DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and CNTNAP1

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_003623.1 Gene:CNTNAP1 / 8506 HGNCID:8011 Length:1384 Species:Homo sapiens


Alignment Length:1379 Identity:410/1379 - (29%)
Similarity:652/1379 - (47%) Gaps:201/1379 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTAT--SSLTERGPDKARLNGNAAWTP 81
            |.|:||...:|     |:.:..|..|.:...||..|::..::  |.||  .|..|||:|.:.|:|
Human     6 LFCILLAAVSG-----AEGWGYYGCDEELVGPLYARSLGASSYYSLLT--APRFARLHGISGWSP 63

  Fly    82 VENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYV----NPTSEPQMF 142
            .....|.:|.:||.....:|.:||.|..::.::||.|::.|.|..:.|..:.    |.|     |
Human    64 RIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNST-----F 123

  Fly   143 KGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDR--ISMRVELYGCDYISENLYFNGTGLVRYDLR 205
            .||.:.:::..:.......|:::||.|..|:.|  |.:|:.||||.|.::.|||:|...:.|...
Human   124 FGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFP 188

  Fly   206 REPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLS 264
            |....|..:...|.|||...:|:::::.|.||||..|:|:...::|::.|||..:      |::|
Human   189 RGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVS 253

  Fly   265 VGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGG-VPNVQEGLIVQQ 328
            .|.:|:|..||.|.:.|..||:.|::|..:.|..:.|:|.||||:.|:::|| |...::.|..:.
Human   254 AGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRH 318

  Fly   329 NFSGCLENIYFNSTNF--IRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGY 391
            ||.||:||:.||..|.  :.|.:.|....||      ...:.|..|..:|:.|....:||::.|:
Human   319 NFRGCIENVIFNRVNIADLAVRRHSRITFEG------KVAFRCLDPVPHPINFGGPHNFVQVPGF 377

  Fly   392 ENSQRLNVSFYFRTYEETGVMLHHDFYSG-GYLKVFLEFGKVKIDLKVKDKARIILDNYDDQF-- 453
            ....||.|||.|||::.||::|......| |::::.|..|:|.:.:....:.::       ||  
Human   378 PRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKL-------QFAA 435

  Fly   454 ----NDGKWHSFVISIEKNRLILNIDQ---RPMTTTKSMQVATGAQYYIAG----------GKDK 501
                |||.||......::|..:::||.   ..:..:..:.:.||..|:..|          ..::
Human   436 GYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQ 500

  Fly   502 NGFVGCMRLISVDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSRE 563
            ..|.|||.|:.|||   |..|    |:|..:....:|:.|.|.:.|||:||.|:|.|.|:|:..:
Human   501 TAFHGCMELLKVDGQLVNLTL----VEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDD 561

  Fly   564 FFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVI 628
            |.|.|..|||.|..|||.....||.|.:  ...:...|..:|.||||||:||.|.|:. .:.|..
Human   562 FICYCELTGYKGETCHTPLYKESCEAYR--LSGKTSGNFTIDPDGSGPLKPFVVYCDI-RENRAW 623

  Fly   629 TTLSHSQEHTTTVDGFQEPGSFEQSIMY-DANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSE 692
            |.:.|.:..||.|.|......|..:|.| :|:..::.||.|.|..|.|.:.:||.:|||.|:   
Human   624 TVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNT--- 685

  Fly   693 AGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREK 757
            ||.: |:|:||.|:.:...||.|:.||.::|.||:...|.||..:||||::..:|..|.|.:...
Human   686 AGGY-PYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFV 749

  Fly   758 EYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYL 822
            ::|||..|..|||.....|  .::.|.||||.||....|.::|. ..|::..||....||.|:..
Human   750 DHLPVTQVVIGDTNRSTSE--AQFFLRPLRCYGDRNSWNTISFH-TGAALRFPPIRANHSLDVSF 811

  Fly   823 EFRTTQENSVIF-HATGP-----TDYIKLSLNGGNKLQFQYQAGSGPLGVNV-GTSYHLNDNNWH 880
            .|||:..:.|.. :..||     ..|:::.||....:.|.:..|:|...:.| ...:..||:.||
Human   812 YFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWH 876

  Fly   881 TVSVERNRKEARLVVDGSIKAEVREP----PGPVRA---LHLTSDLVIGATTEYRDGYVGCIRAL 938
            .|..|.|.|:|||.||       ..|    |.|::.   :.....|.:|:....|..:|||:||:
Human   877 LVRAEINVKQARLRVD-------HRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAM 934

  Fly   939 LLNGKMVDLKEYSKRGLYGISTGCVGRCESN--PCLNNGTCIERYDGYSCDCRWSAFKGPICADE 1001
            .|||..::| |.......|.|..|.|.|...  ||.:.|.|:|||..|:|||..:||.||.|..:
Human   935 RLNGVTLNL-EGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHD 998

  Fly  1002 IGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIP---KGFLLGFSS----------------- 1046
            ||......:.:||..:.:.||...|...: .:..:|   .|::.|:.:                 
Human   999 IGGFFEPGTWMRYNLQSALRSAAREFSHM-LSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDY 1062

  Fly  1047 ---------------NLTGE------------------------YLTIQISNSGHLRCVFDFGFE 1072
                           |:|||                        |:.:.|.:.|.|:..:..|..
Human  1063 PRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTS 1127

  Fly  1073 RQEIIFPKKHFGLGQYHDMHFMR--KNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIG 1135
            ........:....||.|.::..|  :|    :.::||.:...|..|.:  ..|:|.::.:.:|:|
Human  1128 PYVYQLTTRPVTDGQPHSINITRVYRN----LFIQVDYFPLTEQKFSL--LVDSQLDSPKALYLG 1186

  Fly  1136 K-----------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKN---VKSLGTQ--LTEDFCG 1184
            :           ....|.||.||:|.|:|:::.|||..|:...|..   .::|..|  |:|..||
Human  1187 RVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCG 1251

  Fly  1185 VEP--VTHPPIEIET--RPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYL--H 1243
            ..|  |:..|.|::.  .||..       ..|::...|.:....::.||||.|:..|:..||  |
Human  1252 AMPRLVSEVPPELDPWYLPPDF-------PYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNH 1309

  Fly  1244 RHKGDYLTHEDQGA 1257
            |:||.|.|:|.:.|
Human  1310 RYKGSYHTNEPKAA 1323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 42/146 (29%)
FA58C 57..184 CDD:238014 38/134 (28%)
LamG 192..340 CDD:238058 54/154 (35%)
LamG 376..514 CDD:238058 40/157 (25%)
EGF 546..575 CDD:278437 14/28 (50%)
Laminin_G_2 824..943 CDD:280389 39/132 (30%)
EGF_CA 966..998 CDD:238011 16/33 (48%)
Laminin_G_2 1032..1156 CDD:280389 33/195 (17%)
4.1m 1239..1255 CDD:128590 9/17 (53%)
CNTNAP1NP_003623.1 FA58C 36..167 CDD:238014 39/137 (28%)
LamG 175..330 CDD:238058 54/154 (35%)
LamG 362..513 CDD:238058 40/157 (25%)
EGF 544..575 CDD:306513 15/30 (50%)
FReD 584..>658 CDD:294064 26/76 (34%)
LamG 787..937 CDD:238058 44/157 (28%)
LamG 1083..1218 CDD:214598 26/140 (19%)
4.1m 1304..1322 CDD:128590 9/17 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1319..1384 2/5 (40%)
SH3-binding. /evidence=ECO:0000255 1328..1369
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 208 1.000 Domainoid score I2858
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 667 1.000 Inparanoid score I757
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48725
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 1 1.000 - - FOG0000323
OrthoInspector 1 1.000 - - otm41743
orthoMCL 1 0.900 - - OOG6_101349
Panther 1 1.100 - - O PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X247
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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