DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap5b

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_009294485.1	Gene:	cntnap5b / 571891	ZFINID:	ZDB-GENE-070705-209	Length:	1306	Species:	Danio rerio

Alignment Length:	1331	Identity:	405/1331 - (30%)
Similarity:	629/1331 - (47%)	Gaps:	166/1331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AFSSLQFGLLCLL---LLVNNGIKSVQADAFTDYFSDYDCNQPLME----RAVLTATSSLTERGP 68
            |.|.....|.|.|   |..||                |.||.||:.    .:..:::||...:.|
Zfish     9 ALSLHALALFCALRTTLAANN----------------YHCNGPLVSALPPTSFQSSSSSSDSQSP 57

  Fly    69 DKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWR 130
            ..|:||   |...|.|.......:|.:||.:...|..:||.||..:.::||.|::.|||.|..|:
Zfish    58 YFAKLNRRDGGGGWAPERTDRLRWLQVDLQERVEVTAVATQGRFGSPDWVTSYMLLYSDTGRAWK 122

  Fly   131 SYVNPTSEPQM--FKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDR--ISMRVELYGCDYISEN 191
            .:   ..|..:  |.||::.:.:.::.....|..:::|..|..|...  :.:|||:|||.|.|:.
Zfish   123 QF---RQEDNIGTFPGNTNSDGVVHHKLSHSIRTRFLRFLPMDWSPGGWMGLRVEVYGCAYKSDV 184

  Fly   192 LYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLG 256
            ..|||...:.|...::..::.|:.|..|||:..|:||:::..|.:|||..|:|...::.|:::|.
Zfish   185 ADFNGRSSLLYRFNQKSTSTVKDVISLRFKSQRADGVLVHGEGQRGDYITLELHKGRLALHINLD 249

  Fly   257 ------SRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLG 315
                  |....|:.:|.||||..||.|:|.|..:.|.|:|||:....|..|....|.::.||..|
Zfish   250 DAKTHPSSGHVSVFLGGLLDDQHWHSVLIERFNKQINFTVDRLTKHVRTGGLDDSLEVDYELSFG 314

  Fly   316 GVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTF 379
            |:| ..:.|..:::||.||:||:|:|..|.|    |..:..:..:::..|..::|..|.:...||
Zfish   315 GIPLPGKPGTFLRKNFHGCMENLYYNGVNII----DLAKRRKPQIYSVGNVSFSCSEPVLISSTF 375

  Fly   380 -TTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGY------LKVFLEFGKVKIDLK 437
             ::.|||:.|.....::.|:||..|||:...|::|     |.|.      |.:.|..|::::
Zfish   376 LSSSSSFLALPLDSAAETLSVSLQFRTWNREGMLL-----SVGLGKDSEKLLLLLVHGQLRL--- 432

  Fly   438 VKDKARIILDNYD----DQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGG 498
              ...|..|.:.|    ...:||:||:..|||...::.|.:|..|.:|.:..:||...:..:.||
Zfish   433 --SHHRSALQSSDIVIGQALSDGQWHTLSISIAGYQVSLAVDDEPPSTMQMKEVALPGKSLLIGG 495

  Fly   499 -----------KDKNGFVGCMRLISVDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPN 549
                       .....:.||||.:.::.   |:.|.|..:.|..    ..:..|.|.:.|||.||
Zfish   496 CPSVLSNQGCRNPTMAYQGCMRSVVINNKPINFYLVQQGLLGNY----SKLQFDICGIRDRCLPN 556

  Fly   550 PCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVN------LNLDVDG 608
            .|:|.|:|.|:...|||||..|||.||.||.|....||.|        .|:.      .::|.||
Zfish   557 YCEHDGVCSQSWSTFFCDCSGTGYTGATCHNSIFEPSCEA--------HRLTGSASGFFSIDPDG 613

  Fly   609 SGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDG--FQEPGSFEQSIMYDANQLQIEALLNRSH 671
            ||||:...|.|.. :|.:|.|.::|:......|.|  .|:|  ...:..|..:..|:..|:.||.
Zfish   614 SGPLKSTVVYCNI-TDDKVWTVVNHNSTAMVRVQGSSLQQP--HVMTFNYSTSLEQLRTLVGRSE 675

  Fly   672 SCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTK 736
            .|.|.:.|.||.|||||:    .:..|.|||:.|..:...||.|.|||.::|.|.:...|.|...
Zfish   676 HCQQEVVYLCRKSRLFNT----WDGTPLSWWLDRAGERRTYWGGFLPGVQQCACSLDENCIDMNH 736

  Fly   737 WCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFR 801
            :||||::...|..|.|.:..||:|||..:..|||.....|.:  |.:|.|.|.||....|..:|.
Zfish   737 FCNCDADRSSWENDTGILSYKEHLPVTEILVGDTNRSGSEAI--YRIGSLHCFGDRFLWNAASFY 799

  Fly   802 IADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGV 866
            ...:.::.|......|.||.|.|:||..:.|.....|..|:|:|.|:|.:.:.|.:..|:||:.:
Zfish   800 QESSYLHFPTLQAELSVDISLYFKTTAPSGVFLENLGTKDFIRLELSGPSVVTFTFDVGNGPVVL 864

  Fly   867 NVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRA-LHLTSDLVIGATTEYRDG 930
            .|.:...|||..||.|..|||.:||.|.|| .:.....|.|..... |.|.|.|.||.|...:.|
Zfish   865 TVKSHVPLNDKQWHYVRSERNVREASLQVD-QLPLRFLEAPSEGHTHLQLNSQLFIGGTASRQRG 928

  Fly   931 YVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAF 993
            ::||||:|.:||..:||:|.:|. ..|:|:||.|.|.|  :.|.|.|.|||:..||.|||..||:
Zfish   929 FLGCIRSLNINGMTLDLEERAKM-TPGVSSGCPGHCSSQNSLCHNRGKCIEKSSGYVCDCTHSAY 992

  Fly   994 KGPICADEIGVNLRSSSIIRYEFEGSF----------------RSTIAENIRVGFTTTIPKGFLL 1042
            .||.|..|:.|:..|.|.:.|.|:..|                .|...|:|...|.||.....||
Zfish   993 GGPNCKKEVSVSFESGSSVTYTFQEPFSVMRNHSRQSSAIFAQSSNSRESIAFSFLTTQTPAMLL 1057

  Fly  1043 GFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGL--GQYHDMHFMRKNGGSTVVLK 1105
            ..:: ...:|:.|.::::|.|:..:....|:...||......|  |:.|.:...|:  |..:.::
Zfish  1058 TVNT-YHQQYMAIILAHNGSLQIWYRLNREKDPDIFMPTSLNLANGELHRVQIHRE--GRDMYVQ 1119

  Fly  1106 VDNYEPVEYNFDIKASADAQFNNIQYMYIGK-------NESM----TDGFVGCVSRVQFDDIYPL 1159
            :|....::|:.    |.|.:...|:.:.:||       :|.:    :.||:||:|.|||:.:.||
Zfish  1120 IDKDTNLKYSL----STDKELITIRSLTLGKVTGRAGVDEEVLQAGSRGFIGCLSSVQFNHLAPL 1180

  Fly  1160 KLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLVDE-------EKLRKAYNEVDS 1217
            |..........|..|| .|.|..||       .:..::....|.|.       :||..|.|  ||
Zfish  1181 KAAILNRGSSLVNVLG-NLVESNCG-------ELADKSSSRSLSDSTDTGSRGKKLLNAQN--DS 1235

  Fly  1218 VLLACLLVILFLLLILMFFLIGRYLHRHKGD 1248
            .::..|:..:.|:.:....::.|:|:||:.|
Zfish  1236 AVIGGLIAAVVLITLCAVAVMTRFLYRHRHD 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	41/149 (28%)
		FA58C	57..184	CDD:238014	36/133 (27%)
		LamG	192..340	CDD:238058	53/154 (34%)
		LamG	376..514	CDD:238058	41/159 (26%)
		EGF	546..575	CDD:278437	16/28 (57%)
		Laminin_G_2	824..943	CDD:280389	45/119 (38%)
		EGF_CA	966..998	CDD:238011	17/33 (52%)
		Laminin_G_2	1032..1156	CDD:280389	33/136 (24%)
		4.1m	1239..1255	CDD:128590	5/10 (50%)
cntnap5b	XP_009294485.1	FA58C	57..178	CDD:214572	35/123 (28%)
		FA58C	57..177	CDD:238014	34/122 (28%)
		Laminin_G_2	213..342	CDD:280389	47/128 (37%)
		Laminin_G_2	400..524	CDD:280389	32/133 (24%)
		EGF	553..584	CDD:278437	17/30 (57%)
		LamG	798..939	CDD:238058	50/141 (35%)
		DUF3844	963..>1005	CDD:289707	20/41 (49%)
		Laminin_G_2	1047..1176	CDD:280389	33/135 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2641
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I703
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm24366
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.840