCDCRWSAFKGPICADEIGVNL---RSSSIIRYEFEGSFR-STIAENIRVGFT 1033
            |.|.|::::||::|||..:::.||:|.|. |...   :..::|.|.:..:.| ||..:.:.|||:
Human  1110 NQGVCLQQWDGFTCDCTMTSYGGPVCNDP-GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFS 1173

  Fly  1034 TTIPKGFLLGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKN 1097
            |......|:.. |::..|:||.:.| :.|.:..:|:.|.:...|..|......|:||.:.|.|..
Human  1174 THQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSG 1237

  Fly  1098 GGSTVVLKVDNYEPVEY-----NFDIKASADAQ------------------------FNNIQYMY 1133
            |.:|  |:||:: ||..     |||.:..|.|:                        ||:...:.
Human  1238 GNAT--LQVDSW-PVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIK 1299

  Fly  1134 IGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLG 1175
            ||..:.... |.|.||.:.::.:..|.|..:.:|  ||::.|
Human  1300 IGGRDQGRP-FQGQVSGLYYNGLKVLALAAESDP--NVRTEG 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058	54/165 (33%)
		LamG	376..514	CDD:238058	38/179 (21%)
		EGF	546..575	CDD:278437	11/28 (39%)
		Laminin_G_2	824..943	CDD:280389	35/131 (27%)
		EGF_CA	966..998	CDD:238011	12/31 (39%)
		Laminin_G_2	1032..1156	CDD:280389	38/153 (25%)
		4.1m	1239..1255	CDD:128590
NRXN2	XP_011543672.1	LamG	28..184	CDD:238058
		Laminin_G_2	318..456	CDD:280389	45/138 (33%)
		LamG	516..666	CDD:214598	32/159 (20%)
		EGF_CA	694..727	CDD:238011	13/32 (41%)
		Laminin_G_2	760..893	CDD:280389	30/185 (16%)
		Laminin_G_2	949..1077	CDD:280389	35/131 (27%)
		Laminin_G_2	1172..1320	CDD:280389	38/152 (25%)
		Syndecan	1640..>1679	CDD:279386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910