DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-IV and CG10280

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001246942.1	Gene:	CG10280 / 40740	FlyBaseID:	FBgn0037395	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	73/360 - (20%)
Similarity:	110/360 - (30%)	Gaps:	136/360 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 GGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLP-PFDM 814
            |.|..|.|:..|..|.     .||.::...|  ||  ..|||           |..|:.| ....
  Fly    75 GVDFFEHEFTSVAEVL-----KPLSDEYDPY--GP--DIGDD-----------DLGIDDPETMPR 119

  Fly   815 GHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNW 879
            ...|||               |..|..||.|.|            |..|:
  Fly   120 LFQGDI---------------AIDPYTYITLRL------------GVNPM--------------- 142

  Fly   880 HTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKM 944
                    |...||..:|:|..|:..     |..:.....:|.|...:..  :.|:..:..:|::
  Fly   143 --------RHPKRLWPNGTIPFEISP-----RYANQERQAIIQAVKTFNS--LTCVHFVPYDGEV 192

  Fly   945 VD--LKEYSKRGLYGISTGC---VGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICAD---E 1001
            .|  |.|....|    ..||   |||......::    ::|.|..|..|..|  :|.|..:   .
  Fly   193 DDYLLIEPPLEG----PQGCWSYVGRRGGEQVVS----LQRPDENSAHCFSS--EGRIMHELMHA 247

  Fly  1002 IGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIP---KGFLLGFSSNLTGEYLTIQISNSGHL 1063
            ||:....|...|..|           :::.:...:|   |.|.|  .|...|:|
  Fly   248 IGIYHEQSRADRDNF-----------VKIHWDNIVPRFRKNFKL--VSKKKGKY----------- 288

  Fly  1064 RCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNG 1098
              .||:.:.      ...|:|     :.:|.::.|
  Fly   289 --AFDYDYN------SVMHYG-----EFYFSKRKG 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058
		LamG	376..514	CDD:238058
		EGF	546..575	CDD:278437
		Laminin_G_2	824..943	CDD:280389	18/118 (15%)
		EGF_CA	966..998	CDD:238011	6/31 (19%)
		Laminin_G_2	1032..1156	CDD:280389	13/70 (19%)
		4.1m	1239..1255	CDD:128590
CG10280	NP_001246942.1	Astacin	147..344	CDD:279708	44/218 (20%)
CG10280	NP_001246942.1	ZnMc_astacin_like	151..342	CDD:239807	42/214 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930