Protein Alignment Nrx-IV and Cntnap5c

DIOPT Version :10

• Sequence 1: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_006524804.1
• Gene: Cntnap5c / 620292
• MGIID: 3646013
• Length: 1306
• Species: Mus musculus
• Alignment Length: 1311
• Identity: 410/1311 - (31%)
• Similarity: 658/1311 - (50%)
• Gaps: 120/1311 - (9%)

  Fly    43 SDYDCNQPL---MERAVLTATSSLTERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVR 101
            ::|:|:.||   :.....:::|.||.|. ..|:||   |...|:|.::....:|.:|||:...:.
Mouse    26 TNYNCDDPLTSFLSLRAFSSSSDLTGRS-SPAQLNWRMGTGGWSPADSNAQQWLQMDLGNRVEIT 89

  Fly   102 KIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM--FKGNSDGNSIHYNVFEVPIIAQW 164
            .:||.||..:.::||.|.:.:||.|..|:.|   |.|..:  |.||.:.||:.::.....:.|::
Mouse    90 AVATQGRYGSSDWVTSYRLMFSDTGHNWQQY---TQEGSIWRFVGNMNANSVVHHKLLNSVRARF 151

  Fly   165 VRINPTRW--HDRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANG 227
            ||..|..|  :.:|.||||:|||.|.|:...|:|...:.|...::.:::.|:.|..:||:...:|
Mouse   152 VRFVPLEWNPNGKIGMRVEVYGCSYRSDVADFDGWSSLLYRFNQKTMSTLKDVISLKFKSIQRDG 216

  Fly   228 VMMYSRGTQGDYYALQLKDNKMVLNLDL-GSRVMTS-----LSVGSLLDDNVWHDVVISRNQRDI 286
            |:.:..|.:||:..|:|::.::.|.|:| .|:...|     .::||||||..||.|::.|..:..
Mouse   217 VLFHGEGQRGDHITLELQNGRLALYLNLDDSKAQVSSTAPLATLGSLLDDQHWHSVLLERVGKQA 281

  Fly   287 IFSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKD 350
            .|:||:.....:.:||...|:::.||..||:| ..:.|..:::||.||:||:|:|..|.|    |
Mouse   282 NFTVDKNTQHFQTKGETDALDIDYELSFGGIPVPSKPGTFLKKNFHGCIENLYYNGVNII----D 342

  Fly   351 STELGEGYLFTRVNTIYACPSPPIYPVTF-TTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLH 414
            ..:..:..:::..|..::|..|...|:|| .:|||::.|.|......|:|||.|||:.|.|::|.
Mouse   343 LAKRRKHQIYSVGNVTFSCSEPQTVPITFVNSRSSYLLLTGTPQIDGLSVSFQFRTWNEDGLLLS 407

  Fly   415 HDFYSG-GYLKVFLEFGKVKIDLKVKDKARIILDNYDDQ-FNDGKWHSFVISIEKNRLILNIDQR 477
            .:...| |.|.:.||.|.::  |.:|..||...:.:... .|||.|||..||..:||:.|.:|..
Mouse   408 TELSEGSGTLLLILEGGTLR--LLIKKLARHGTEIFTGSGLNDGMWHSVSISARRNRVTLTLDND 470

  Fly   478 PMT---TTKSMQVATGAQYYIAGGKDK----------NGFVGCMRLISVDGNYKLPQDWVKGEEV 529
            ..:   .|..:|:.:|..||..|..|.          ..|.||||||.:|..   |:|.:..::.
Mouse   471 AASLPPDTSWLQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQ---PKDLISVQQG 532

  Fly   530 CCG--DDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKN 592
            ..|  .|:.:|.|.:.|||.||.|:|.|.|.|....|:|:|..|||.||.||.|....||...::
Mouse   533 SLGSFSDLHIDLCSIKDRCLPNYCEHGGQCAQTWTNFYCNCSDTGYTGATCHDSIYEQSCEVYRH 597

  Fly   593 VQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYD 657
            .....:  ...:|.||||||.|..|.|....| ::..|:.|:....|.|.|......:..::.|.
Mouse   598 RGKTAE--FFYVDSDGSGPLGPLQVFCNITED-KIWMTVQHNNTGLTWVQGSNPEKPYAMTLNYG 659

  Fly   658 ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRK 722
            .:..|:|||::.|..|.|.::|.|:.|||.|:|...    ||:|||.|.|:...||.|:|||.::
Mouse   660 GSLEQLEALIDGSEHCEQEVTYYCKRSRLLNTPDGV----PFTWWIGRSNEKHPYWGGSLPGVQQ 720

  Fly   723 CECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLR 787
            |.||:...|.|...:||||:::.||..|.|.:..|::|||..:...||.....|...|  :||||
Mouse   721 CGCGLEESCLDIRHFCNCDADTDEWTNDTGYLSFKDHLPVTQIIITDTNRSKSEAAWR--IGPLR 783

  Fly   788 CEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNK 852
            |.||..|.|.|:|....:.::.|.|.:..|.||:..|:||..:.|.....|..|:::|.::..::
Mouse   784 CYGDRHFWNAVSFSTEASFLHFPTFRVEFSADIFFFFKTTALSGVFLEILGIKDFLRLEMSSPSE 848

  Fly   853 LQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVRE--PPGPVRALHL 915
            :.|....|:||:.:.|.:.|.||||.||.:..|||.||..|.|| ::...:||  ..|..: ..|
Mouse   849 VIFAIDVGNGPIDLLVQSPYPLNDNQWHYIRAERNLKETSLQVD-NLPQSMREASEEGHFQ-FQL 911

  Fly   916 TSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCI 978
            .|.|.:|..:..:.|:.||||:|.|||:.:||:|.:| ...|:..||.|.|.|  ..|.|.|.|:
Mouse   912 NSQLFVGGKSSRQKGFFGCIRSLHLNGQNIDLEERAK-VTSGVRPGCPGHCSSYGRNCQNGGKCV 975

  Fly   979 ERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIRVG--FTTTIPK--- 1038
            |::.||||||..|.::||.|..||.....|.:.:.|.|:..:..|...|:...  :|.|.|.
Mouse   976 EKHIGYSCDCTNSPYEGPFCQKEISALFDSDTSVTYMFQEPYSVTKNTNLSSSAIYTDTAPSKEI 1040

  Fly  1039 ---GFL----------LGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEII-FPKKHFGLGQYH 1089
               .|:          |.|||.   .:|.|.:|.:|.|:..:....|...:. ...::....:.|
Mouse  1041 IMLSFMTAQAPTLLLYLNFSSQ---NFLAILLSWNGSLQIHYQLSKEESHVFTINTENLANRRVH 1102

  Fly  1090 DMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK-NESM----------TDG 1143
            .:...|  .|..:.:::|. :...|.|    |.:::|...:.:.:|| .|::          |.|
Mouse  1103 QVKMSR--DGPELSIQMDQ-QLFSYTF----SLESEFQRARSLVLGKVTETLGLDPEVARANTLG 1160

  Fly  1144 FVGCVSRVQFDDIYPLK--LMFQQNPPKNVKSLGTQLTEDFC--GVEPVTHPPIEIETRPPPLVD 1204
            ||||:|.||::.|.|||  |......|..|:   ..|||..|  .|:...:....:.:...|..:
Mouse  1161 FVGCLSSVQYNHITPLKAALRHASISPVTVQ---RTLTESSCVSMVDSDANAVTTVYSSTDPFGE 1222

  Fly  1205 EEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIG---RYLHRHKGDYLTHEDQGADGADDPD-- 1264
            .::.....|.|.|. ||.:..|:.::..:.|.:||   .:.::||..:...:.:..:..::.|
Mouse  1223 RDEREPLTNAVPSD-LAVIGGIIAVVTFISFSVIGIMTHFFYQHKRSHYASQMKEKEYPENVDSS 1286

  Fly  1265 ---DAVLHSTT 1272
               |..|.:||
Mouse  1287 SRNDIDLQNTT 1297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	57..184	CDD:238014	43/133 (32%)
		LamG	192..340	CDD:238058	48/154 (31%)
		LamG	376..514	CDD:238058	54/153 (35%)
		EGF	546..575	CDD:394967	14/28 (50%)
		LamG	819..943	CDD:214598	44/125 (35%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:460494	34/151 (23%)
		4.1m	1239..1255	CDD:128590	3/18 (17%)
Cntnap5c	XP_006524804.1	FA58C	39..173	CDD:238014	43/137 (31%)
		Laminin_G_2	209..338	CDD:460494	44/128 (34%)
		Laminin_G_2	396..522	CDD:460494	43/127 (34%)
		EGF	551..582	CDD:394967	15/30 (50%)
		LamG	793..937	CDD:238058	47/145 (32%)
		EGF_CA	961..996	CDD:238011	16/34 (47%)
		Laminin_G_2	1045..1173	CDD:460494	31/137 (23%)