DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap5a

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001357942.1	Gene:	Cntnap5a / 636808	MGIID:	3643623	Length:	1305	Species:	Mus musculus

Alignment Length:	1331	Identity:	426/1331 - (32%)
Similarity:	651/1331 - (48%)	Gaps:	143/1331 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTE--R 66
            ||.|:             :|.||.:|:..:...|     ::|:|:.||.....|.|.||.::  .
Mouse     5 PRLNS-------------VLTLVLSGLWHLGLTA-----TNYNCDDPLSNFLSLKAFSSSSDITG 51

  Fly    67 GPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEF 128
            ....|:||   |...|:|.::....:|.:||.:...:..:||.||..:.::||.|.:.:||.|..
Mouse    52 SSSSAQLNWRMGTGGWSPADSNAQQWLQIDLQNRVEITAVATQGRYGSSDWVTSYRLMFSDTGHN 116

  Fly   129 WRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRW--HDRISMRVELYGCDYISEN 191
            |:.| |.......|.||.:.:|:.::.....:.|::||..|..|  :.:|.||||.|||.|.|:.
Mouse   117 WQPY-NQEDSIWTFVGNMNSDSVVHHKLLHSVRARFVRFVPLEWNPNGKIGMRVEAYGCSYRSDV 180

  Fly   192 LYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDL- 255
            ..|:|...:.|...::.:::.|:.|..:||:...:||:.:..|.:||:..|:|:..::.|.|:|
Mouse   181 ADFDGRSSLLYRFNQKTMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALYLNLD 245

  Fly   256 GSRVMTSLSV-----GSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLG 315
            .|:...|.:|     ||||||..||.|::.|..:...|:||......|.:|:...|:::.||..|
Mouse   246 DSKARLSSTVPLVILGSLLDDQHWHSVLLERVGKQANFTVDMNTQHFRTKGDTDSLDIDYELSFG 310

  Fly   316 GVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTF 379
            |:| ..:.|..:::||.||:||:|:|..|.|    |..:..:..:::..|..::|..|.|.|:||
Mouse   311 GIPVPSKPGTFLKKNFHGCIENLYYNGVNII----DLAKRRKHQIYSVGNVTFSCSEPQIVPITF 371

  Fly   380 -TTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSG-GYLKVFLEFGKVKIDLKVKDKA 442
             .:|||::.|.|......|:|||.|||:.|.|::|..:...| |.|.:.||.|.::  |.:|..|
Mouse   372 INSRSSYLMLPGTPQIDGLSVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLR--LLIKKVA 434

  Fly   443 R---IILDNYDDQFNDGKWHSFVISIEKNRLILNIDQ---RPMTTTKSMQVATGAQYYIAGGKDK 501
            |   .||..  ...|||.|||..|:..:||:.|.:|.   .|...|..:|:.:|..||..|..|.
Mouse   435 RHGTEILTG--SGLNDGLWHSVSINARRNRVTLTLDNDAASPAPDTSRIQIYSGKSYYFGGCPDN 497

  Fly   502 ----------NGFVGCMRLISVDGNYKLPQDWVKGEEVCCG--DDVVVDACQMIDRCNPNPCQHK 554
                      ..|.||||||.:|..   |:|.:..::...|  .|:.:|.|.:.|||.||.|:|.
Mouse   498 LTDSQCLNPIKAFQGCMRLIFIDNQ---PKDLISVQQGSLGSFSDLHIDLCSIKDRCLPNYCEHG 559

  Fly   555 GLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTC 619
            |.|.|....|:|:|..|||.||.||.|....||...::..|...  ...:|.||||||.|..|.|
Mouse   560 GHCDQTWTTFYCNCSGTGYTGATCHDSIYEQSCEVYRHRGHTAG--FFYVDSDGSGPLGPLQVYC 622

  Fly   620 EFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSS 684
            ....| ::..|:.|:....|.|.|......:..::.|..:..|:|||::.|..|.|.:.|.||.|
Mouse   623 NITED-KIWMTVQHNNTELTRVQGSSPENPYSMTLNYGGSMEQLEALIDGSEYCEQEVIYHCRRS 686

  Fly   685 RLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWME 749
            ||.|:|..|    ||:|||.|..:...||.||:||.::|.||:...|.|...:||||::..||..
Mouse   687 RLLNTPDGA----PFTWWIGRSTERHPYWGGAVPGVQQCGCGLEESCLDSRHFCNCDADIDEWAN 747

  Fly   750 DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDM 814
            |.|....|::|||..:...||.....|...|  :|||||.||..|.|.|:|....:.::.|.|..
Mouse   748 DTGLFSFKDHLPVTQIIIMDTNRTNSEAAWR--IGPLRCYGDRHFWNAVSFSTEASYLHFPTFHT 810

  Fly   815 GHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNW 879
            ..|.||...|:||..:.|.....|..|:.:|.::..:::.|....|:||:.:.|.:.|.||||.|
Mouse   811 EFSADISFFFKTTALSGVFLENLGIKDFFRLEMSSPSEVTFAIDVGNGPIELLVQSPYPLNDNQW 875

  Fly   880 HTVSVERNRKEARLVVDGSIKAEVREPP--GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNG 942
            |.:..|.|.||..|.|| ::...:||..  |..| |.|.|.|.:|.|:..:.|::||||:|||||
Mouse   876 HYIRAETNLKETSLQVD-NLPQSMREASEGGHFR-LQLNSQLFVGGTSSRQKGFLGCIRSLLLNG 938

  Fly   943 KMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVN 1005
            ..|||:|.:| ...|:..||.|.|.|  :.|.|.|.|:|::.||||||..|.::||.|..||...
Mouse   939 HKVDLEERAK-VTSGVRPGCPGHCSSYGSNCHNGGKCVEKHTGYSCDCTNSPYEGPFCRKEISAL 1002

  Fly  1006 LRSSSIIRYEFEGSFRST----------------IAENIRVGFTTTIPKGFL--LGFSSNLTGEY 1052
            ..|.:.:.|.|:..:..|                ..|.|.:.|.||.....|  |.|||.   .:
Mouse  1003 FDSGTSVTYMFQEPYPVTKNTSLSSSAIYTDLAPFKETIMLSFMTTQAPTLLLYLNFSSQ---NF 1064

  Fly  1053 LTIQISNSGHLRCVFDFGFERQEII-FPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF 1116
            |.|.:|.:|.|:..:....:...:. ...::....:.|.:...|  .|..:.:::|. :...|:|
Mouse  1065 LAILLSRNGSLQVRYRLSKDESHVFNMDTENLANRRVHQVKISR--DGPELSIQMDQ-QLFSYSF 1126

  Fly  1117 DIKASADAQFNNIQYMYIGKNESMTD-----------GFVGCVSRVQFDDIYPLK--LMFQQNPP 1168
                |.:.:|..::.:.:||.....|           |||||:|.||::.|.|||  |......|
Mouse  1127 ----SPEVEFRTLRSLVLGKVTETLDLDPEVARANTLGFVGCLSSVQYNHIAPLKAALRHASIAP 1187

  Fly  1169 KNVKSLGTQLTEDFCG------VEPVT--HPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLV 1225
            ..|:.   .|||..||      |..||  |   .:........|.|.|:.|.....:|:...:.|
Mouse  1188 VTVQK---TLTESSCGSMVDSDVNAVTTVH---SLSDSFGKTDDHEPLQNAVRSDSAVIGGVIAV 1246

  Fly  1226 ILFLLLILMFFLIG---RYLHRHKGDYLTHE 1253
            :.|    :.|.:||   |:|::||..:.|::
Mouse  1247 VTF----ITFCVIGIMTRFLYQHKQSHRTNQ 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	44/145 (30%)
		FA58C	57..184	CDD:238014	40/133 (30%)
		LamG	192..340	CDD:238058	49/154 (32%)
		LamG	376..514	CDD:238058	56/155 (36%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	45/120 (38%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	32/137 (23%)
		4.1m	1239..1255	CDD:128590	6/18 (33%)
Cntnap5a	NP_001357942.1	FA58C	56..173	CDD:238014	36/117 (31%)
		LamG	205..338	CDD:214598	46/132 (35%)
		Laminin_G_2	396..519	CDD:366983	44/126 (35%)
		EGF	551..582	CDD:333761	15/30 (50%)
		LamG	793..937	CDD:238058	50/145 (34%)
		EGF_CA	961..995	CDD:238011	16/33 (48%)
		Laminin_G_2	1045..1170	CDD:366983	31/134 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2736
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I733
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48725
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm43791
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830