DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap2

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_031759324.1	Gene:	cntnap2 / 780189	XenbaseID:	XB-GENE-956230	Length:	1338	Species:	Xenopus tropicalis

Alignment Length:	1339	Identity:	430/1339 - (32%)
Similarity:	678/1339 - (50%)	Gaps:	166/1339 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CNQPLMERAVL-----TATSSLTERG---PDKARLNGN---AAWTPVENTYNHFLTLDLGDPRMV 100
            |::||    ||     :..||..:.|   |..|:||..   ..|:|:::.:..:|.:|.|:.:.:
Frog    34 CDEPL----VLGLPHPSFRSSSIKSGSYAPGYAKLNKRDEAGGWSPLDSDHYQWLQVDFGNRKQI 94

  Fly   101 RKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWV 165
            |.|||.||..:.::|::|.:.|||.|..|:.| :.......|.||.:.:::..:..:.|:||::|
Frog    95 RSIATQGRYSSSDWVSQYRMLYSDTGRNWKPY-HQDGNIWAFPGNVNSDTVVRHDLQHPVIARYV 158

  Fly   166 RINPTRWHD--RISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGV 228
            ||.|..|::  :|.:|.|||||.|.::.:.|:|...:.|..:.:.:.:.|:.|..:||::.:.||
Frog   159 RIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGLSYRFKNKKMKTLKDVISLKFKSSESEGV 223

  Fly   229 MMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWHDVVISRNQRDII 287
            :.:..|.:|||..|:||..|:||.|:|||...      ||::.||||||:.||.|:|.|:.|:|.
Frog   224 IFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVTSGSLLDDHHWHTVIIERHGRNIN 288

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS 351
            .::||.:...:..|:|..|:|:.||..||:| :.:.....::||.||:|:|.:|..|.
Frog   289 LTLDRHMQHFKTNGDFESLDLDFELTFGGMPFSGKPSSSSRKNFKGCMESINYNGINI------- 346

  Fly   352 TELG-----EGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGV 411
            |:|.     |.|  ...|..:.|......||.|.. :|::.::|..|...|:|||.|||:..:|:
Frog   347 TDLARRKKVEPY--NMANLSFTCVESRSVPVFFNA-TSYLEVRGRPNEDLLSVSFQFRTWNPSGL 408

  Fly   412 MLHHDFYSG-GYLKVFLEFGKVKIDLKV-KDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNI 474
            :|::.|... |.:::.|..|||.:.:.: |.|...|..:.....|||:||...::.::|..||.:
Frog   409 LLYNTFSDELGNVEIDLTEGKVSVHINMTKSKKNRIDISSGSGLNDGQWHEVRLTAKENFAILTV 473

  Fly   475 D---QRPMTTTKSMQVATGAQYYIAGGKD----------KNGFVGCMRLISVD------------ 514
            |   ...:.|...:|..||::|:..|...          ::.|.|||:||.||
Frog   474 DGDEASSVRTNSPLQFQTGSRYFFGGFYSLSNYTDHSLLQHSFQGCMQLIHVDDQLVDLHAVEQG 538

  Fly   515 --GNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAV 577
              |:|.               ::.:|.|.:||||.||.|:|.|.|.|......|:|..|||.||.
Frog   539 KHGSYA---------------NISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYTGAT 588

  Fly   578 CHTSNNPLSCLALKNVQHVQQRVNLN-LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTV 641
            ||.|...|||.|.|   |:.:..:.. :|.||||||.|..|.|....| :|.|||.|.....|.:
Frog   589 CHNSIYELSCEAYK---HLGKSSDWYWIDPDGSGPLGPLKVFCNMTED-KVWTTLFHDLSLQTPI 649

  Fly   642 DGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRH 706
            ...........::.|.|:..||.|:...:..|.|.:|||||.|||.|:|.  ||  |::||:.:.
Frog   650 VAASLDKPVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPD--GN--PYTWWVGKG 710

  Fly   707 NQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTG 771
            |:...||.|:.||.:||.|||...|.|....||||::..:|.:|.|.:..|::|||..|..|||.
Frog   711 NEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDADQRQWRKDAGFLSYKDHLPVSQVVVGDTF 775

  Fly   772 TPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHA 836
            ....|  .:.::.||||.||..:.|..:|....:.::...|....|.||...|:|:..:.|....
Frog   776 RSSSE--AKLSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLEN 838

  Fly   837 TGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKA 901
            .|.||:|||.|....::.|.:..|:||:.:.|.:...|||:.||.|..|||.|||.|.|| .:..
Frog   839 RGKTDFIKLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVD-QLPW 902

  Fly   902 EVREPP--GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG 964
            ::.:.|  |..| |.|.|.|.:||..:.| |::||||:|.:||..:||:|.:|. ..|:..||.|
Frog   903 QLHKAPTQGHTR-LELYSQLFVGAAGDQR-GFLGCIRSLRMNGMTLDLEERAKI-TPGVKPGCSG 964

  Fly   965 RCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIA-- 1025
            .|.|  ..|.|.|.|:|:|:||:|||..:|:.||.|..::|......:.:||.|..:..:.:.
Frog   965 HCTSFGMYCQNGGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVST 1029

  Fly  1026 ------------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFE 1072
                              |.:...|:||.....|| :.|:.:.:||.:.:..||.|:..::.|..
Frog  1030 KETGNIPQSSASDIGLAKEELLFSFSTTKSPCILL-YISSYSQDYLAVLLKASGILQIRYNLGGT 1093

  Fly  1073 RQEI---IFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYI 1134
            :...   |...|:...||.|.::..|  .|..|:.::|:|.|..||  :.:::|.|||..:.:::
Frog  1094 KDPYNIDISDHKNMANGQPHSINITR--SGRNVIFQLDHYPPAVYN--LPSASDTQFNGPKALFL 1154

  Fly  1135 GK--------------------------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKS 1173
            ||                          :...|.||.||:|||||:.|.|||...:.:....|..
Frog  1155 GKVIETQQFGGQSQHQILKETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSNNSQVFI 1219

  Fly  1174 LGTQLTEDFCGVEPVTHPPIEIETRP-----P--PLVDEEKLRKAYNEVDSVLLACLLVILFLLL 1231
            .| :|.|..||..|:|.||:...|.|     |  |..:.:.::...|...:::...:.|::|.:|
Frog  1220 QG-ELVESNCGASPLTIPPMTSNTDPWHSESPEFPNNEGQAIKDGVNRNSAIIGGIIAVVIFTIL 1283

  Fly  1232 ILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHS 1270
            ..:.||| ||:.||||.|.|:|.:||:.||..|.|::::
Frog  1284 CTLVFLI-RYMFRHKGTYHTNEAKGAESADTADAAIINN 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	47/150 (31%)
		FA58C	57..184	CDD:238014	42/139 (30%)
		LamG	192..340	CDD:238058	55/154 (36%)
		LamG	376..514	CDD:238058	45/152 (30%)
		EGF	546..575	CDD:278437	13/28 (46%)
		Laminin_G_2	824..943	CDD:280389	47/120 (39%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	41/152 (27%)
		4.1m	1239..1255	CDD:128590	9/15 (60%)
cntnap2	XP_031759324.1	FA58C	41..179	CDD:238014	41/138 (30%)
		LamG	186..342	CDD:238058	55/155 (35%)
		LamG	374..526	CDD:238058	45/152 (30%)
		EGF	557..588	CDD:394967	14/30 (47%)
		COLFI	603..>631	CDD:413320	11/27 (41%)
		LamG	799..942	CDD:238058	51/145 (35%)
		EGF_CA	966..1000	CDD:238011	16/33 (48%)
		Laminin_G_2	1054..1200	CDD:396680	40/150 (27%)
		4.1m	1289..1307	CDD:128590	11/18 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69159
Inparanoid	1	1.050	656	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm48964
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060