DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap3

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_005155581.1	Gene:	cntnap3 / 564195	ZFINID:	ZDB-GENE-091113-51	Length:	1300	Species:	Danio rerio

Alignment Length:	1305	Identity:	410/1305 - (31%)
Similarity:	646/1305 - (49%)	Gaps:	136/1305 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SDYDCNQPL---MERAVLTATSSL-TERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMV 100
            |...|:.||   :.::..|::|.| :..||..|:||   |...|:|:::....:|.:.|.....:
Zfish    27 SKESCDSPLVSGLPQSAFTSSSELSSSHGPGFAKLNRRDGAGGWSPLDSNKYQWLEIKLEQRTEI 91

  Fly   101 RKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWV 165
            ..:::.||..:.::||.|::.:||.|..||.|....| ...|.|||:.:|:.....:.|::||::
Zfish    92 TGVSSQGRYGSSDWVTRYLLMFSDTGHNWRPYRQEDS-IGAFSGNSNADSVVMYKLQQPVVAQYL 155

  Fly   166 RINPTRW--HDRISMRVELYGCDYISENLYFNGTGLVRYDLRREP--ITSTKESIRFRFKTAFAN 226
            ||.|..|  :.||.:|:|.|||.|.|:...|:|...:.|  |.:|  ..:.|:.:...|||..::
Zfish   156 RILPLDWNPNGRIGLRLEAYGCQYRSDVAGFDGAAHLLY--RPDPGVNPADKDMLSMNFKTMQSS 218

  Fly   227 GVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSL----SVGSLLDDNVWHDVVISRNQRDII 287
            |::::.....|....|.|...::||.|..|..:....    ||||||||..||.|.|.|.:..:.
Zfish   219 GLLLHMEAHSGHTLTLDLFKGRLVLQLRKGRALSADFHPLWSVGSLLDDQHWHHVSIERVRGLVN 283

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGG-VPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS 351
            |:||:...:.::...::|..:: |:.:|| .|:..:....::||.|||||:::|..:.|...|:.
Zfish   284 FTVDKNTQQFQLPEYWSRSEID-EISVGGSSPSGLQKSHSRRNFHGCLENVFYNGVSVIDGAKEK 347

  Fly   352 TELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHD 416
            .....|      |..:||......||||....||:.:......:.::||..|||:.:.|:::..|
Zfish   348 RVAITG------NVSFACSESIEVPVTFAGPRSFLAVPWVSGGESVSVSLEFRTWNKAGLLMTFD 406

  Fly   417 F-YSGGYLKVFLEFGKVKIDLKVKDKARIILD-NYDDQFNDGKWHSFVISIEKNRLILNIDQRPM 479
            . .:.|.|.::|...|.:  |:::...||:.| ......|||:||...::|.:.||.:.:||
Zfish   407 LQQNAGTLWLYLSEAKAR--LQIQKSGRILTDVTAGVNLNDGQWHRLELAIRRGRLAVTVDQ--- 466

  Fly   480 TTTKSMQVATGA-----QYYIAGGKDKNG---------FVGCMRLISVDGNYKLPQDWVKGEEVC 530
              |.|..|||..     .....||...:|         |.||||||..||..   .|.:|.:::.
Zfish   467 --TDSSAVATSVFAAPDSVLFLGGCPGDGSGCRNPFNVFQGCMRLIRTDGAL---VDLIKVQQML 526

  Fly   531 CGD--DVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNV 593
            .|:  |:.:|.|.::|||:||.|:|.|.|.|:...|.|:|..|||:||.||:|....||.|.|:
Zfish   527 LGNFSDLQMDVCGIVDRCSPNHCEHGGKCSQSWSTFHCNCSATGYSGATCHSSIYEASCEAYKH- 590

  Fly   594 QHVQQRVNLN----LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSI 654
                 :.|.:    :|||||||::|..:.|.......::.     |.:.|.:...:......|.:
Zfish   591 -----KGNTSGFYYIDVDGSGPIKPQLIYCNMSDKAWMVI-----QHNNTELTKLKTSSGINQHL 645

  Fly   655 M---YDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGA 716
            .   |.|:..||.|::::|..|.|.|||.||.|||.|:|..|    |||||:....:...||.||
Zfish   646 AHFNYSADAEQIRAVISQSEHCEQELSYHCRKSRLLNTPDGA----PFSWWVGGSGEAHMYWGGA 706

  Fly   717 LPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRY 781
            :|||::|.||:.|.|..|..:||||::|.:|..|.|.:..||:|||:::..||......|  ..|
Zfish   707 VPGSQQCACGLQGNCVHPEHFCNCDADSKDWSNDSGLLAHKEHLPVQSLALGDISRSGSE--AAY 769

  Fly   782 TLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLS 846
            .:|||:|.||..|.|...|....:.::.|.|....|.||...|:|:..:.|.....|..|:|::.
Zfish   770 RVGPLQCYGDGNFWNTAYFNKETSYLHFPTFHGELSADISFLFKTSSSSGVFLENLGFKDFIRIE 834

  Fly   847 LNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVR 911
            |:...::.|.:..|:|||.|.|.|...|||..||.|..|||.|||.|.||....|..:.|.....
Zfish   835 LSSPTEVVFSFDVGNGPLDVRVQTPSALNDERWHHVRAERNVKEASLCVDQHPAAVQKAPADGHI 899

  Fly   912 ALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLY--GISTGCVGRCES--NPCL 972
            .|.|.|.|.:|.|...:.|::||||:|.|||:.:||:|   |...  |:|.||.|.|.|  ..||
Zfish   900 HLQLNSQLFVGGTASRQKGFLGCIRSLKLNGRTLDLEE---RAAITPGVSAGCPGHCSSYGGLCL 961

  Fly   973 NNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFR---------STI---- 1024
            |:|:|:|:|.|::|||..|.|.|..|..|:....:..:.:.|.|:..:.         |:|
Zfish   962 NHGSCVEKYSGFTCDCSLSPFTGTFCHKELSAFFKPGTSVTYTFKEPYELNRNISAQSSSIYSDL 1026

  Fly  1025 ---AENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIF--PKKHFG 1084
               .|||.:.|.|:.....|| :.::...|||:|.::.:|||...:.....|:..:|  ..::..
Zfish  1027 TLRGENISLSFRTSQAPALLL-YVNSYYREYLSILLNRNGHLDVKYKLAHSREAEVFRASGRNLA 1090

  Fly  1085 LGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK--NESMTD----- 1142
            .||.|.:...|.  ..|:.::||.:|..|:|.    ::|.:||.|:.:.|||  :....|
Zfish  1091 NGQLHRVSVQRL--AETLSIQVDQHEKEEFNL----TSDTEFNAIKSIVIGKVLDSGEVDPEIGR 1149

  Fly  1143 ----GFVGCVSRVQFDDIYPLK--LMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPP 1201
                ||.||:|.|||:.|.|||  |::....|..|..   .|:|..||...:::|.....|.  .
Zfish  1150 LNALGFTGCLSVVQFNSISPLKAALLYPDTSPVIVTG---SLSESGCGSSLLSNPHAAETTH--S 1209

  Fly  1202 LVDE-------EKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADG 1259
            |.|.       |.:..|.|. ||.|:..::.::..:.:....:..|:|:|.|..:.:.|.:....
Zfish  1210 LTDHVGTVGTGEPIVNAING-DSALIGGVIAVVIFVSLSALAVTARFLYRRKETFQSQEPKAGKT 1273

  Fly  1260 ADDPD 1264
            .|.|:
Zfish  1274 DDSPE 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	45/147 (31%)
		FA58C	57..184	CDD:238014	41/132 (31%)
		LamG	192..340	CDD:238058	45/154 (29%)
		LamG	376..514	CDD:238058	46/153 (30%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	46/118 (39%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	39/136 (29%)
		4.1m	1239..1255	CDD:128590	5/15 (33%)
cntnap3	XP_005155581.1	FA58C	35..176	CDD:238014	42/141 (30%)
		FA58C	59..177	CDD:214572	37/118 (31%)
		Laminin_G_2	212..338	CDD:280389	40/126 (32%)
		LamG	366..511	CDD:238058	45/151 (30%)
		EGF	544..575	CDD:278437	15/30 (50%)
		FReD	583..>627	CDD:294064	14/54 (26%)
		LamG	785..929	CDD:238058	50/143 (35%)
		EGF_CA	953..987	CDD:238011	16/33 (48%)
		Laminin_G_2	1037..1167	CDD:280389	39/136 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2641
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I703
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm24366
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	LDO	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980