DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cubn

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	153/784 - (19%)
Similarity:	232/784 - (29%)	Gaps:	300/784 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 SFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLIS--VDGN------ 516
            ||.:| ..:||.:|.:...|    .:.:||......:|||| :.||....|..  .|.|
  Fly    53 SFRLS-GNSRLTINEELDVM----ELLLATSGSKKRSGGKD-DDFVDARELADQLADFNRRAFGA 111

  Fly   517 ------YKLPQDWVKGEEVCCGDDVVVDACQ--------MIDR---------CNPNPCQHKGLCH 558
                  .::.|:..:|..      .::...|        .:||         |...||::.|.|:
  Fly   112 NGLSAMLRVQQNRTRGSM------ALLRRFQTRLRALENRVDRMKTDLEANSCASGPCENGGTCY 170

  Fly   559 QNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYS 623
            .....|.|.| .:.:.|..|                        .:||:.....|...:.|:
  Fly   171 NTYTGFRCQC-RSAFEGTKC------------------------EMDVNECALYEGTDLGCQ--- 207

  Fly   624 DGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFN 688
            :|      ...|.|..|.....:||                  .:..| |.||.:...:||
  Fly   208 NG------GQCQNHFGTYSCLCQPG------------------WHGMH-CTQRKADCSQSS---- 243

  Fly   689 SPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKC----HDPTKWCNCDSNSLEWME 749
                       :|.:..|                      |.|    .|....|.|:..   |..
  Fly   244 -----------AWELCGH----------------------GSCVPSADDAGYRCICEPG---WKT 272

  Fly   750 DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADAS-INLP--- 810
            :|                               |.|:..|..|..|:....:....| ||||
  Fly   273 NG-------------------------------LTPICGEDVDECSDSAAHKPCSTSCINLPGSF 306

  Fly   811 -----PFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGT 870
                 |..:..:|....:....|.|                 |||..|..:...      :|...
  Fly   307 TCAPCPAGLTGNGVSCRDLDECQTN-----------------NGGCSLSPKVDC------INTYG 348

  Fly   871 SYHLND--NNWHTVSVERNRKEARLVVDGSIKAEVRE---PPGPVRALHLTSDLVIGATTEYRDG 930
            |||..:  ..|    ....||..|...|..|.|....   |.|........|..:|..||..|
  Fly   349 SYHCGECPVGW----TGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCR-- 407

  Fly   931 YVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG----RCESNPCLNNGTCIERYDG---YSCDC 988
               |...::..|             || ..|||.    .|:.|||||.|.|:  :.|   |:|.|
  Fly   408 ---CPMGMVGTG-------------YG-PNGCVNGTTTNCKENPCLNGGICL--FAGPSNYTCLC 453

  Fly   989 RWSAFKGPICADEIGVNLRSSSIIRYEFE--GSFRSTIAENIRVGFTTTIP--KGFLLGFSSNLT 1049
            . ..|:.|||..:      .|...::..:  |..|.|.:.::.|  ...:|  :|.|.....:..
  Fly   454 P-IGFRPPICEPQ------PSPCDQHPCKNGGRCRPTTSGDLFV--CQCLPGYRGRLCETRFSSC 509

  Fly  1050 GEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMH--FMRKNGGSTVVLKVDNYEPV 1112
            ...|:.|   ||.||             :|.:  |.|..|:..  ::.:...|.||       .|
  Fly   510 NGMLSAQ---SGRLR-------------YPPE--GTGYEHNAQCAWVIRTNESLVV-------NV 549

  Fly  1113 EYN-FDIKASADAQFNNIQYMYIGKNESMTDGFVG--CVSRVQFDDIYPLKLMFQQNPPKNVKSL 1174
            .:| ||::.|.:.:|:   ::.|....|.....:|  |.:.:....              |:.|.
  Fly   550 TFNSFDVEDSTECRFD---WLQINDGRSAAAQIIGRYCGNHLPHGG--------------NIVSS 597

  Fly  1175 GTQL 1178
            |.||
  Fly   598 GNQL 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058
		LamG	376..514	CDD:238058	16/55 (29%)
		EGF	546..575	CDD:278437	8/28 (29%)
		Laminin_G_2	824..943	CDD:280389	25/123 (20%)
		EGF_CA	966..998	CDD:238011	14/34 (41%)
		Laminin_G_2	1032..1156	CDD:280389	26/130 (20%)
		4.1m	1239..1255	CDD:128590
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011	10/58 (17%)
		EGF_CA	192..233	CDD:238011	11/68 (16%)
		EGF_CA	282..322	CDD:214542	9/39 (23%)
		EGF_3	328..366	CDD:289699	12/64 (19%)
		EGF	430..457	CDD:278437	12/29 (41%)
		EGF_CA	469..503	CDD:238011	7/35 (20%)
		CUB	509..622	CDD:238001	28/135 (21%)
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930