DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap5l

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_001338473.5	Gene:	cntnap5l / 798019	ZFINID:	ZDB-GENE-140106-102	Length:	1310	Species:	Danio rerio

Alignment Length:	1301	Identity:	382/1301 - (29%)
Similarity:	616/1301 - (47%)	Gaps:	152/1301 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SDYDCNQPLMERAVLTA--TSSL-------TERGPDKARLN---GNAAWTPVENTYNHFLTLDLG 95
            |:|.|.:||     ||:  |||.       ..|.|..|:||   |...|:|.......:|.|||.
Zfish    25 SNYYCEEPL-----LTSLPTSSFRNSSKYSDRRSPHYAKLNRRDGGGGWSPSGEDQQPWLQLDLR 84

  Fly    96 DPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM--FKGNSDGNSIHYNVFEV 158
            |...|..|||.||..:.::|..|.:.|||.|..||.|   ..|..:  |.||||.:::..:....
Zfish    85 DRLKVTSIATQGRWGSSDWVARYQLHYSDSGRTWRPY---RQEDVIWTFTGNSDTDTVVQHKLPH 146

  Fly   159 PIIAQWVRINPTRWHDR--ISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFK 221
            .|..:::|:.|.....|  :.:|:|:|||.|.|:...|:|...:.|...::..::.|:.|..||:
Zfish   147 SIRTRYMRLLPIEGSPRGGMGLRLEVYGCTYKSDVADFDGRSALLYRFNQKSTSTVKDVISLRFR 211

  Fly   222 TAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDL-------GSRVMTSLSVGSLLDDNVWHDVVI 279
            :..|.||:::..|.:||:..|:|:..:::|:|:|       |.| .:|:.:||||||:.||.|.|
Zfish   212 SHQAEGVLVHGEGQRGDFLTLELQRGRLILHLNLDDAKPQSGGR-SSSVMLGSLLDDHHWHSVQI 275

  Fly   280 SRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTN 343
            .|..:.:.|:||......|..|:...|.::.||..||:| ..:.|..:.:||.||:||:.:|..|
Zfish   276 ERFNKHVNFTVDGHTQHFRSLGQEDTLEIDYELSFGGIPLPGKPGTFLHENFHGCIENLNYNGVN 340

  Fly   344 FIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTF-TTRSSFVRLKGYENSQRLNVSFYFRTYE 407
            .|    |..:..:..::|..|..::|.......||| ::..||:.|....:...|:|...|||:.
Zfish   341 VI----DMAKRRKPQIYTVGNVTFSCSESSSVAVTFLSSTGSFLALPADYSMDSLSVRLQFRTWN 401

  Fly   408 ETGVM----LHHDFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQ-FNDGKWHSFVISIEK 467
            :.|::    |.||   ...:.:.|...:.::.|.:....:.....:..| .|||:|||..:.::.
Zfish   402 QEGLLFSVPLSHD---PDPINLLLRLSQARLLLLLSGGPQNSAQVFSGQNLNDGQWHSISVEVKG 463

  Fly   468 NRLILNI-DQRP--MTTTKSMQVATGAQYYIAG-------------GKDKNGFVGCMRLISVDGN 516
            .::.|.: :|:|  |..|...|.......||.|             |:   |:.||.||:.::.:
Zfish   464 EKVSLTVNNQKPATMEITGRSQTPQRTTIYIGGCPLFQSNFNCENPGR---GYQGCFRLLLINNH 525

  Fly   517 YKLPQDWVKGEEVCCGD--DVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCH 579
               |.::::.::...|:  .:..|.|.:.|||.||.|:|.|.|.|:..:|.|:|..|||.||.||
Zfish   526 ---PVNFLQIQQENMGNFSQISFDVCNIQDRCLPNLCEHGGQCIQSWDQFDCNCSGTGYTGATCH 587

  Fly   580 TSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGF 644
            .|....||.|.:...  .|.....:|:||||.|:...|.|....| :|.|.:.|.......:.|.
Zfish   588 NSIYERSCEAFRKTG--SQSSVFTIDLDGSGLLDHAQVNCTVAED-KVWTVVGHDHMRPIDIRGS 649

  Fly   645 QEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQP 709
            .....|.....|..:...:.:|:..|..|.|.:.|.||.||||    :..:..|.|||:.|....
Zfish   650 TPRSPFVLIFNYTISPYHLRSLVTSSEHCQQEVIYRCRKSRLF----DTWDGTPLSWWLDRDGVK 710

  Fly   710 MDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPL 774
            ..||.|.|||.::|.|.:.|.|.|...:||||::...|..|.|.:..|::||:..:..|||..
Zfish   711 RTYWGGFLPGVQQCSCSLDGNCRDMNYFCNCDADQDTWANDTGVLSYKDHLPLSEIAIGDTNR-- 773

  Fly   775 DEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGP 839
            ........:|||||.|:..|.|..:|....:.::.|......|.||.|.|:|:..:.|.....|.
Zfish   774 TNSQAELQIGPLRCYGNRFFWNSASFYQESSYLHFPTLQAELSIDISLFFKTSAFSGVFLENLGV 838

  Fly   840 TDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVR 904
            .|:::|.|:..:.:.|.:..|.||:.:.|.:...|||..||.:..|||.|||.|.|| |:..|:.
Zfish   839 RDFVRLELSSPSTMNFTFDLGDGPVTLTVRSPVALNDRQWHYIRAERNVKEASLQVD-SLPLELT 902

  Fly   905 E-PPGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES 968
            | ||.....|.|:|.|.:|.|...:.|:|||:|||.:||..:||.|.:|. ..|:::||.|.|.|
Zfish   903 EAPPEKPYRLQLSSQLFVGGTASRQRGFVGCLRALTINGVTLDLFERAKT-TPGVNSGCPGHCTS 966

  Fly   969 NP-CLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIR--- 1029
            :. |.|.|.|:|....|:|||..:||.||.|...:..:..|.|.:.|..:..|...:.|..|
Zfish   967 DSVCHNGGRCVEERSSYACDCTQTAFDGPHCRKALAASFESGSSVLYTLQEPFSGILNEEARRSP 1031

  Fly  1030 VGF-----------------TTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEII 1077
            .||                 |..:|.  |:..:..|...|:.:.::::|.|:..:....|::..:
Zfish  1032 AGFHDAEVAKSQEKVSFGFLTRHVPA--LILMAHTLDQNYMAVMLTSNGSLQIRYLMNKEKRTEM 1094

  Fly  1078 FPKKHFGL--GQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK--NE 1138
            |..|...|  |::|.:...||  |..:::::||....:|:.    |..:..:.::.:.:|:  ..
Zfish  1095 FSPKSGSLADGRFHWVKINRK--GQELLVQIDNTITQQYSL----SPGSALSPVRSVILGRIQGS 1153

  Fly  1139 SMTD---------GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIE 1194
            .:||         ||:||:|.|||:...|||...|.:|...|  :| .|....||.  ::.|...
Zfish  1154 DITDKELVQAGLRGFIGCLSSVQFNQATPLKAALQNSPLVTV--IG-HLEASSCGT--ISSPNTL 1213

  Fly  1195 IETR--------------PPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRH 1245
            .:|.              ||...|:..|        :::...:..::|:.|..:.|:| |:|:||
Zfish  1214 SDTHIRSDDSAKSDRGKDPPKKADQNDL--------ALIGGVVAAVVFITLCALAFII-RFLYRH 1269

  Fly  1246 K 1246
            :
Zfish  1270 R 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	49/154 (32%)
		FA58C	57..184	CDD:238014	45/142 (32%)
		LamG	192..340	CDD:238058	50/155 (32%)
		LamG	376..514	CDD:238058	39/159 (25%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	45/119 (38%)
		EGF_CA	966..998	CDD:238011	15/32 (47%)
		Laminin_G_2	1032..1156	CDD:280389	32/153 (21%)
		4.1m	1239..1255	CDD:128590	4/8 (50%)
cntnap5l	XP_001338473.5	FA58C	37..174	CDD:238014	43/139 (31%)
		FA58C	48..175	CDD:214572	41/129 (32%)
		Laminin_G_2	210..339	CDD:280389	45/129 (35%)
		Laminin_G_2	397..525	CDD:280389	31/133 (23%)
		EGF_CA	552..586	CDD:238011	18/33 (55%)
		LamG	799..940	CDD:238058	50/141 (35%)
		EGF_CA	964..997	CDD:238011	15/32 (47%)
		Laminin_G_2	1050..1178	CDD:280389	30/135 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2641
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I703
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm24366
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840