DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-IV and nrxn1a

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_009304916.1 Gene:nrxn1a / 565531 ZFINID:ZDB-GENE-070206-1 Length:1497 Species:Danio rerio


Alignment Length:1574 Identity:349/1574 - (22%)
Similarity:577/1574 - (36%) Gaps:469/1574 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TKAAFSSLQFGLL--------C--LLLLVNNGIKSVQADAF----TDYFSDYDCNQPLMERAVLT 58
            ||:|     .|||        |  |.||::||..|::...|    ...|||...|........|.
Zfish    57 TKSA-----HGLLVYFDDEGFCDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLR 116

  Fly    59 ATSSLTERGPDKARLNGNAAWTPVEN------TYNH-FLTLDLGDPRMVRKIATMGRMHTDEFVT 116
            .....|....|:     ...|..|::      .::| ||.   |.|..:|.:|.  |:.:.....
Zfish   117 RNFKNTTLVVDE-----EIKWVEVKSKRRDMTVFSHLFLG---GIPPELRSVAL--RLTSSAIKD 171

  Fly   117 EYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISM--- 178
            |  |.|.  |......|| .|||.:.  .|||  ::.::.|.               |.|.:   
Zfish   172 E--VPYK--GWITNLRVN-GSEPVLI--GSDG--VNSDICEA---------------DHICLNGG 212

  Fly   179 --------------RVELYGCDYISENLY------------------------FNGTGLVRYDLR 205
                          .....|.|...|..|                        |.|:....|||.
Zfish   213 VCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLS 277

  Fly   206 REPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSL--SVGSL 268
            ..||.|:.:.|...|||...||:|::: |...||..|.||:..:.|.::|||....:|  .|...
Zfish   278 PNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 341

  Fly   269 LDDNVWHDVVISRNQRD--------IIFSVDRVI-VRGRIQGEFTRLNLNRELYLGGVPNVQE-- 322
            .:||.||||.::||.|.        :..|||.:: ..|..|.::|.|..:...|:||.|:..:  
Zfish   342 FNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLP 406

  Fly   323 GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPS-PPIYPVTFTTRSSFV 386
            |..|..||.|||:.:.:.:.:....:....:||:..:.......:.|.: ..:.||||.|..||:
Zfish   407 GSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFI 471

  Fly   387 RLKGYENSQRLNVSFYFRTYEETGVMLHH--------------------DFYS----GGYLKVFL 427
            .|..:...:..::||.|||.|..|::|..                    ||::    .|:|.:.|
Zfish   472 TLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLL 536

  Fly   428 EFGKVKIDLKVKDKARIILDNYDDQFNDGKWH---------SFVISIEKNRL---------ILNI 474
            :.|......:..:|          :.|||:|:         |..||:...|.         ||::
Zfish   537 DMGSGTTKTRAVNK----------KVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDL 591

  Fly   475 DQRPMTTTKSMQVATGAQYYIAGGKDKN----------------GFVGCMRLISVDGNYKLPQDW 523
            |.:               .|:.|..:..                |:|||:|.:.:||..|     
Zfish   592 DDK---------------LYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSK----- 636

  Fly   524 VKGEEVCCGDDV--VVDACQMI-----------DRCNPNPCQHKGLCHQNSREFFCDCGHTGYAG 575
                      |:  :.:|.:.:           .:|..|||.:.|.|.:....:.|||..|||.|
Zfish   637 ----------DIRRIAEAQRAVGVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLG 691

  Fly   576 AVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVITTLSHSQEH 637
            ..|......||....|.:: :|..|.::.:.:        .|:..|.|.   |.::.|.|.:...
Zfish   692 RSCERDATILSYDGSKFMK-IQLPVVMHTEAE--------DVSLRFRSQRAYGVLMATTSQNSAD 747

  Fly   638 TTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWW 702
            |..::             .|..::::...|:    |   :..:|.:|:...:.....|.....|.
Zfish   748 TLRLE-------------LDGGRVRLTVNLD----C---IRINCTTSKGPETIFSGQNLNDNEWH 792

  Fly   703 ---ISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWME-DGGDIREKEYLPVR 763
               :.|..:.:......|..|   |..|.|           |...||:.. :.|.:.||.|:|..
Zfish   793 TVRVVRRGKSLKLMVDDLQPS---EGQITG-----------DHTQLEFHNVETGIVTEKRYMPAV 843

  Fly   764 AVKFGDTGTPLDEKMGRYTLGPLR------------CEGDD--------------LFSNVVTFRI 802
            ...|               :|.|:            |:..|              :.::.|||:.
Zfish   844 PSNF---------------IGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVADPVTFKS 893

  Fly   803 ADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGP-TDYIKLSLNGGNKLQFQYQAGSGPLGV 866
            ..:.:.||.....:|..::.:|:||..:.:|.:..|. .|:|.:.|..| .|.:....|:|...:
Zfish   894 RSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKG-YLHYVSDLGNGAHLI 957

  Fly   867 NVGTSYHLNDNNWHTVSVERNRKEARLV-VDGSIKAEVREPPGPVRALHLTSDLVIGATTE--YR 928
            ...::..||||:||.|.:.|:......| :|..|..:...   ..:.|.|..||.:|...:  |:
Zfish   958 KGNSNTPLNDNHWHNVMISRDTNNLHTVKIDTKITTQTTM---GAKNLDLKGDLYVGGVAKDMYK 1019

  Fly   929 D---------GYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGR----------------CES 968
            |         |:.||:.::.|||::.||:..:......:..||.|.                |:.
Zfish  1020 DLPKLVHSKEGFQGCLASVDLNGRLPDLQSDALSTAGQVERGCEGEENVALLKADLQGPSTTCQE 1084

  Fly   969 NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNL---RSSSIIRYEFEGSFR-STIAENIR 1029
            :.|.|.|.|:::::|:||||..:::.||:|.|. |...   |...:|.|.:..:.| ||.|:.:.
Zfish  1085 DSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDP-GTTYIFGRDGGLIVYTWPPNDRPSTRADRLA 1148

  Fly  1030 VGFTTTIPKGFLLGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHF 1093
            |||:|......|:.. ||:..|:||.:||.. |:::.||:.|.:...|....|....|:||.:.|
Zfish  1149 VGFSTQQKDAVLVRVDSSSGLGDYLQLQIER-GNIKVVFNVGTDDINIEETSKFVNDGKYHIVRF 1212

  Fly  1094 MRKNGGSTVVLKVDNYEPVEY----NFDIKASADAQ------------------------FNNIQ 1130
            .|..|.:|  |:||:...:|.    |.|.:..|.|:                        ||:..
Zfish  1213 TRSGGNAT--LQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQT 1275

  Fly  1131 YMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLG-------------------- 1175
            .:.||..|..:..|.|.:|.:.::.:..|.:..:.:|  ||:..|                    
Zfish  1276 TIKIGGWEKGSRPFQGQLSGLYYNGLKVLNMAAEGDP--NVRVEGSARLVGDMPSSSITPQSSVS 1338

  Fly  1176 ------------TQLT------------------------------EDFCGVEP----VTHPPI- 1193
                        |.:|                              ||....:|    :.|||: 
Zfish  1339 AAGNRSETSPSITDITTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDPCDPSSGGLAHPPLP 1403

  Fly  1194 EIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQG-- 1256
            |.:..|.|.|..|. ......|..::.|..|.||.||     :.:.:|.:|.:|.|  |.|:.  
Zfish  1404 EAKGYPSPEVIRES-SSTTGMVVGIVAAAALCILILL-----YAMYKYRNRDEGSY--HVDESRN 1460

  Fly  1257 --ADGADDPDDAVL 1268
              ::.|..|:.|.:
Zfish  1461 YISNSATQPNGAAV 1474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 29/162 (18%)
FA58C 57..184 CDD:238014 28/150 (19%)
LamG 192..340 CDD:238058 55/184 (30%)
LamG 376..514 CDD:238058 41/195 (21%)
EGF 546..575 CDD:278437 12/28 (43%)
Laminin_G_2 824..943 CDD:280389 35/131 (27%)
EGF_CA 966..998 CDD:238011 12/31 (39%)
Laminin_G_2 1032..1156 CDD:280389 39/152 (26%)
4.1m 1239..1255 CDD:128590 5/15 (33%)
nrxn1aXP_009304916.1 LamG 27..185 CDD:238058 35/146 (24%)
LamG 287..426 CDD:214598 46/139 (33%)
LamG 483..634 CDD:214598 34/175 (19%)
EGF_CA 662..695 CDD:238011 13/32 (41%)
Laminin_G_2 728..859 CDD:280389 30/179 (17%)
Laminin_G_2 915..1043 CDD:280389 35/131 (27%)
Laminin_G_2 1151..1300 CDD:280389 39/151 (26%)
Syndecan 1410..1475 CDD:279386 19/73 (26%)
4.1m 1442..1460 CDD:128590 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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