DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and NRXN1

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_001129131.1 Gene:NRXN1 / 9378 HGNCID:8008 Length:1547 Species:Homo sapiens


Alignment Length:1315 Identity:300/1315 - (22%)
Similarity:490/1315 - (37%) Gaps:366/1315 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 DYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMV 250
            :||:.   |.|:....|||.:.||.|:.:.|...|||...||:|::: |...||..|.||:..:.
Human   314 EYIAT---FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374

  Fly   251 LNLDLGSRVMTSL--SVGSLLDDNVWHDVVISRNQR---------------DIIFSVDRVI-VRG 297
            |.::|||....:|  .|....:||.||||.::||.|               .:..|||.:: ..|
Human   375 LVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTG 439

  Fly   298 RIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLF 360
            ..|.::|.|..:...|:||.|:..:  |..|..||.|||:.:.:.:.:....:....:.|:..:.
Human   440 YTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 504

  Fly   361 TRVNTIYACPS-PPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVML-------HH-- 415
            ......:.|.: ..:.|:||.|..||:.|..:...:..::||.|||.|..|::|       |.  
Human   505 IHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKD 569

  Fly   416 ---------DFYS----GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWH--SFVISI 465
                     ||::    .|:|.:.|:.|...|.:|...|          :.|||:|:  .|....
Human   570 AKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLK----------KVNDGEWYHVDFQRDG 624

  Fly   466 EKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKN-----------------GFVGCMRLISV 513
            ....:.:|..:.|.|.....::.........||..:|                 |:|||:|.:.:
Human   625 RSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 689

  Fly   514 DGNYKLPQDWVK-----GEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGY 573
            ||..|..:...:     |.:..|..:..       ..|..|||::.|:|......:.|||..|||
Human   690 DGQSKDIRQMAEVQSTAGVKPSCSKETA-------KPCLSNPCKNNGMCRDGWNRYVCDCSGTGY 747

  Fly   574 AGAVCHTSNNPLSC-------LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVI 628
            .|..|......||.       :.|..|.|.                |...|:..|.|.   |.::
Human   748 LGRSCEREATVLSYDGSMFMKIQLPVVMHT----------------EAEDVSLRFRSQRAYGILM 796

  Fly   629 TTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSR----LFNS 689
            .|.|.....|..::             .||.::::...|:    |   :..:|.||:    ||  
Human   797 ATTSRDSADTLRLE-------------LDAGRVKLTVNLD----C---IRINCNSSKGPETLF-- 839

  Fly   690 PSEAG-NFRPFSWWISR-------------HNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNC 740
               || |.....|...|             ..|.|   .|.:.|                     
Human   840 ---AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAM---TGQMAG--------------------- 877

  Fly   741 DSNSLEWME-DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLR------------CEGDD 792
            |...||:.. :.|.|.|:.||......|               :|.|:            |:..|
Human   878 DHTRLEFHNIETGIITERRYLSSVPSNF---------------IGHLQSLTFNGMAYIDLCKNGD 927

  Fly   793 L----------FSNV----VTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGP-TDY 842
            :          |.|:    |||:...:.:.|.......|..::.:|:||..:.:|.:.:|. .|:
Human   928 IDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDF 992

  Fly   843 IKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLV-VDGSIKAEVREP 906
            |.:.|..| .|.:.:..|:|...:...::..||||.||.|.:.|:......| :|..|..::   
Human   993 IVVELVKG-YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI--- 1053

  Fly   907 PGPVRALHLTSDLVIGATTE-----------YRDGYVGCIRALLLNGKMVDL-------KEYSKR 953
            ....|.|.|.|||.||...:           .::|:.||:.::.|||::.||       ....:|
Human  1054 TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIER 1118

  Fly   954 GLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNL---RSSSIIRYE 1015
            |..|.||    .|:.:.|.|.|.|::::||:||||..::|.||:|.|. |...   :....|.|:
Human  1119 GCEGPST----TCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDP-GTTYIFSKGGGQITYK 1178

  Fly  1016 FEGSFR-STIAENIRVGFTTTIPKGFLLGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIF 1078
            :..:.| ||.|:.:.:||:|...:..|:.. ||:..|:||.:.| :.|.:...|:.|.:...|..
Human  1179 WPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNVGTDDIAIEE 1242

  Fly  1079 PKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEY----NFDIKASADAQ-------------- 1125
            .......|:||.:.|.|..|.:|  |:||::..:|.    |.|.:..|.|:              
Human  1243 SNAIINDGKYHVVRFTRSGGNAT--LQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEW 1305

  Fly  1126 ----------FNNIQYMYIGKNE-----------------------SMTDGFVGCVSRVQFDDIY 1157
                      ||:...:.||..|                       :..|..:..|..|:.....
Human  1306 LLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEV 1370

  Fly  1158 PLKLMFQQNPPKNVKSLGTQLTEDFCGV--------EPVTHPPIEIETRPPPLV-------DEEK 1207
            |..:..:.........:.|.:.|....:        :|.|..||. :|....||       |:|.
Human  1371 PSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPIS-QTTDDILVASAECPSDDED 1434

  Fly  1208 L------------------RKAY--------------NEVDSVLLACLLVILFLLLILMFFLIGR 1240
            :                  |:.|              ..|..::.|..|.||.||     :.:.:
Human  1435 IDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILL-----YAMYK 1494

  Fly  1241 YLHRHKGDYLTHEDQ 1255
            |.:|.:|.|  |.|:
Human  1495 YRNRDEGSY--HVDE 1507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572
FA58C 57..184 CDD:238014
LamG 192..340 CDD:238058 54/167 (32%)
LamG 376..514 CDD:238058 41/178 (23%)
EGF 546..575 CDD:278437 12/28 (43%)
Laminin_G_2 824..943 CDD:280389 36/131 (27%)
EGF_CA 966..998 CDD:238011 14/31 (45%)
Laminin_G_2 1032..1156 CDD:280389 36/175 (21%)
4.1m 1239..1255 CDD:128590 5/15 (33%)
NRXN1NP_001129131.1 LamG 30..190 CDD:238058
LamG 340..486 CDD:214598 46/146 (32%)
LamG 543..692 CDD:214598 35/158 (22%)
EGF_CA 720..753 CDD:238011 13/32 (41%)
Laminin_G_2 786..917 CDD:280389 35/194 (18%)
Laminin_G_2 973..1101 CDD:280389 36/131 (27%)
Laminin_G_2 1196..1344 CDD:280389 33/150 (22%)
Syndecan 1472..>1511 CDD:279386 13/43 (30%)
4.1m 1492..1510 CDD:128590 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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