DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and CNTNAP3B

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001188309.2	Gene:	CNTNAP3B / 728577	HGNCID:	32035	Length:	1288	Species:	Homo sapiens

Alignment Length:	1296	Identity:	409/1296 - (31%)
Similarity:	634/1296 - (48%)	Gaps:	150/1296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DCNQPL---MERAVLTATSSL-TERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKI 103
            ||:.||   :.|:..:::|.| :..||..:|||   |...|||:.:....:|.:|||:...|..:
Human    30 DCDSPLASALPRSSFSSSSELSSSHGPGFSRLNRRDGAGGWTPLVSNKYQWLQIDLGERMEVTAV 94

  Fly   104 ATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM--FKGNSDGNS-IHYNVFEVPIIAQWV 165
            ||.|...:.::||.|::.:||.|..|:.|   ..|..:  |.||::.:| :||.: :.|..|:::
Human    95 ATQGGYGSSDWVTSYLLMFSDGGRNWKQY---RREESIWGFPGNTNADSVVHYRL-QPPFEARFL 155

  Fly   166 RINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGV 228
            |..|..|:  .||.||:|:|||.|.||.:||:|...:.|.|.::|:...::.|..:||...:||:
Human   156 RFLPLAWNPRGRIGMRIEVYGCAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGI 220

  Fly   229 MMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTS------LSVGSLLDDNVWHDVVISRNQRDII 287
            :::..|..|::..|:|...|:|..|:.|:..:.|      |::||||||..||.|:|......:.
Human   221 LLHREGQHGNHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVN 285

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGGV--PNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKD 350
            |:||:.....:.:|:.:.|:||.|:..||:  |. :.....:::|.|||||:|:|..       |
Human   286 FTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPG-RSRAFTRKSFHGCLENLYYNGV-------D 342

  Fly   351 STELGEGY---LFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVM 412
            .|||.:.:   :....|..::||.|...||||.:..|::.|.|.....:::|:|.|||:...|.:
Human   343 VTELAKKHKPQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHL 407

  Fly   413 LHHDFYSG-GYLKVFLEFGKVKIDL-KVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNID 475
            |..:...| |...:||:.||:|:.| :.....|.:.....  .|||:|||...|.:.:.:.:.:|
Human   408 LFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVVD 470

  Fly   476 Q----RPMTTTKSMQVATGAQYYIAG--GKDK--------NGFVGCMRLISVDGNYKLPQDWVKG 526
            .    :|:.   ::.:.:|..||..|  |...        .||.||:|||:: |:..:....|:.
Human   471 DDTAVQPLV---AVLIDSGDTYYFGGCLGNSSGSGCKSPLGGFQGCLRLITI-GDKAVDPILVQQ 531

  Fly   527 EEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALK 591
            ..:....|:.:|:|.:.|||.|:.|:|.|.|.|:...|.|||..|||.|..||:|....||.|.|
Human   532 GALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHK 596

  Fly   592 NVQHVQQRVNLN----LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQ 652
            :      |.|.:    :|.||||||.||.|.|...:|. ..|.:.|......|:.|  .|.....
Human   597 H------RGNPSGLYYIDADGSGPLGPFLVYCNMTADS-AWTVVRHGGPDAVTLRG--APSGHPL 652

  Fly   653 SIM---YDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWA 714
            |.:   |.|...|:.|.:|.:..|.|||:..|.::|  ...|..|.  |.|||:.|.|:....|.
Human   653 SAVSFAYAAGAGQLRAAVNLAERCEQRLALRCGTAR--RPDSRDGT--PLSWWVGRTNETHTSWG 713

  Fly   715 GALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMG 779
            |:||.::||.||:.|.|.|...:||||:...||..|...:.:||:|||..:...|||.|..|  .
Human   714 GSLPDAQKCTCGLEGNCIDSQYYCNCDAGQNEWTSDTIVLSQKEHLPVTQIVMTDTGQPHSE--A 776

  Fly   780 RYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIK 844
            .||||||.|.||..|.|..:|....:.::.|.|....:.|:...|:||..:.|.....|.||:|:
Human   777 DYTLGPLLCRGDKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIR 841

  Fly   845 LSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPP-- 907
            :.|....::.|.:..|:||..|.|.:....|||.||.|..|||.|.|.|.|| .:..:::..|
Human   842 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD-QLPQKMQPAPAD 905

  Fly   908 GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLY--GISTGCVGRCES-- 968
            |.|| |.|.|.|.||.|...:.|::||||:|.|||..:||:|   |...  |:..||.|.|.:
Human   906 GHVR-LQLNSQLFIGGTATRQRGFLGCIRSLQLNGVALDLEE---RATVTPGVEPGCAGHCSTYG 966

  Fly   969 NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAEN------ 1027
            :.|.|.|.|.|:..|.:|||.:||:.||.|::||.....:.|.:.|.|:..:  |::||
Human   967 HLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHY--TLSENSSSLVS 1029

  Fly  1028 ------------IRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQE----I 1076
                        |.:.|.||.....|| :.|:...|||::.::|:|.|:  ..:..:|.:    .
Human  1030 SLHRDVTLTREMITLSFRTTRTPSLLL-YVSSFYEEYLSVILANNGSLQ--IRYKLDRHQNPDAF 1091

  Fly  1077 IFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIK----ASADAQFNNIQYMYIGK- 1136
            .|..|:...||.|.:...|:   ..||:       ||.|...|    .|:..:||.::.:.:||
Human  1092 TFDFKNMADGQLHQVKINRE---EAVVM-------VEVNQSAKKQVILSSGTEFNAVKSLILGKV 1146

  Fly  1137 ----------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHP 1191
                      ..:.|.||.||:|.|:|....|||...:.:.|..|...|.......|.....:..
Human  1147 LEAAGADPDTRRAATSGFTGCLSAVRFGCAAPLKAALRPSGPSRVTVRGHVAPMARCAAGAASGS 1211

  Fly  1192 PI-EIET-------RPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHR 1244
            |. |:..       |..|:.:.|.|..|.....:|:...:.|.:|:||.:....|..|..|
Human  1212 PARELAPRLAGGAGRSGPVDEGEPLVNADRRDSAVIGGVIAVEIFILLCITAIAIRIYQQR 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	50/150 (33%)
		FA58C	57..184	CDD:238014	44/135 (33%)
		LamG	192..340	CDD:238058	49/155 (32%)
		LamG	376..514	CDD:238058	44/153 (29%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	48/120 (40%)
		EGF_CA	966..998	CDD:238011	14/33 (42%)
		Laminin_G_2	1032..1156	CDD:280389	38/142 (27%)
		4.1m	1239..1255	CDD:128590	2/6 (33%)
CNTNAP3B	NP_001188309.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..61		9/30 (30%)
		FA58C	54..176	CDD:238014	42/125 (34%)
		Laminin_G_2	212..341	CDD:308045	43/129 (33%)
		LamG	371..519	CDD:238058	44/152 (29%)
		EGF	551..582	CDD:306513	15/30 (50%)
		FReD	590..>635	CDD:294064	19/51 (37%)
		LamG	794..938	CDD:238058	50/145 (34%)
		Laminin_G_2	1046..1174	CDD:308045	37/140 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1215..1236		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2858
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	667	1.000	Inparanoid score	I757
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm41743
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880