DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and CNTNAP4

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_207837.2	Gene:	CNTNAP4 / 85445	HGNCID:	18747	Length:	1308	Species:	Homo sapiens

Alignment Length:	1336	Identity:	420/1336 - (31%)
Similarity:	655/1336 - (49%)	Gaps:	137/1336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPL---MERAVLTATSSL-TERGPDKARLN---GN 76
            |..||||.......|:|.      :.|||:.||   :.:|..:::|.| :..||..||||   |.
Human     9 LKTLLLLSTQNWNRVEAG------NSYDCDDPLVSALPQASFSSSSELSSSHGPGFARLNRRDGA 67

  Fly    77 AAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM 141
            ..|:|:.:....:|.:|||:...|..:||.|...:..:||.|::.:||.|..|:.|   ..|..:
Human    68 GGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWNWKQY---RQEDSI 129

  Fly   142 --FKGNSDGNSIHYNVFEVPIIAQWVRINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRY 202
              |.||::.:|:.|...:..|.|:::|..|..|:  .||.||:|::||.|.||.:..:|...:.|
Human   130 WGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLY 194

  Fly   203 DLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLG------SRVMT 261
            ...::.::..|:.|..:|||..::|::::..|..||:..|||:..::.|.::.|      :..:.
Human   195 RFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLV 259

  Fly   262 SLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGL-I 325
            :|::||||||..||.|:|.|..:.:.|:||........:|||..:||:.|:..||:|...:.: .
Human   260 NLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIPAPGKSVSF 324

  Fly   326 VQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKG 390
            ..:||.|||||:|:|..:.|.:.|..    :..:....|..::|..|...||||.:..|::.|..
Human   325 PHRNFHGCLENLYYNGVDIIDLAKQQ----KPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPD 385

  Fly   391 YENSQRLNVSFYFRTYEETGVMLHHD--FYSGGYLKVFLEFGKVKIDLKVKDK------ARIILD 447
            :...:.::.:|.|||:.:.|::|..:  ..|||.| :||..||:|.:|....|      |.:
Human   386 FSGEEEVSATFQFRTWNKAGLLLFSELQLISGGIL-LFLSDGKLKSNLYQPGKLPSDITAGV--- 446

  Fly   448 NYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSM---QVATGAQYYIAGGKDKN------- 502
                :.|||:|||..:|.:||.|.:.:|.:..:....:   |:.:|..||..|..||:
Human   447 ----ELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKS 507

  Fly   503 ---GFVGCMRLISVDGNYKLPQDWVKGEEVCCGD--DVVVDACQMIDRCNPNPCQHKGLCHQNSR 562
               ||.|||||||:.|..   .|.:..::...|:  |:.:|:|.:.|||.||.|:|.|.|.|:..
Human   508 PLGGFQGCMRLISISGKV---VDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWS 569

  Fly   563 EFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLN----LDVDGSGPLEPFPVTCEFYS 623
            .|.|:|.:|||.||.||.|....||.|.|:      |.|.:    :|.|||||||||.:.|....
Human   570 TFHCNCTNTGYRGATCHNSIYEQSCEAYKH------RGNTSGFYYIDSDGSGPLEPFLLYCNMTE 628

  Fly   624 DGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFN 688
              ...|.:.|:....|.|........:.....|.|:..|::|.:||:..|.|..:|.|:.|||.|
Human   629 --TAWTIIQHNGSDLTRVRNTNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTYYCKKSRLVN 691

  Fly   689 SPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGD 753
            .....    |.|||:.|.|:...||.|:.|..:||.||:.|.|.|...:||||::..||..|.|.
Human   692 KQDGT----PLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQYYCNCDADRNEWTNDTGL 752

  Fly   754 IREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSG 818
            :..||:|||..:...|||....|  ..|.||||.|:||..|.|..:|....:.::.|.|....|.
Human   753 LAYKEHLPVTKIVITDTGRLHSE--AAYKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSA 815

  Fly   819 DIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVS 883
            |:...|:||..:.|.....|..|:|::.|.....:.|.:..|:||..::|.:..|.|||.||.|.
Human   816 DVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVR 880

  Fly   884 VERNRKEARLVVDGSIKAEVREPPGPVRA---LHLTSDLVIGATTEYRDGYVGCIRALLLNGKMV 945
            ||||.|||.|.||   :...:..|.|...   |.|.|.|.:|.|...:.|::||||:|.|||..:
Human   881 VERNMKEASLQVD---QLTPKTQPAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTL 942

  Fly   946 DLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRS 1008
            ||:|.: :....:..||.|.|.|  ..|.|.|.|.||..|:.|||.:||:.||.|::||.....|
Human   943 DLEERA-QVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGS 1006

  Fly  1009 SSIIRYEFE-------------GSFRSTI---AENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQI 1057
            .|.:.|.|:             .||...:   .|.|:..|.||.....|| |.|:...|||::.|
Human  1007 GSSVIYNFQENYLLSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLL-FVSSFYKEYLSVII 1070

  Fly  1058 SNSGHLRCVFDFG-FERQEII-FPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKA 1120
            :.:|.|:..:... ::..::: |..|:...||.|.:...|:.|  .|.:::|:    .....:..
Human  1071 AKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEG--VVFIEIDD----NRRRQVHL 1129

  Fly  1121 SADAQFNNIQYMYIGKNESMTD-----------GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSL 1174
            |:..:|:.::.:.:|:....:|           ||.||:|.||...:.|||.....:.|..|...
Human  1130 SSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVT 1194

  Fly  1175 GTQLTEDFCGVEPVTHPPIEIET-----RPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILM 1234
            | .:||..|..:|.|.......|     ....:.|.|.|..|.....:|:...:.|::|:||.:.
Human  1195 G-HVTESSCMAQPGTDATSRERTHSFADHSGTIDDREPLANAIKSDSAVIGGLIAVVIFILLCIT 1258

  Fly  1235 FFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHS 1270
              .|...:::.|..|...|.:.::..|.. :|||.|
Human  1259 --AIAVRIYQQKRLYKRSEAKRSENVDSA-EAVLKS 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	48/149 (32%)
		FA58C	57..184	CDD:238014	43/134 (32%)
		LamG	192..340	CDD:238058	48/154 (31%)
		LamG	376..514	CDD:238058	51/158 (32%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	46/121 (38%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	33/136 (24%)
		4.1m	1239..1255	CDD:128590	3/15 (20%)
CNTNAP4	NP_207837.2	FA58C	54..176	CDD:238014	41/124 (33%)
		FA58C	55..177	CDD:214572	41/124 (33%)
		Laminin_G_2	212..341	CDD:280389	45/128 (35%)
		LamG	371..521	CDD:238058	50/157 (32%)
		EGF	553..584	CDD:278437	15/30 (50%)
		FReD	592..>639	CDD:294064	19/54 (35%)
		COLFI	604..>687	CDD:295304	25/84 (30%)
		LamG	794..938	CDD:238058	49/146 (34%)
		EGF_CA	962..996	CDD:238011	16/33 (48%)
		Laminin_G_2	1046..1176	CDD:280389	33/136 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2858
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	667	1.000	Inparanoid score	I757
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm41743
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	LDO	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840