DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and CG6974

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	57/330 - (17%)
Similarity:	105/330 - (31%)	Gaps:	116/330 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDKARL 73
            ||....|..|:....|:.:.||:|     :.:|:::...:....|.....|.:|..:|.|
  Fly     4 KAVRYLLLAGIFAPNLVASEGIES-----YENYYNEIHIDDEQAEAKTRNALTSPLQRWP----- 58

  Fly    74 NGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSD-DG--EFWRSYVNP 135
             ||.....:...|:.            :::|.: |.....|..:..||:.: :|  ...:.||:.
  Fly    59 -GNKILYRISTDYSE------------QEVANV-RTAMSSFGEQTCVQFEEIEGAPPAGKRYVSF 109

  Fly   136 TSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISM-----------RVELYGCDY-- 187
            ...|.|.........:.:...||.:..:.:.:.....|:.:.:           |.|....||
  Fly   110 KKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDN 174

  Fly   188 -----------ISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYA 241
                       :.:...||    |.||.         ||:....|.|||
  Fly   175 IPRKYWSQFMAMDQTTTFN----VPYDY---------ESVMHYSKNAFA---------------- 210

  Fly   242 LQLKD-NKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVI--VRGRIQGEF 303
               || :|..:...:|.:                              :|:|.:  |||..:|::
  Fly   211 ---KDPSKPTIRALIGGK------------------------------AVEREMGQVRGPSEGDW 242

  Fly   304 TRLNL 308
            |::.|
  Fly   243 TKIRL 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	23/152 (15%)
		FA58C	57..184	CDD:238014	22/140 (16%)
		LamG	192..340	CDD:238058	23/120 (19%)
		LamG	376..514	CDD:238058
		EGF	546..575	CDD:278437
		Laminin_G_2	824..943	CDD:280389
		EGF_CA	966..998	CDD:238011
		Laminin_G_2	1032..1156	CDD:280389
		4.1m	1239..1255	CDD:128590
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	45/274 (16%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	43/264 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930