DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and nrxn3b

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_001073516.1 Gene:nrxn3b / 570698 ZFINID:ZDB-GENE-070206-10 Length:1403 Species:Danio rerio


Alignment Length:1408 Identity:311/1408 - (22%)
Similarity:532/1408 - (37%) Gaps:383/1408 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KSVQADAFTDYFSD--YDCNQPLM--ERAVLTATSSLTERGPDKARLNGNAAWTP------VENT 85
            |:..:||...||.|  | |:..|:  |.|.|            |.|.:.:.|.|.      |.::
Zfish    52 KTAISDALVLYFDDGGY-CDFLLLSIEDAKL------------KLRFSVDCAETTITSDKMVNDS 103

  Fly    86 YNHFLTLDLGDPRMVRKIATMGRMHTDE---------FVTE-YIVQYSDDGEFWRSYVNPTSEPQ 140
            :.||.|:...:.|.|  :|..|....||         .|:: |:.....|.......:....|..
Zfish   104 HWHFATISRHNLRTV--LALDGDSKVDEVRPQRQFMKIVSDLYLGGVPQDIRTSALTLPAAKEMP 166

  Fly   141 MFKG-NSD---GNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYG----------------- 184
            .||| .:|   ||.:                 |||...: .:|:|:.|                 
Zfish   167 PFKGIITDLGYGNKV-----------------PTRLGSQ-KVRLEMEGFCTENPCENGGSCSMAD 213

  Fly   185 ----CD---------YISENL---------------------YFNGTGLVRYDLRREPITSTKES 215
                ||         |.:|.:                     .|.|:....|||.:.||.|:.:.
Zfish   214 GEAYCDCSKTGYTGRYCNEAVNKTPGFAHMVKSPQAREENVATFRGSEYFCYDLSQNPIQSSSDE 278

  Fly   216 IRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSL--SVGSLLDDNVWHDVV 278
            |...|||...||::::: |...||..|.|||..:.|.::|||....::  .|....:||.|||:.
Zfish   279 ITLSFKTWQRNGLILHT-GKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDIK 342

  Fly   279 ISRNQRD---------------IIFSVDRVI-VRGRIQGEFTRLNLNRELYLGGVPNVQE--GLI 325
            ::||.|.               :..|||.:: ..|..|.::|.|..:...|:||.|:..:  |..
Zfish   343 VTRNLRQHSGIGHAMVNKLHCLVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSP 407

  Fly   326 VQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPS-PPIYPVTFTTRSSFVRLK 389
            |..||.|||:.:.:.:.:....:.....:.:..:..:.:.::.|.: |.:.|::|.|..||:.|.
Zfish   408 VSNNFMGCLKEVVYKNNDIRLELSRLARIADPKMKLQGDIVFKCENVPTLDPISFETAESFLGLP 472

  Fly   390 GYENSQRLNVSFYFRTYEETGVMLHH------------------DFYS----GGYLKVFLEFGKV 432
            .:...:..::||.|||.|..|::|..                  ||::    .|:|.:.|:.|..
Zfish   473 KWNTKRVGSISFDFRTSEPNGLILFTQGKPQDKKDSRSQRSNKVDFFAVELLDGHLYLLLDMGSG 537

  Fly   433 KIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQR--PMTTTKSMQVA-TGAQYY 494
            .|.:|..          .::.|||.||...|..:....|::::.|  |.|.:...::. .....|
Zfish   538 TIKVKAT----------QNKVNDGVWHHVDIQRDGRSGIISVNSRRTPFTASGENEILDLEGNLY 592

  Fly   495 IAGGKDKN----------------GFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQMI 543
            :.|..|..                |:|||:|.:.:||..|..:...:.:.|    ..:..:|..:
Zfish   593 LGGLPDNRADLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIRQIAEAQNV----GGIKSSCSKV 653

  Fly   544 --DRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSC-------LALKNVQHVQ-- 597
              .:|:.|.|::.|:|.:....|.|||..|||....|....:.||.       :.:..:.|.:  
Zfish   654 TAKQCDSNSCKNNGICKEGWNRFICDCTGTGYWDRTCEREASILSYDGSMYMKVVMPTIIHTEAE 718

  Fly   598 --------QRV--------------NLNLDVD----------GSGPLEPFPVTCEFYSDGRVITT 630
                    ||.              .|.|::|          |.||.       ..|:..:|...
Zfish   719 DVSLRFMSQRAFGLLMAATSRESADTLRLELDSGRVKLIVNLGKGPE-------TLYAGQKVNDN 776

  Fly   631 LSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYS-----CRSSRLFNSP 690
            ..||...|......:        :|.|.:  ..|..:|..|:   ||.:|     ..:.|.|.|.
Zfish   777 DWHSVRVTRRGKNIK--------LMVDDD--VAEGQMNGDHT---RLEFSNVETGILTERRFAST 828

  Fly   691 SEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWME--DGGD 753
            :.: ||                 .|.|.|.:                    .|.|.:::  ..||
Zfish   829 APS-NF-----------------IGHLQGLK--------------------FNGLLYIDMCKNGD 855

  Fly   754 IREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSG 818
            |   |:..:.| :||                 :|    .:.::.|||:...:.:.|.......:.
Zfish   856 I---EFCELNA-RFG-----------------MR----SIVADPVTFKTKGSYLGLATLQAYSTM 895

  Fly   819 DIYLEFRTTQ-ENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTV 882
            .::.:|:||. :..::|::....|:|.:.|..| .:.:.:..|:||..:...:...||||.||.|
Zfish   896 HLFFQFKTTSGDGFILFNSGDGNDFIAVELVKG-YIHYVFNLGNGPSLLKGNSDSPLNDNQWHNV 959

  Fly   883 SVERNRKEAR-LVVDGSIKAEVREPPGPVRALHLTSDLVIGA-----------TTEYRDGYVGCI 935
            .:.|:..... |.||..   .|.:.....:.|.|..||.:..           ....|:|:.||:
Zfish   960 VITRDASNTHTLKVDAK---SVSQVVNGAKNLDLKGDLFVAGLGPNMYQNLPKLVVSREGFQGCL 1021

  Fly   936 RALLLNGKMVDLKEYSKRGLYGISTGCVG---RCESNPCLNNGTCIERYDGYSCDCRWSAFKGPI 997
            .::.|||::.||...:......|..||.|   .|:.:.|.|.|.||::::.::|||..:::.|..
Zfish  1022 ASMDLNGRLPDLINDALFRSGQIERGCEGPSTTCQEDSCANMGVCIQQWENFTCDCSMTSYSGTQ 1086

  Fly   998 CADEIGVNL--RSSSIIRYEFEGSFR-STIAENIRVGFTTTIPKGFLLGF-SSNLTGEYLTIQIS 1058
            |.|.....:  :...:|.|.:..:.| ||..:.:.|||:|||..|.|:.. |:...|:|:.:.| 
Zfish  1087 CNDPGATYIFGKGGGLIMYTWPNNERPSTRTDRLAVGFSTTIKDGILVRIDSAPRLGDYIMLHI- 1150

  Fly  1059 NSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF-----DI 1118
            ..|.:...|:.|.....:.........|:||.:.|.|..|.:|  |:|||: |:..:|     ||
Zfish  1151 EEGKVCVTFNIGTVDISVKEMTTEVNDGKYHVVRFTRNGGNAT--LQVDNW-PINEHFPSGNSDI 1212

  Fly  1119 KA---------------------SADAQ---FNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPL 1159
            :.                     ..|.|   ||....:.||.|:.... :.|.:|.:.::.:..|
Zfish  1213 ERFQMANKKIPFKYTRPVEDWLHEKDRQLTIFNTQATISIGGNDRKRP-YQGQLSGLYYNGLKVL 1276

  Fly  1160 KLMFQQNPPKNVKSLGT-QLTEDFCGVEPVTHPPIEIETRPPP 1201
            .:..:.:  .|:|..|: :|..|.    |.:..|....|..||
Zfish  1277 NMAAEGH--TNIKINGSVRLVGDV----PTSRSPSRTTTSMPP 1313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 35/181 (19%)
FA58C 57..184 CDD:238014 30/146 (21%)
LamG 192..340 CDD:238058 52/188 (28%)
LamG 376..514 CDD:238058 40/178 (22%)
EGF 546..575 CDD:278437 12/28 (43%)
Laminin_G_2 824..943 CDD:280389 33/131 (25%)
EGF_CA 966..998 CDD:238011 10/31 (32%)
Laminin_G_2 1032..1156 CDD:280389 37/153 (24%)
4.1m 1239..1255 CDD:128590
nrxn3bNP_001073516.1 LamG 23..175 CDD:238058 33/137 (24%)
EGF 198..229 CDD:278437 2/30 (7%)
LamG 278..424 CDD:214598 44/146 (30%)
LamG 481..630 CDD:214598 35/158 (22%)
EGF_CA 658..691 CDD:238011 12/32 (38%)
LamG 719..844 CDD:214598 29/182 (16%)
Laminin_G_2 901..1029 CDD:280389 33/131 (25%)
LamG 1093..>1212 CDD:238058 33/122 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1324..1348
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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