DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and kon

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001260539.1	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster

Alignment Length:	1135	Identity:	223/1135 - (19%)
Similarity:	395/1135 - (34%)	Gaps:	304/1135 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 SMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYA 241
            :|:|.|:|..|:|..|             :|...||  :||.:|:|...|..:..:.| :.||..
  Fly    27 AMKVSLFGDGYVSMPL-------------QEAKMST--NIRVKFRTRQENAFLFLAAG-RTDYCL 75

  Fly   242 LQLKDNKMVLNLDLGSRVMTSLS-VGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTR 305
            |:|:...:..:..:...|:...| ....|:|..||||.:.|.:.:|...||..|:|.::.|:...
  Fly    76 LRLESGLISFSYKIERDVVQLRSPKKQKLNDLEWHDVAVQRFENNITLQVDGYIMRKQLPGDLAA 140

  Fly   306 LNLNRELYLGGVPN-VQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYAC 369
            ||::...:||||.: ..|.|.....|.||:.::::|:.|.|:..||.|.     ..|.....:.|
  Fly   141 LNIHFGTFLGGVGDFTAEFLDDVIGFRGCISDVFYNNINIIKRAKDRTS-----HTTSTGVAWTC 200

  Fly   370 PSPPIYPVTFTTRSSFVRLKGYENSQRLN------VSFYFRTYEETGVMLHHDFYSGGYLKVFLE 428
            .:.  :..:.....||:|...|....:.:      :|..|||....||:    |::|||..:.||
  Fly   201 STE--FEGSIQDSISFMRNDSYSLMMKESYAMGETLSLQFRTMASAGVI----FFNGGYDFILLE 259

  Fly   429 FGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFV------------------------------I 463
            .....:.:.......::....::..:|||||...                              |
  Fly   260 IEDQHLKVTFNKAGSLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASI 324

  Fly   464 SIEKNRLILNI--DQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKG 526
            ::||:.....:  :.|....:|.:::            ::..|.||||.|.|:   .||..:.
  Fly   325 NLEKSVFFGGVQEEMRRRLISKGLRI------------NEISFKGCMRDILVN---DLPLGFA-- 372

  Fly   527 EEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALK 591
             |:.....:.::..........|||...|:|.|:           |..|.:|:...:  .|
  Fly   373 -EMTISRSLALNCLWKYPCVEYNPCLKSGICSQH-----------GVDGFICYCDQS--YC---- 419

  Fly   592 NVQHVQQRVNLNLDVDGSGPLEPFPVTCE-----FYSDGRVI---TTLSHSQEHTTTVDGFQEPG 648
                        :..|..||.:.|..|..     :.|..:::   |...........:|..:.|.
  Fly   420 ------------IKADFQGPFKIFTETSPELELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPS 472

  Fly   649 SFEQSIMYD-ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDY 712
            ..||||::. .:|.:...||  .:|..:.:...||:..|.:..::...:        .||...::
  Fly   473 LNEQSIIFHVVHQPKYGQLL--QYSAEKAIFVPCRTFNLVDLATDKLKY--------VHNGQENF 527

  Fly   713 WAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIRE--KEYLPVRAVKFGDTGTPLD 775
                                       .|..:|: |:..||:.:  :..|...........||::
  Fly   528 ---------------------------NDHATLD-MQIFGDVHKIPENILGKHRFLLHANITPIN 564

  Fly   776 E--KMGRYTLGPLR-CEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHAT 837
            :  ::..::...|| .||.:...:|..|.|.|     |..:.|:.....|..::.||....|...
  Fly   565 DPPQLRLHSHKILRVIEGIERVLDVDLFNIDD-----PDSEPGNLIYTILPTQSPQETFGCFIVG 624

  Fly   838 GPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVG-TSYHLNDNNWHTVSVERNRKEARLVVDGSIKA 901
            |.|                 .:......|||| .||..|.....:.|.|...:    |.||...:
  Fly   625 GAT-----------------TSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQ----VSDGIETS 668

  Fly   902 EVREPPGPVRALHL-------------------TSDLVIGATTEYRDGYV------------GCI 935
            |....|..|..|.|                   |::|.||  |...|.::            |.:
  Fly   669 ETVYLPVSVHPLELRLVNNTGLIMIHKSSLPISTANLSIG--TNAVDDHIDIRYDIVKAPQHGVL 731

  Fly   936 RAL-LLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICA 999
            :.| .::|..|::..:|...|      .:|..             || .:|.|..|.
  Fly   732 QRLRQIDGSWVNVDWFSDSQL------LLGHI-------------RY-LHSSDFPWQ-------- 768

  Fly  1000 DEIGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIPKGFLLGFSSN--LTGEYLTIQISNSGH 1062
            ||.........:....|:  ||.|..   |:..|:|.|....:..|..  ||.:.|:.:.:..|
  Fly   769 DEFKFIASFGFVTTQTFD--FRITFT---RLRITSTRPSQISINGSREILLTSDVLSYETTPIG- 827

  Fly  1063 LRCVFDFGFERQ---EIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADA 1124
                   .|.|.   :|..|.::.|:  |.:       |......|:|::          ...|.
  Fly   828 -------SFARSVIYKITKPTRYGGI--YVE-------GSRKAAKKLDSF----------TQQDI 866

  Fly  1125 QFNNIQYM-YIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPV 1188
            :...|:|. :.....|.:|.....||..:.||:..:..:..:.|.:.:..||.|
  Fly   867 EKRRIRYQTHHTSYSSFSDHLEFVVSVAECDDVAGVLEINYRPPDELINKLGYQ----------- 920

  Fly  1189 THPPIEIETRPPPLVDEEKLRKAYNEVDSV 1218
            .|.|::::.....|:.:......:|..:|:
  Fly   921 NHEPLQVQEGERALITKNHFGIRFNIYESL 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	3/7 (43%)
		FA58C	57..184	CDD:238014	3/6 (50%)
		LamG	192..340	CDD:238058	40/149 (27%)
		LamG	376..514	CDD:238058	32/175 (18%)
		EGF	546..575	CDD:278437	7/28 (25%)
		Laminin_G_2	824..943	CDD:280389	30/151 (20%)
		EGF_CA	966..998	CDD:238011	5/31 (16%)
		Laminin_G_2	1032..1156	CDD:280389	25/129 (19%)
		4.1m	1239..1255	CDD:128590
kon	NP_001260539.1	LamG	30..176	CDD:238058	45/161 (28%)
		LamG	211..365	CDD:238058	32/169 (19%)
		Cadherin_3	507..664	CDD:292802	37/218 (17%)
		Cadherin_3	631..776	CDD:292802	37/178 (21%)
		Cadherin_3	747..892	CDD:292802	37/204 (18%)
		Cadherin_3	861..1005	CDD:292802	18/111 (16%)
		Cadherin_3	979..1121	CDD:292802
		Cadherin_3	1093..1242	CDD:292802
		Cadherin_3	<1264..1361	CDD:292802
		Cadherin_3	1330..1464	CDD:292802
		Cadherin_3	1436..1578	CDD:292802
		Cadherin_3	1789..1932	CDD:292802
		Cadherin_3	2009..2163	CDD:292802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910