DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap2

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001004357.2	Gene:	Cntnap2 / 66797	MGIID:	1914047	Length:	1332	Species:	Mus musculus

Alignment Length:	1330	Identity:	436/1330 - (32%)
Similarity:	682/1330 - (51%)	Gaps:	155/1330 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CNQPL---MERAVLTATSSLTER-GPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIA 104
            |::||   :.....:::|||:.. .|..|::|   |...|:|.::.:..:|.:|.|:.:.:..||
Mouse    35 CDEPLISGLPHVSFSSSSSLSSSYAPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIA 99

  Fly   105 TMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINP 169
            |.||..:.::||:|.:.|||.|..|:.| :.......|.||.:.:|:..:..:..::|::||:.|
Mouse   100 TQGRYSSSDWVTQYRMLYSDTGRNWKPY-HQDGNIWAFPGNVNSDSVVRHDLQHAVVARYVRVVP 163

  Fly   170 TRWH--DRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYS 232
            ..|:  ..|.:|.|:|||.|.::.:.|:|.|::.|..|.:.:.:.|:.|..:|||:.:.||:::.
Mouse   164 LDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRNKKMKTLKDVIALKFKTSESEGVLLHG 228

  Fly   233 RGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWHDVVISRNQRDIIFSVD 291
            .|.||||..|:||..|:||:|:|||..:      ||::.||||||:.||.|:|.|..|.|..::|
Mouse   229 EGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLD 293

  Fly   292 RVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFI----RVMKDS 351
            |.:...|..|||..|:|:.|:..||:| :.:.....::||.||:|:|.:|..|..    |...:.
Mouse   294 RSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNRKNFKGCMESINYNGVNITDLARRKKLEP 358

  Fly   352 TELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHD 416
            :.:|        |..::|..|...||.|.. :|::.:.|..|....:|||.|||:..:|::|...
Mouse   359 SNMG--------NLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQFRTWNPSGLLLFSH 414

  Fly   417 FYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQ-----------FNDGKWHSFVISIEKNRL 470
            |..        ..|.|:||| |:.|..:.::|...:           .|||:||......::|..
Mouse   415 FAD--------NLGNVEIDL-VESKVGVHINNTQTKTSQIDISSGSGLNDGQWHEVRFLAKENFA 470

  Fly   471 ILNID---QRPMTTTKSMQVATGAQYYIAGGKD----------KNGFVGCMRLISVDGN------ 516
            :|.||   ...:.|...:||.||.:|:..|..:          :..|.|||:||.||..
Mouse   471 VLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYE 535

  Fly   517 --YKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCH 579
              ::.|..:.         :|.:|.|.:||||.||.|:|.|.|.|....|.|.|..|||:||.||
Mouse   536 VAHRKPGSFA---------NVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCH 591

  Fly   580 TSNNPLSCLALKNVQHVQQRVNLN-LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDG 643
            .|....||.|.|   |:.|..|.. :|.||||||.|..|.|....| :|.|.:||..:..|||.|
Mouse   592 NSIYEPSCEAYK---HLGQTSNYYWIDPDGSGPLGPLKVYCNMTED-KVWTIVSHDLQMQTTVVG 652

  Fly   644 FQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQ 708
            :.........::|.|:..||.|:.:.:..|.|.:||.||.|||.|:|..:    |::||:.:.|:
Mouse   653 YNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDGS----PYTWWVGKANE 713

  Fly   709 PMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTP 773
            ...||.|:.||.:||.|||...|.||..:||||::..:|.:|.|.:..|::|||..|..|||...
Mouse   714 KHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQ 778

  Fly   774 LDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATG 838
            ..|  .:.::|||||:||..:.|..:|....:.::...|....|.||...|:|.....|.....|
Mouse   779 GSE--AKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLG 841

  Fly   839 PTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEV 903
            .||:|||.|....::.|.:..|:||:.:.|.:...|||:.||.|:.|||.|:|.|.|| .:..::
Mouse   842 NTDFIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVD-RLPQQI 905

  Fly   904 REPP--GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRC 966
            |:.|  |..| |.|.|.|.:|.... :.|::||||:|.:||..:||:|.:| ...|..:||.|.|
Mouse   906 RKAPTEGHTR-LELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAK-VTSGFKSGCSGHC 967

  Fly   967 ES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFE---------GSF 1020
            .|  ..|.|.|.|||:|.||||||..:|:.|..|..::|........:||.|:         ||.
Mouse   968 TSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSR 1032

  Fly  1021 RSTIA------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFER 1073
            ....|            |.|...|:||.....|| :.|:||.::|.:.:..:|:|:..::.|..|
Mouse  1033 AENSADQQQHLAPDLAQEQIHFSFSTTKAPCILL-YVSSLTTDFLAVLVKPTGNLQIRYNLGGTR 1096

  Fly  1074 QEIIFPKKHFGL--GQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK 1136
            :.......|..:  ||.|.::..|..  .|::||:|:|..|.|:  :.:|:|..||:.:.:::||
Mouse  1097 EPFNIDVDHRNMANGQPHSVNITRHE--RTIILKLDHYPAVGYH--LPSSSDTLFNSPKSLFLGK 1157

  Fly  1137 -----------NESMTDGFVGCVSRVQFDDIYPLKLMFQQ-NPPKNVKSLGTQLTEDFCGVEPVT 1189
                       ::..|.||.||:|||||:.|.|||...:| |...:|...| :|.|..||..|:|
Mouse  1158 VIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQG-ELVESNCGASPLT 1221

  Fly  1190 HPPIEIETRPPPL--VDE------------EKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGR 1240
            ..|:...|.|..|  :|.            :.:|...|...:::...:.|::|.:|..:.||| |
Mouse  1222 LSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLI-R 1285

  Fly  1241 YLHRHKGDYLTHEDQGADGADDPDDAVLHS 1270
            |:.||||.|.|:|.:||:.|:..|.|::::
Mouse  1286 YMFRHKGTYHTNEAKGAESAESADAAIMNN 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	42/146 (29%)
		FA58C	57..184	CDD:238014	38/132 (29%)
		LamG	192..340	CDD:238058	60/154 (39%)
		LamG	376..514	CDD:238058	45/161 (28%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	45/120 (38%)
		EGF_CA	966..998	CDD:238011	17/33 (52%)
		Laminin_G_2	1032..1156	CDD:280389	41/136 (30%)
		4.1m	1239..1255	CDD:128590	9/15 (60%)
Cntnap2	NP_001004357.2	FA58C	34..181	CDD:214572	42/146 (29%)
		FA58C	58..180	CDD:238014	35/122 (29%)
		Laminin_G_2	216..345	CDD:280389	54/128 (42%)
		LamG	375..527	CDD:238058	45/161 (28%)
		EGF_CA	555..590	CDD:238011	19/34 (56%)
		COLFI	609..>632	CDD:295304	11/22 (50%)
		LamG	800..943	CDD:238058	49/145 (34%)
		EGF	967..>992	CDD:278437	14/24 (58%)
		LamG	1051..1187	CDD:214598	42/140 (30%)
		4.1m	1283..1301	CDD:128590	11/18 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2736
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69159
Inparanoid	1	1.050	671	1.000	Inparanoid score	I733
Isobase	1	0.950	-	0	Normalized mean entropy	S6555
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm43791
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3775
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820