DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap5a

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_009302955.1	Gene:	cntnap5a / 569185	ZFINID:	ZDB-GENE-081105-126	Length:	1306	Species:	Danio rerio

Alignment Length:	1332	Identity:	400/1332 - (30%)
Similarity:	645/1332 - (48%)	Gaps:	152/1332 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPPRSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLT- 64
            |:.|:|.   ||:      :.|.||      ||.:.|...  |.|.|:..|  .::|.|:|..:
Zfish     1 MQLPKSR---AFA------VSLTLL------SVLSSAMCG--SQYSCDGSL--SSLLPASSFQSS 46

  Fly    65 -----ERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQ 121
                 .|....|:||   |...|:|.....:.:|.:||.|...|..:||.||..:.::|:.|::.
Zfish    47 SHFSDSRAAYFAKLNKREGGGGWSPEWMDRSPWLQVDLQDRMEVTAVATQGRHSSTDWVSAYMLL 111

  Fly   122 YSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRW--HDRISMRVELYG 184
            |||.|..|:.|:...|..::. ||.:..|:.::.....|..:::|..|..|  ..|:.:||.:||
Zfish   112 YSDTGRVWKQYMLEDSVGRIV-GNVNTESVVHHKLSHSIRTRFLRFVPLEWSPSGRVGLRVAVYG 175

  Fly   185 CDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKM 249
            |.|.|....|:|...:.|...::.:::.|:.|..|||:..|.||:::..|.:|||..|:|...::
Zfish   176 CAYRSYVADFDGRSSLLYRFNQKSMSTVKDVISLRFKSRQAEGVLLHGEGQRGDYITLELHRGRL 240

  Fly   250 VLNLDL-GSRVMTS-----LSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNL 308
            .|:|:| .|||.:|     :::||||||..||.|:|.|..:.:.|::||.....|.:|:...|.:
Zfish   241 ALHLNLDDSRVRSSSARMVVTLGSLLDDLHWHSVLIERFNKQVNFTLDRHTQHFRTKGDGDSLEV 305

  Fly   309 NRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSP 372
            :.||..||:| ..:.|..:::||.||:||:|:|..|.|    |..:..:..:::..|..::|..|
Zfish   306 DYELSFGGIPLPGKPGTFIRRNFHGCMENLYYNGVNII----DLAKRRKPQIYSVGNVTFSCSEP 366

  Fly   373 PIYPVTF-TTRSSFVR-------LKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGG---YLKVF 426
            .:...|| ::.|||:.       |:|      |:|...|||:...|::|.....|..   ||.:.
Zfish   367 QLVATTFQSSSSSFLSLPAPAPVLEG------LSVRLQFRTWNPDGLLLSSPLISAQDSCYLILK 425

  Fly   427 LEFGKVKID-----LKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTT--TKS 484
            :..|::.:.     ||:.:.:.      ..:.|||.|||..:|....::.:.:|..|.::  .|:
Zfish   426 ISSGRLHLTHQTSALKMSEVSA------GQRVNDGLWHSVSLSARGLQMTMTLDNEPASSIHLKN 484

  Fly   485 MQVATGAQYYIAGG-----KDKN------GFVGCMRLISVDGNYKLPQDWVKGEEVCCG--DDVV 536
            ...|...||:  ||     .|.:      .|.||:|||.::..   |.|.:..::...|  :.:.
Zfish   485 YLEAKDKQYF--GGCPVSQNDSSCLNPTMAFQGCVRLILINNQ---PVDLLSVQQGHLGSYNQLQ 544

  Fly   537 VDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVN 601
            .|.|.:.|||..|.|:|...|.|....|.|||..|||:||.||.|....||      :|.:...:
Zfish   545 FDLCGIRDRCLYNFCEHGSRCSQTWSSFSCDCSGTGYSGATCHNSVYEASC------EHYRLAGS 603

  Fly   602 ----LNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDG--FQEPGSFEQSIMYDANQ 660
                .::|.||||||:|..|.|.. :..:|.|.:.|:..:...|.|  .|:|  ..:...|.::.
Zfish   604 SSGYFSIDPDGSGPLDPIQVYCNI-TGNKVWTVVRHNSSNPVRVQGSSLQKP--HVEWFNYSSSS 665

  Fly   661 LQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCEC 725
            .|::|||:.|..|.||:||.||.||||| |.:.   .|.|||:.|..:...||.|..||.::|.|
Zfish   666 DQLKALLSLSEHCEQRISYHCRKSRLFN-PWDG---TPLSWWVDRRGEKRTYWGGFQPGVQQCSC 726

  Fly   726 GILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEG 790
            |:...|.|...:||||::.:.|..|.|.:..||:||||.:..|||.....|.|  |.:|||:|.|
Zfish   727 GLEESCADMNYFCNCDADRVSWENDTGVLSYKEHLPVREIVIGDTYRLGSEAM--YVVGPLQCSG 789

  Fly   791 DDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQF 855
            |....|.|:|..|.:.:.........|.|:...|:|...:.|.....|..|:|::.|:....:.|
Zfish   790 DKSLWNAVSFYQAASYLQFASLQAELSLDVSFFFKTASPSGVFLENIGLHDFIRVELSSPTAVTF 854

  Fly   856 QYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLV 920
            .:..|.||:.:.|.:...|||..||.|..|||.|||.|.||......:..||.....|.|.:.|.
Zfish   855 SFNVGDGPVVLTVKSPVPLNDRQWHWVRAERNVKEACLQVDQLPLRIIETPPDGHLRLQLGNQLF 919

  Fly   921 IGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNP--CLNNGTCIERYDG 983
            :|.|...:.|::|||||..:||...||:|.:| ...|:|:||.|.|.|:.  |.|.|.|:|:..|
Zfish   920 VGGTATRQRGFLGCIRAFNMNGVNFDLEERAK-VTPGVSSGCAGHCSSSAGLCHNRGKCVEKSSG 983

  Fly   984 YSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFR----------------STIAENIRVGF 1032
            |.|||..||:.||.|.:|:.::....:.:.|.|:..|.                |...:|:.:.|
Zfish   984 YMCDCTNSAYGGPSCTEEVSMSFERGASVTYIFQEPFSVIQNRSAAVLSVPSQYSKSRDNMALSF 1048

  Fly  1033 TTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGL--GQYHDMHFMR 1095
            .||.....||..:: |:.:|:.:.::.:|.|:..:....|::..:|......|  |:.|.:|..|
Zfish  1049 QTTQSPAMLLTVNT-LSQQYVAVILARNGSLQIWYQLHKEKRPDVFSPILSSLADGRLHRVHIQR 1112

  Fly  1096 KNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK---NESMTD--------GFVGCVS 1149
            :  |..|.::||. |..:|..    |.||:||:::.:.:||   .:.|.|        |||||.|
Zfish  1113 E--GKDVFVQVDR-ENKKYTL----SFDAKFNSMKSLTLGKVTGRDLMDDEVAHAGSKGFVGCFS 1170

  Fly  1150 RVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLVDEEKLRKAYNE 1214
            .|||:.:.|||... .|...::.|:...|.|..||........:........:..:.|..:..::
Zfish  1171 SVQFNHVAPLKAAL-LNRGSSLVSIRGNLLESNCGALADLSTSVSRLDHGEEVGKDNKHHEDASQ 1234

  Fly  1215 VDSVLLACLLVILFLLLILMFFLIGRYLHRHK 1246
            .||.::..::.......:.:..::.|:|::|:
Zfish  1235 PDSAVIGGVVTAAVFSTVCVLAVMLRFLYQHR 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	41/149 (28%)
		FA58C	57..184	CDD:238014	38/137 (28%)
		LamG	192..340	CDD:238058	54/154 (35%)
		LamG	376..514	CDD:238058	42/166 (25%)
		EGF	546..575	CDD:278437	13/28 (46%)
		Laminin_G_2	824..943	CDD:280389	41/118 (35%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	40/136 (29%)
		4.1m	1239..1255	CDD:128590	3/8 (38%)
cntnap5a	XP_009302955.1	FA58C	54..176	CDD:214572	35/122 (29%)
		FA58C	54..175	CDD:238014	34/121 (28%)
		LamG	182..338	CDD:238058	54/155 (35%)
		Laminin_G_2	399..525	CDD:280389	33/133 (25%)
		EGF_CA	552..586	CDD:238011	17/33 (52%)
		COLFI	605..>689	CDD:295304	30/86 (35%)
		LamG	804..940	CDD:238058	42/135 (31%)
		EGF_2	964..998	CDD:285248	16/33 (48%)
		Laminin_G_2	1048..1177	CDD:280389	40/136 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2641
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I703
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm24366
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.070