DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and cntnap2

DIOPT Version :10

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_031759324.1 Gene:cntnap2 / 780189 XenbaseID:XB-GENE-956230 Length:1338 Species:Xenopus tropicalis


Alignment Length:1339 Identity:430/1339 - (32%)
Similarity:678/1339 - (50%) Gaps:166/1339 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 CNQPLMERAVL-----TATSSLTERG---PDKARLNGN---AAWTPVENTYNHFLTLDLGDPRMV 100
            |::||    ||     :..||..:.|   |..|:||..   ..|:|:::.:..:|.:|.|:.:.:
 Frog    34 CDEPL----VLGLPHPSFRSSSIKSGSYAPGYAKLNKRDEAGGWSPLDSDHYQWLQVDFGNRKQI 94

  Fly   101 RKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWV 165
            |.|||.||..:.::|::|.:.|||.|..|:.| :.......|.||.:.:::..:..:.|:||::|
 Frog    95 RSIATQGRYSSSDWVSQYRMLYSDTGRNWKPY-HQDGNIWAFPGNVNSDTVVRHDLQHPVIARYV 158

  Fly   166 RINPTRWHD--RISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGV 228
            ||.|..|::  :|.:|.|||||.|.::.:.|:|...:.|..:.:.:.:.|:.|..:||::.:.||
 Frog   159 RIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGLSYRFKNKKMKTLKDVISLKFKSSESEGV 223

  Fly   229 MMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWHDVVISRNQRDII 287
            :.:..|.:|||..|:||..|:||.|:|||...      ||::.||||||:.||.|:|.|:.|:|.
 Frog   224 IFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVTSGSLLDDHHWHTVIIERHGRNIN 288

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS 351
            .::||.:...:..|:|..|:|:.||..||:| :.:.....::||.||:|:|.:|..|.       
 Frog   289 LTLDRHMQHFKTNGDFESLDLDFELTFGGMPFSGKPSSSSRKNFKGCMESINYNGINI------- 346

  Fly   352 TELG-----EGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGV 411
            |:|.     |.|  ...|..:.|......||.|.. :|::.::|..|...|:|||.|||:..:|:
 Frog   347 TDLARRKKVEPY--NMANLSFTCVESRSVPVFFNA-TSYLEVRGRPNEDLLSVSFQFRTWNPSGL 408

  Fly   412 MLHHDFYSG-GYLKVFLEFGKVKIDLKV-KDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNI 474
            :|::.|... |.:::.|..|||.:.:.: |.|...|..:.....|||:||...::.::|..||.:
 Frog   409 LLYNTFSDELGNVEIDLTEGKVSVHINMTKSKKNRIDISSGSGLNDGQWHEVRLTAKENFAILTV 473

  Fly   475 D---QRPMTTTKSMQVATGAQYYIAGGKD----------KNGFVGCMRLISVD------------ 514
            |   ...:.|...:|..||::|:..|...          ::.|.|||:||.||            
 Frog   474 DGDEASSVRTNSPLQFQTGSRYFFGGFYSLSNYTDHSLLQHSFQGCMQLIHVDDQLVDLHAVEQG 538

  Fly   515 --GNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAV 577
              |:|.               ::.:|.|.:||||.||.|:|.|.|.|......|:|..|||.||.
 Frog   539 KHGSYA---------------NISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYTGAT 588

  Fly   578 CHTSNNPLSCLALKNVQHVQQRVNLN-LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTV 641
            ||.|...|||.|.|   |:.:..:.. :|.||||||.|..|.|....| :|.|||.|.....|.:
 Frog   589 CHNSIYELSCEAYK---HLGKSSDWYWIDPDGSGPLGPLKVFCNMTED-KVWTTLFHDLSLQTPI 649

  Fly   642 DGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRH 706
            ...........::.|.|:..||.|:...:..|.|.:|||||.|||.|:|.  ||  |::||:.:.
 Frog   650 VAASLDKPVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPD--GN--PYTWWVGKG 710

  Fly   707 NQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTG 771
            |:...||.|:.||.:||.|||...|.|....||||::..:|.:|.|.:..|::|||..|..|||.
 Frog   711 NEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDADQRQWRKDAGFLSYKDHLPVSQVVVGDTF 775

  Fly   772 TPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHA 836
            ....|  .:.::.||||.||..:.|..:|....:.::...|....|.||...|:|:..:.|....
 Frog   776 RSSSE--AKLSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLEN 838

  Fly   837 TGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKA 901
            .|.||:|||.|....::.|.:..|:||:.:.|.:...|||:.||.|..|||.|||.|.|| .:..
 Frog   839 RGKTDFIKLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVD-QLPW 902

  Fly   902 EVREPP--GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG 964
            ::.:.|  |..| |.|.|.|.:||..:.| |::||||:|.:||..:||:|.:|. ..|:..||.|
 Frog   903 QLHKAPTQGHTR-LELYSQLFVGAAGDQR-GFLGCIRSLRMNGMTLDLEERAKI-TPGVKPGCSG 964

  Fly   965 RCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIA-- 1025
            .|.|  ..|.|.|.|:|:|:||:|||..:|:.||.|..::|......:.:||.|..:..:.:.  
 Frog   965 HCTSFGMYCQNGGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVST 1029

  Fly  1026 ------------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFE 1072
                              |.:...|:||.....|| :.|:.:.:||.:.:..||.|:..::.|..
 Frog  1030 KETGNIPQSSASDIGLAKEELLFSFSTTKSPCILL-YISSYSQDYLAVLLKASGILQIRYNLGGT 1093

  Fly  1073 RQEI---IFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYI 1134
            :...   |...|:...||.|.::..|  .|..|:.::|:|.|..||  :.:::|.|||..:.:::
 Frog  1094 KDPYNIDISDHKNMANGQPHSINITR--SGRNVIFQLDHYPPAVYN--LPSASDTQFNGPKALFL 1154

  Fly  1135 GK--------------------------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKS 1173
            ||                          :...|.||.||:|||||:.|.|||...:.:....|..
 Frog  1155 GKVIETQQFGGQSQHQILKETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSNNSQVFI 1219

  Fly  1174 LGTQLTEDFCGVEPVTHPPIEIETRP-----P--PLVDEEKLRKAYNEVDSVLLACLLVILFLLL 1231
            .| :|.|..||..|:|.||:...|.|     |  |..:.:.::...|...:::...:.|::|.:|
 Frog  1220 QG-ELVESNCGASPLTIPPMTSNTDPWHSESPEFPNNEGQAIKDGVNRNSAIIGGIIAVVIFTIL 1283

  Fly  1232 ILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHS 1270
            ..:.||| ||:.||||.|.|:|.:||:.||..|.|::::
 Frog  1284 CTLVFLI-RYMFRHKGTYHTNEAKGAESADTADAAIINN 1321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 57..184 CDD:238014 42/139 (30%)
LamG 192..340 CDD:238058 55/154 (36%)
LamG 376..514 CDD:238058 45/152 (30%)
EGF 546..575 CDD:394967 13/28 (46%)
LamG 819..943 CDD:214598 49/125 (39%)
EGF_CA 966..998 CDD:238011 16/33 (48%)
Laminin_G_2 1032..1156 CDD:460494 41/152 (27%)
4.1m 1239..1255 CDD:128590 9/15 (60%)
cntnap2XP_031759324.1 FA58C 41..179 CDD:238014 41/138 (30%)
LamG 186..342 CDD:238058 55/155 (35%)
LamG 374..526 CDD:238058 45/152 (30%)
EGF 557..588 CDD:394967 14/30 (47%)
GGGWT_bact 597..633 CDD:468872 15/38 (39%)
LamG 799..942 CDD:238058 51/145 (35%)
EGF_CA 966..1000 CDD:238011 16/33 (48%)
Laminin_G_2 1054..1200 CDD:460494 40/150 (27%)
4.1m 1289..1307 CDD:128590 11/18 (61%)

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