DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap1

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_008766344.1	Gene:	Cntnap1 / 84008	RGDID:	70902	Length:	1387	Species:	Rattus norvegicus

Alignment Length:	1364	Identity:	395/1364 - (28%)
Similarity:	632/1364 - (46%)	Gaps:	216/1364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YDCNQ----PLMERAV-------LTATSSLTERGPDKARLN------GNAAWTPVENTYNHFLTL 92
            |.||:    ||..|::       |..|:..       |||:      |.:.|:|.....|.:|.:
  Rat    24 YGCNEELVGPLYARSLGASSYYGLFTTARF-------ARLHALAPFVGISGWSPRIGDPNPWLQI 81

  Fly    93 DLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDG----NSIHY 153
            ||.....:|.:||.|..::.::||.|::.|.|..:.|..:.........|...:|.    :.:||
  Rat    82 DLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQQGHNATFFGNVNDSAVVRHDLHY 146

  Fly   154 NVFEVPIIAQWVRINPTRWHDR--ISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESI 216
            :     ..|:::||.|..|:.|  |.:|:.:|||.|.|..|||:|...:.|..:|....|..:..
  Rat   147 H-----FTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSNILYFDGDDAISYRFQRGASQSLWDVF 206

  Fly   217 RFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWH 275
            .|.|||...:|:::::.|:||||..|:|:...::|::.|||..:      |::|.|.:|:|..||
  Rat   207 AFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDLSWH 271

  Fly   276 DVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGG-VPNVQEGLIVQQNFSGCLENIYF 339
            .|.:.|..|:...::|..:.|..:.|:|.||||..|:::|| |...::.|..:.||.||:||:.:
  Rat   272 YVRVDRYGREANLTLDGYVHRFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIY 336

  Fly   340 NSTNF--IRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFY 402
            |..|.  :.|.:.|....||      |..:.|..|..:|:.|....:||::.|:....||.|||.
  Rat   337 NRINIAEMAVQRHSRITFEG------NVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFR 395

  Fly   403 FRTYEETGVMLHHDFYSG-GYLKVFLEFGKVKIDLKVKDKARIILDNYDDQF------NDGKWHS 460
            |||::.||::|......| |::::.|..|:|.:.:....:.::       ||      |||.||.
  Rat   396 FRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIAQTGRKKL-------QFAAGYRLNDGFWHE 453

  Fly   461 FVISIEKNRLILNIDQ---RPMTTTKSMQVATGAQYYIAG----------GKDKNGFVGCMRLIS 512
            .....::|..:::||.   ..:..:..:.:.||..|:..|          ..::..|.|||.|:.
  Rat   454 VNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLK 518

  Fly   513 VDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYA 574
            |||   |..|    |:..::....:|:.|.|.:.|||:||.|:|.|.|:|:..:|.|.|..|||.
  Rat   519 VDGQLVNLTL----VEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYK 579

  Fly   575 GAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTT 639
            |..||......||.|.:  ...:...|..:|.||||||:||.|.|:. .:.|..|.:.|.:..||
  Rat   580 GVTCHEPLYKESCEAYR--LSGKYSGNYTIDPDGSGPLKPFVVYCDI-RENRAWTVVRHDRLWTT 641

  Fly   640 TVDGFQEPGSFEQSIMY-DANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWI 703
            .|.|......|..:|.| :|:..::.||.|.|..|.|.:.:||.:|||.|:   ||.: |:|:||
  Rat   642 RVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNT---AGGY-PYSFWI 702

  Fly   704 SRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFG 768
            .|:.:...||.|:.||.::|.||:...|.||...||||::..:|..|.|.:...::|||..|..|
  Rat   703 GRNEEQHFYWGGSQPGIQRCACGLDQSCIDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVIG 767

  Fly   769 DTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVI 833
            ||.....|  .::.|.||||.||....|.::|| ..|::..||....||.|:...|||:..:.|.
  Rat   768 DTNRSSSE--AQFFLRPLRCYGDRNSWNTISFR-TGAALRFPPIRANHSLDVSFYFRTSAPSGVF 829

  Fly   834 F-HATGP-----TDYIKLSLNGGNKLQFQYQAGSGPLGVNV-GTSYHLNDNNWHTVSVERNRKEA 891
            . :..||     ..|:::.||....:.|.:..|:|...:.| ...:..||:.||.|..|.|.|:|
  Rat   830 LENMGGPFCQWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQA 894

  Fly   892 RLVVDGSIKAEVREP----PGPVRA---LHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKE 949
            ||.||       ..|    |.|::.   |.....|.:|:....|..:|||:||:.|||..::| |
  Rat   895 RLRVD-------HRPWVLRPMPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNL-E 951

  Fly   950 YSKRGLYGISTGCVGRCESN--PCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSII 1012
            .......|....|.|.|...  ||.:.|.|:|||..|:|||..:||.||.|..:||....:.:.:
  Rat   952 GRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWM 1016

  Fly  1013 RYEFEGSFRSTIAENIRVGFTTTIP---KGFLLGFSS---------------------------- 1046
            ||..:.:.||. |:......:..:|   .|::.|:.:
  Rat  1017 RYNLQSALRSA-AQEFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYR 1080

  Fly  1047 ----NLTGE------------------------YLTIQISNSGHLRCVFDFGFERQEIIFPKKHF 1083
                |:|||                        |:.:.|...|.|:..:..|..........:..
  Rat  1081 GPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPV 1145

  Fly  1084 GLGQYHDMHFMR--KNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK---------- 1136
            ..||.|.::..|  :|    :.::||.:...|..|.:  ..|:|.::.:.:|:|:
  Rat  1146 TDGQPHSVNITRVYRN----LFIQVDYFPLTEQKFSL--LVDSQLDSPKALYLGRVMETGVIDPE 1204

  Fly  1137 -NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVK-----SLGTQLTEDFCGVEP--VTHPPI 1193
             ....|.||.||:|.|:|:::.|||..|:...|...:     .:..:|:|..||..|  |:..|.
  Rat  1205 IQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPP 1269

  Fly  1194 EIET--RPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYL--HRHKGDYLTHE 1253
            |::.  .||..       ..|::...:.:....::.||||.|:..|:..||  ||:||.|.|:|
  Rat  1270 ELDPWYLPPDF-------PYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNE 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	40/161 (25%)
		FA58C	57..184	CDD:238014	34/138 (25%)
		LamG	192..340	CDD:238058	52/154 (34%)
		LamG	376..514	CDD:238058	40/157 (25%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	40/132 (30%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	33/195 (17%)
		4.1m	1239..1255	CDD:128590	9/17 (53%)
Cntnap1	XP_008766344.1	FA58C	25..175	CDD:214572	40/161 (25%)
		FA58C	37..174	CDD:238014	35/148 (24%)
		LamG	182..337	CDD:238058	52/154 (34%)
		LamG	369..520	CDD:238058	40/157 (25%)
		EGF	551..580	CDD:278437	14/28 (50%)
		FReD	591..>665	CDD:294064	26/76 (34%)
		LamG	794..944	CDD:238058	46/157 (29%)
		LamG	1090..1225	CDD:214598	26/140 (19%)
		4.1m	1311..1329	CDD:128590	9/16 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3028
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	603	1.000	Inparanoid score	I905
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm45876
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880