DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and NRXN3

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_011535665.1 Gene:NRXN3 / 9369 HGNCID:8010 Length:1687 Species:Homo sapiens


Alignment Length:1325 Identity:293/1325 - (22%)
Similarity:493/1325 - (37%) Gaps:379/1325 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 FNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSR 258
            |.|:..:.|||.:.||.|:.:.|...|||...||::::: |...||..|.|||..:.|.::|||.
Human   265 FRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHT-GKSADYVNLALKDGAVSLVINLGSG 328

  Fly   259 VMTSL--SVGSLLDDNVWHDVVISRNQRD--------IIFSVDRVI-VRGRIQGEFTRLNLNREL 312
            ...::  .|....:||.||||.::||.|.        :..|||.:: ..|..|.::|.|..:...
Human   329 AFEAIVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFF 393

  Fly   313 YLGGVPNVQE--GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPS-PPI 374
            |:||.|:..:  |..|..||.|||:.:.:.:.:....:.....:.:..:......::.|.: ..:
Human   394 YVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATL 458

  Fly   375 YPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLH-H-----------------DFYS-- 419
            .|:.|.|..:::.|..:...:..::||.|||.|..|::|. |                 ||::  
Human   459 DPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVE 523

  Fly   420 --GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQR--PMT 480
              .|.|.:.|:.|...|.:|...|          :.|||:|:...|..:.....::::.|  |.|
Human   524 LLDGNLYLLLDMGSGTIKVKATQK----------KANDGEWYHVDIQRDGRSGTISVNSRRTPFT 578

  Fly   481 TTKSMQV--ATGAQYYIAGGKDKN-----------------GFVGCMRLISVDGNYKLPQDWVKG 526
            .:...::  ..|..|  .||..:|                 |:|||:|.:.:||..|..:...:.
Human   579 ASGESEILDLEGDMY--LGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEM 641

  Fly   527 EEVCCGDDVVVDACQMID--RCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSC-- 587
            :...    .|..:|..:.  :|:..||::..:|......|.|||..|||.|..|....:.||.  
Human   642 QNAA----GVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDG 702

  Fly   588 -----LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVITTLSHSQEHTTTVDGF 644
                 :.:..|.|.                |...|:..|.|.   |.::.|.|.....|..::  
Human   703 SMYMKIIMPMVMHT----------------EAEDVSFRFMSQRAYGLLVATTSRDSADTLRLE-- 749

  Fly   645 QEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSE--AGNFRPFSWW----I 703
                       .|..::::...|:    |   :..:|.||:   .|..  ||.....:.|    :
Human   750 -----------LDGGRVKLMVNLD----C---IRINCNSSK---GPETLYAGQKLNDNEWHTVRV 793

  Fly   704 SRHNQPM------DYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWME-DGGDIREKEYLP 761
            .|..:.:      |...|.:.|                     |...||:.. :.|.:.||.|:.
Human   794 VRRGKSLKLTVDDDVAEGTMVG---------------------DHTRLEFHNIETGIMTEKRYIS 837

  Fly   762 VRAVKFGDTGTPLDEKMGRYTLGPLR------------CEGDD--------------LFSNVVTF 800
            |....|               :|.|:            |:..|              :.::.|||
Human   838 VVPSSF---------------IGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTF 887

  Fly   801 RIADASINLPPFDMGHSGDIYLEFRTTQ-ENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPL 864
            :...:.::|.......|..::.:|:||. :..::|::....|:|.:.|..| .:.:.:..|:||.
Human   888 KTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG-YIHYVFDLGNGPN 951

  Fly   865 GVNVGTSYHLNDNNWHTVSVER-NRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTE-- 926
            .:...:...||||.||.|.:.| |.....|.||..:..:|   ....:.|.|..||.:....:  
Human   952 VIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQV---INGAKNLDLKGDLYMAGLAQGM 1013

  Fly   927 ---------YRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG---RCESNPCLNNGTCIE 979
                     .|||:.||:.::.|||::.||...:......|..||.|   .|:.:.|.|.|.|::
Human  1014 YSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQ 1078

  Fly   980 RYDGYSCDCRWSAFKGPICADEIGVNL--RSSSIIRYEFEGSFR-STIAENIRVGFTTTIPKGFL 1041
            :::|::|||..:::.|..|.|.....:  :|..:|.|.:..:.| ||.::.:.|||:||:..|.|
Human  1079 QWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGIL 1143

  Fly  1042 LGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLK 1105
            :.. |:...|::|.:.| ..|.:..||:.|.....|...:.....|:||.:.|.|..|.:|  |:
Human  1144 VRIDSAPGLGDFLQLHI-EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNAT--LQ 1205

  Fly  1106 VDNYE----------------------PVEYNFDI------KASADAQFNNIQYMYI-GKNESMT 1141
            |||:.                      |.:||..:      |......||....:.| ||::...
Human  1206 VDNWPVNEHYPTGNTDNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRL 1270

  Fly  1142 DGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLG--------------TQLT------------- 1179
              |.|.:|.:.:|.:..|.:..:.||  |:|..|              ||.|             
Human  1271 --FQGQLSGLYYDGLKVLNMAAENNP--NIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMET 1331

  Fly  1180 -----------------------------------EDFCGVEPVT------------------HP 1191
                                               |||...||.|                  .|
Human  1332 TTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGRSGGELVIPLLVEDPLATP 1396

  Fly  1192 PIEIE----TRPP---PLVD-EEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGD 1248
            ||...    |.||   ||:. .|..:.:.:......|.||                         
Human  1397 PIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCL------------------------- 1436

  Fly  1249 YLTHEDQGADGADDPDDAVLHSTTG 1273
                .|||:||.|  ||.::.|..|
Human  1437 ----SDQGSDGCD--DDGLVISGYG 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572
FA58C 57..184 CDD:238014
LamG 192..340 CDD:238058 53/158 (34%)
LamG 376..514 CDD:238058 40/180 (22%)
EGF 546..575 CDD:278437 11/28 (39%)
Laminin_G_2 824..943 CDD:280389 35/131 (27%)
EGF_CA 966..998 CDD:238011 10/31 (32%)
Laminin_G_2 1032..1156 CDD:280389 38/153 (25%)
4.1m 1239..1255 CDD:128590 0/15 (0%)
NRXN3XP_011535665.1 LamG 35..181 CDD:238058
EGF 202..232 CDD:394967
LamG 286..425 CDD:214598 45/139 (32%)
LamG 482..631 CDD:214598 37/160 (23%)
EGF_CA 659..692 CDD:238011 12/32 (38%)
LamG 720..854 CDD:214598 32/192 (17%)
Laminin_G_2 911..1039 CDD:396680 35/131 (27%)
LamG 1103..1282 CDD:238058 45/183 (25%)
Syndecan 1613..>1648 CDD:395821
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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